Results 21 to 30 of about 338,803 (187)
Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]
, 2017 Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J +15 more
core +4 more sources
Fission for reprogramming [PDF]
Cell Cycle, 2016 The OSKM (Oct3/4, Sox2, Klf4, and c-Myc) factors trigger a complex array of signals that promote the reprogramming of somatic cells.
Juan Pablo Muñoz, Antonio Zorzano
openaire +2 more sources
Co-expression networks in generation of induced pluripotent stem cells. [PDF]
, 2016 We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni +6 more
core +2 more sources
Rejuvenation by cell reprogramming: A new horizon in gerontology [PDF]
, 2018 The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here,
Brown, Oscar Alfredo +5 more
core +2 more sources
Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]
, 2017 In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core +1 more source
Induced neuronal reprogramming [PDF]
Journal of Comparative Neurology, 2014 ABSTRACTCellular differentiation processes during normal embryonic development are guided by extracellular soluble factors such as morphogen gradients and cell contact signals, eventually resulting in induction of specific combinations of lineage‐determining transcription factors.
Cheen Euong, Ang, Marius, Wernig
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GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]
, 2013 Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes +6 more
core +1 more source
Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]
, 2016 Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P +9 more
core +3 more sources
Bmi1 puSHHes reprogramming [PDF]
Cell Research, 2011 In 2006, the group of Shinya Yamanaka demonstrated that somatic cells could be reprogrammed into induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors associated to stemness: Oct4, Sox2, Klf4 and c-Myc 1. This groundbreaking discovery opened the possibility of generating patient-specific cells for research, drug ...
Han Li, Manuel Serrano
openaire +2 more sources
Multiplexed promoterless gene expression with CRISPReader
Genome Biology, 2019 Background Genes are comprised of DNA codes and contain promoters and other control elements for reading these codes. The rapid development of clustered regularly interspaced short palindromic repeats (CRISPR) technology has made possible the ...
Hengji Zhan +5 more
doaj +1 more source