Results 101 to 110 of about 403,028 (282)
Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration
Cells, 2020 Cardiovascular disease (CVD) remains a leading cause of death globally. Understanding and characterizing the biochemical context of the cardiovascular system in health and disease is a necessary preliminary step for developing novel therapeutic ...
Aaron H. Wasserman +2 more
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Heartbreak hotel: a convergence in cardiac regeneration [PDF]
, 2016 In February 2016, the Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on ‘Transdifferentiation and Tissue Plasticity in Cardiovascular
Schneider, MD
core +1 more source
Molecular Biomedicine, 2022 Cancer metastasis is the primary cause of the high mortality rate among human cancers. Efforts to identify therapeutic agents targeting cancer metastasis frequently fail to demonstrate efficacy in clinical trials despite strong preclinical evidence ...
Jerry Xiao +11 more
doaj +1 more source
Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]
, 2014 The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L. +8 more
core +6 more sources
Copy number variations in healthy subjects. Case study: iPSC line CSSi005-A (3544) production from an individual with variation in 15q13.3 chromosome duplicating gene CHRNA7 [PDF]
, 2018 CHRNA7, encoding the neuronal alpha7 nicotinic acetylcholine receptor (a7nAChR), is highly expressed in the brain, particularly in the hippocampus. It is situated in the 15q13.3 chromosome region, frequently associated with a Copy Number Variation (CNV),
Altieri, Filomena +13 more
core +1 more source
Reprogramming a Broken Heart [PDF]
Cell Stem Cell, 2012 Fibrosis resulting from cardiac injury presents a major challenge to restoring heart function after myocardial infarction. Two recent papers in Nature report successful in vivo reprogramming of fibroblasts to cardiomyocytes in injured mouse hearts (Qian et al., 2012; Song et al., 2012), resulting in improved cardiac function and reduced scar formation.
Emil M. Hansson, Kenneth R. Chien
openaire +3 more sources
Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]
, 2015 Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom +2 more
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Reprogramming of fatty acid metabolism in cancer
British Journal of Cancer, 2019 A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival.
Nikos Koundouros, G. Poulogiannis
semanticscholar +1 more source
In the heart of the in vivo reprogramming [PDF]
Stem Cell Investigation, 2018 Myocardial infarction (MI) is caused by the occlusion of coronary arteries in the heart leading to an oxygen supply-demand imbalance in the myocardium, eventually causing ischemia of the perfused tissue that—if prolonged—leads to myocardial cell death.
Sampaolesi, Maurilio +2 more
openaire +4 more sources
Regenerative Medicine for the Aging Brain [PDF]
, 2014 In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during ...
Goya, Rodolfo Gustavo +3 more
core +2 more sources