Results 11 to 20 of about 169,054 (174)
Stem Cell Research & Therapy, 2022 Background Bone has important functions in the body. Several researchers have reported that the polysaccharides and lipopolysaccharide derived from microbes can promote osteogenic differentiation of stem cells.
Hyewon Kim +6 more
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Multiplexed promoterless gene expression with CRISPReader
Genome Biology, 2019 Background Genes are comprised of DNA codes and contain promoters and other control elements for reading these codes. The rapid development of clustered regularly interspaced short palindromic repeats (CRISPR) technology has made possible the ...
Hengji Zhan +5 more
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Model Reprogramming: Resource-Efficient Cross-Domain Machine Learning [PDF]
arXiv, 2022 In data-rich domains such as vision, language, and speech, deep learning prevails to deliver high-performance task-specific models and can even learn general task-agnostic representations for efficient finetuning to downstream tasks. However, deep learning in resource-limited domains still faces multiple challenges including (i) limited data, (ii ...
arxiv
The Journal of Reproduction and Development, 2019 Historically, it had been widely accepted that the female mammalian ovary contained a limited number of oocytes that would reduce over time, without the possibility of replenishment. However, recent studies have suggested that female germline stem cells (
Huy-Hoang NGUYEN +4 more
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CLR: Channel-wise Lightweight Reprogramming for Continual Learning [PDF]
arXiv, 2023 Continual learning aims to emulate the human ability to continually accumulate knowledge over sequential tasks. The main challenge is to maintain performance on previously learned tasks after learning new tasks, i.e., to avoid catastrophic forgetting.
arxiv
Epigenetic landscapes explain partially reprogrammed cells and identify key reprogramming genes [PDF]
Lang AH, Li H, Collins JJ, Mehta P (2014) Epigenetic Landscapes
Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes.
PLoS Comput Biol 10(8): e1003734. doi:10.1371/journal.pcbi.1003734, 2012 A common metaphor for describing development is a rugged "epigenetic landscape" where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly constructing epigenetic landscapes that combines genomic data with techniques from spin-glass physics.
arxiv +1 more source
Epigenetic impairments in development of parthenogenetic preimplantation mouse embryos
The Journal of Reproduction and Development, 2018 Parthenogenesis is an activation process of oocytes that occur without the participation of sperm. Evidence suggests that normal development of embryos requires proper expression of several imprinted genes inherited from both the paternal and maternal ...
Ngan Thi Kim HO +3 more
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Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals
Genome Biology, 2021 Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon +13 more
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Cells, 2023 Autophagy–the lysosomal degradation of cytoplasm–plays a central role in cellular homeostasis and protects cells from potentially harmful agents that may accumulate in the cytoplasm, including pathogens, protein aggregates, and dysfunctional organelles ...
Yan Zhen, Harald Stenmark
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Why Adversarial Reprogramming Works, When It Fails, and How to Tell the Difference [PDF]
arXiv, 2021 Adversarial reprogramming allows repurposing a machine-learning model to perform a different task. For example, a model trained to recognize animals can be reprogrammed to recognize digits by embedding an adversarial program in the digit images provided as input. Recent work has shown that adversarial reprogramming may not only be used to abuse machine-
arxiv