Results 21 to 30 of about 376,055 (402)
Metabolic reprogramming and cancer progression
Science, 2020 Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al.
B. Faubert +2 more
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Fission for reprogramming [PDF]
Cell Cycle, 2016 The OSKM (Oct3/4, Sox2, Klf4, and c-Myc) factors trigger a complex array of signals that promote the reprogramming of somatic cells.
Juan Pablo Muñoz +2 more
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ATPase activity of DFCP1 controls selective autophagy
Nature Communications, 2023 Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER)
Viola Nähse +11 more
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Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
International Journal of Molecular Sciences, 2022 Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product.
Lihua Chen +5 more
semanticscholar +1 more source
Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. [PDF]
, 2016 Great progress has been made regarding the capabilities to modify somatic cell fate ever since the technology for generation of induced pluripotent stem cells (iPSCs) was discovered in 2006.
Biswas, Sangita +3 more
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Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes
Pharmacology Research & Perspectives, 2022 CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs.
Shota Okuyama +5 more
doaj +1 more source
The XEN of reprogramming [PDF]
Cell Research, 2016 Reprogramming to pluripotency has thus far required complex procedures involving nuclear transfer, cell fusion or genetic manipulation. Two recent papers from Hongkui Deng's group now show various cell types can be reprogrammed simply by chemicals through an extraembryonic endoderm-like phase instead of the primitive streak-like mesendoderm induced by ...
Ergin Beyret +1 more
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Metabolic reprogramming in macrophage responses
Biomarker Research, 2021 Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment ...
Yang Liu +9 more
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Cell Research, 2010 Five decades of nuclear transfer (NT) experiments have established a key principle in developmental genetics - despite vast functional differences, virtually all of the cells in an adult organism maintain an identical genome 1. Studies in several species have shown that the nucleus of a differentiated cell can be reprogrammed by exposure to egg ...
Suneet Agarwal, George Q. Daley
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Journal of experimental & clinical cancer research : CR, 2021 Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have not yielded success.
S. Dong +12 more
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