Results 11 to 20 of about 179,331 (295)
Macrophage reprogramming for therapy [PDF]
Immunology, 2021 SummaryDysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To date, most strategies employed have been focusing on the modification of T lymphocytes, and although remarkable improvement has been obtained, results often fall short of the intended outcome. Recent
Natacha Ipseiz +4 more
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"Nuclear Reprogramming" and "Epigenetic Reprogramming"
Journal of Mammalian Ova Research, 2004 Takashi Tada +2 more
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Cell Cycle, 2004 The diversity of activators and targets of the NF-kappaB transcription factor family demands that there be regulatory mechanisms in place to control the specificity with which genes under their control are induced. In part this can be achieved through selective induction of different NF-kappaB subunits and through co-operative interactions with ...
Kirsteen J. Campbell, Neil D. Perkins
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Fission for reprogramming [PDF]
Cell Cycle, 2016 The OSKM (Oct3/4, Sox2, Klf4, and c-Myc) factors trigger a complex array of signals that promote the reprogramming of somatic cells.
Juan Pablo Muñoz +2 more
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The XEN of reprogramming [PDF]
Cell Research, 2016 Reprogramming to pluripotency has thus far required complex procedures involving nuclear transfer, cell fusion or genetic manipulation. Two recent papers from Hongkui Deng's group now show various cell types can be reprogrammed simply by chemicals through an extraembryonic endoderm-like phase instead of the primitive streak-like mesendoderm induced by ...
Ergin Beyret +1 more
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Cell Research, 2010 Five decades of nuclear transfer (NT) experiments have established a key principle in developmental genetics - despite vast functional differences, virtually all of the cells in an adult organism maintain an identical genome 1. Studies in several species have shown that the nucleus of a differentiated cell can be reprogrammed by exposure to egg ...
Suneet Agarwal, George Q. Daley
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Stem Cell Research, 2014 Despite advances in the field of somatic cell reprogramming, an understanding and exploration of the underlying mechanisms governing this process are only recently emerging. It is now increasingly apparent that key sequential events correlate with the reprogramming process; a process previously thought to be random and unpredictable is now looking, to ...
Laurent David +3 more
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Strategies for in vivo reprogramming [PDF]
Current Opinion in Cell Biology, 2019 Reprogramming has the potential to provide specific cell types for regenerative medicine applications aiming at replacing tissues that have been lost or damaged due to degenerative diseases and injury. In this review we discuss the latest strategies and advances of in vivo reprogramming to convert cell identities in living organisms, including ...
Ofenbauer, Andreas, Tursun, Baris
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The Journal of Cell Biology, 2004 Does the Kaposi sarcoma (KS) herpesvirus (KSHV) replicate in lymphatic endothelial cells (LECs) or blood vascular endothelial cells (BECs)? Two groups have come up with a surprising answer to this question: neither. Instead the oncogenic virus modifies both of the two cell types to an intermediate state that better suits the virus' replicative needs.
William A. Wells
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Reprogramming by persisters [PDF]
Nature Reviews Microbiology, 2018 This study shows that in the non-growing, antibiotic-tolerant state, Salmonella enterica subsp. enterica serovar Typhimurium actively subverts host cells to promote survival during antibiotic exposure, persistent infections and long-term survival.
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