Results 21 to 30 of about 169,054 (174)

Using single-cell entropy to describe the dynamics of reprogramming and differentiation of induced pluripotent stem cells [PDF]

, 2020
Induced pluripotent stem cells (iPSCs) provide a great model to study the process of reprogramming and differentiation of stem cells. Single-cell RNA sequencing (scRNA-seq) enables us to investigate the reprogramming process at single-cell level. Here, we introduce single-cell entropy (scEntropy) as a macroscopic variable to quantify the cellular ...
arxiv   +1 more source

Improving porcine in vitro blastocyst development using fetal bovine serum, amino acids, and insulin-transferrin-selenium

The Journal of Reproduction and Development
In vitro production of porcine-hatched blastocysts is important for various applications. However, the mechanobiology of blastocoel expansion and hatching remains poorly understood.
Ba Anh My LE, Lien Boi Linh NGUYEN, Chi Thien LAM, Nhat-Thinh NGUYEN, Ngoc Thao Vy NGUYEN, Van Thuan NGUYEN, Hong-Thuy BUI   +6 more
doaj   +1 more source

High Therapeutic and Esthetic Properties of Extracellular Vesicles Produced from the Stem Cells and Their Spheroids Cultured from Ocular Surgery-Derived Waste Orbicularis Oculi Muscle Tissues

Antioxidants, 2021
Extracellular vesicles (EVs) are paracrine factors that mediate stem cell therapeutics. We aimed at evaluating the possible therapeutic and esthetic applications of EVs prepared from the waste human facial tissue-derived orbicularis oculi muscle stem ...
Kyung Min Lim, Ahmed Abdal Dayem, Yujin Choi, Yoonjoo Lee, Jongyub An, Minchan Gil, Soobin Lee, Hee Jeong Kwak, Balachandar Vellingirl, Hyun Jin Shin, Ssang-Goo Cho   +10 more
doaj   +1 more source

Deep Graph Reprogramming [PDF]

arXiv, 2023
In this paper, we explore a novel model reusing task tailored for graph neural networks (GNNs), termed as "deep graph reprogramming". We strive to reprogram a pre-trained GNN, without amending raw node features nor model parameters, to handle a bunch of cross-level downstream tasks in various domains.
arxiv  

Anti-Cancer Effects of Lactobacillus plantarum L-14 Cell-Free Extract on Human Malignant Melanoma A375 Cells

Molecules, 2020
Human malignant melanoma is the most aggressive type of skin cancer with high metastatic ability. Despite several traditional therapies, the mortality rate remains high. Lactobacillus plantarum (L.
Jaehyun Park, Mijin Kwon, Jaehoon Lee, Sangkyu Park, Jeongmin Seo, Sangho Roh   +5 more
doaj   +1 more source

Cell reprogramming modelled as transitions in a hierarchy of cell cycles [PDF]

J. Phys. A: Math. Theor. 50 (2017) 425601 (23pp), 2016
We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing ...
arxiv   +1 more source

Synthetic Tet-inducible artificial microRNAs targeting β-catenin or HIF-1α inhibit malignant phenotypes of bladder cancer cells T24 and 5637

Scientific Reports, 2015
Ribonucleic acid interference (RNAi) based on microRNA (miRNA) may provide efficient and safe therapeutic opportunities. However, natural microRNAs can not easily be regulated and usually cause few phenotypic changes.
Yonghao Zhan, Yuchen Liu, Junhao Lin, Xing Fu, Chengle Zhuang, Li Liu, Wen Xu, Jianfa Li, Mingwei Chen, Guoping Zhao, Weiren Huang, Zhiming Cai   +11 more
doaj   +1 more source

Adversarial Reprogramming Revisited [PDF]

arXiv, 2022
Adversarial reprogramming, introduced by Elsayed, Goodfellow, and Sohl-Dickstein, seeks to repurpose a neural network to perform a different task, by manipulating its input without modifying its weights. We prove that two-layer ReLU neural networks with random weights can be adversarially reprogrammed to achieve arbitrarily high accuracy on Bernoulli ...
arxiv  

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding

Nature Communications
Overexpression of the transmembrane matrix metalloproteinase MT1-MMP/MMP14 promotes cancer cell invasion. Here we show that MT1-MMP-positive cancer cells turn MT1-MMP-negative cells invasive by transferring a soluble catalytic ectodomain of MT1-MMP ...
Eva Maria Wenzel, Nina Marie Pedersen, Liv Anker Elfmark, Ling Wang, Ingrid Kjos, Espen Stang, Lene Malerød, Andreas Brech, Harald Stenmark, Camilla Raiborg   +9 more
doaj   +1 more source

Theophylline controllable RNAi-based genetic switches regulate expression of lncRNA TINCR and malignant phenotypes in bladder cancer cells

Scientific Reports, 2016
TINCR is a well-known lncRNA which acts as a master regulator in somatic differentiation development. However, it is still unclear whether TINCR is also involved in caner occurrence and progression.
Zhicong Chen, Yuchen Liu, Anbang He, Jianfa Li, Mingwei Chen, Yonghao Zhan, Junhao Lin, Chengle Zhuang, Li Liu, Guoping Zhao, Weiren Huang, Zhiming Cai   +11 more
doaj   +1 more source