Results 111 to 120 of about 358,538 (335)

Overexpression of Lin28a blocks mitochondrial respiration and promotes Glycolysis to induce chondrocyte reprogramming

, 2022
Zohra Bouchemla, Yohan Jouan, Lucie Orliaguet, Fawaz Alzaïd, Hang‐Korng Ea, Martine Cohen‐Solal, Eric Haÿ   +6 more
openalex   +1 more source

Reprogramming the Genetic Code [PDF]

Science, 2011
Incorporating unnatural amino acids into proteins presents challenges in expanding the genetic code.
openaire   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Inhibition of Polo-like Kinase 1 Prevents the Male Pronuclear Formation Via Alpha-tubulin Recruiting in In Vivo-fertilized Murine Embryos

Journal of Animal Reproduction and Biotechnology, 2018
Polo-like kinase 1 (Plk1) has been known to be a critical element in cell division including centrosome maturation, cytokinesis and spindle formation in somatic, cancer, and mammalian embryonic cells.
Jeonghyeon Moon, Sangho Roh
doaj   +1 more source

DNA Methylation-Reprogrammed Ang II (Angiotensin II) Type 1 Receptor-Early Growth Response Gene 1-Protein Kinase C ε Axis Underlies Vascular Hypercontractility in Antenatal Hypoxic Offspring [PDF]

, 2020
Ting Xu, Xiaorong Fan, Meng Zhao, Meng Wu, Huan Li, Bingyu Ji, Xiaolin Zhu, Ling‐Jun Li, Hongmei Ding, Miao Sun, Zhice Xu, Qinqin Gao   +11 more
openalex   +1 more source

Correction: Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer [PDF]

, 2021
Marco Ruella, Valentina Bertaina, Franco Locatelli, Antonio Camera, Biagio De Angelis, Francesca Del Bufalo, Concetta Quintarelli, Pietro Merli, Marika Guercio, Simona Manni, Iolanda Boffa, Matilde Sinibaldi, Stefano Di Cecca, Simona Caruso, Zeinab Abbaszadeh, Biancamaria Cembrola, Roselia Ciccone, Alberto Órfão, Lourdes Martín‐Martín, Sara Gutiérrez-Herrero, María Herrero, Giovanni Cazzaniga, Vittorio Nunes, Simona Songia, Paolo Marcatili, Frederikke Isa Marin, Luciana Vinti, Mattia Algeri   +27 more
openalex   +1 more source

Managing at the Speed of Light: Improving Mission-Support Performance [PDF]

, 2009
The House and Senate Energy and Water Development Appropriations Subcommittees requested this study to help DOE's three major mission-support organizations improve their operations to better meet the current and future needs of the department.
Allan Burman, C. Morgan Kinghorn, Deborah J. Spero, Dwight A. Ink, Howard M. Messner, Janice Lachance, Jonathan A. Breul, Peter W. Marshall   +7 more
core  

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Transcriptome Analyses in Adult Olive Trees Indicate Acetaldehyde Release and Cyanide-Mediated Respiration Traits as Critical for Tolerance against Xylella fastidiosa and Suggest AOX Gene Family as Marker for Multiple-Resilience

Pathogens
Xylella fastidiosa (Xf) is a global bacterial threat for a diversity of plants, including olive trees. However, current understanding of host responses upon Xf-infection is limited to allow early disease prediction, diagnosis, and sustainable strategies ...
Birgit Arnholdt-Schmitt, Debabrata Sircar, Shahid Aziz, Thais Andrade Germano, Karine Leitão Lima Thiers, Carlos Noceda, Revuru Bharadwaj, Gunasekaran Mohanapriya, José Hélio Costa   +8 more
doaj   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source