Results 21 to 30 of about 403,028 (282)
ATPase activity of DFCP1 controls selective autophagy
Nature Communications, 2023 Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER)
Viola Nähse +11 more
doaj +1 more source
Nature Communications, 2021 Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.
Kay Oliver Schink +9 more
doaj +1 more source
Deepening the understanding of CNVs on chromosome 15q11–13 by using hiPSCs: An overview
Frontiers in Cell and Developmental Biology, 2023 The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is widely expressed in the central and peripheral nervous systems. This receptor is implicated in both brain development and adult neurogenesis thanks to its ability to mediate ...
Angela Maria Giada Giovenale +11 more
doaj +1 more source
Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
International Journal of Molecular Sciences, 2022 Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product.
Lihua Chen +5 more
semanticscholar +1 more source
Scientific Reports, 2023 Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting chemicals (EDCs) are active substances that interfere with hormonal signaling. Among EDCs,
Andrea Di Credico +6 more
doaj +1 more source
Cell Cycle, 2004 The diversity of activators and targets of the NF-kappaB transcription factor family demands that there be regulatory mechanisms in place to control the specificity with which genes under their control are induced. In part this can be achieved through selective induction of different NF-kappaB subunits and through co-operative interactions with ...
Kirsteen J. Campbell, Neil D. Perkins
openalex +3 more sources
Transient naive reprogramming corrects hiPS cells functionally and epigenetically
Nature, 2023 A new reprogramming strategy used to produce human induced pluripotent stem cells from somatic cells results in epigenetic and functional profiles that are highly similar to those of human embryonic stem cells.
S. Buckberry +23 more
semanticscholar +1 more source
Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes
Pharmacology Research & Perspectives, 2022 CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs.
Shota Okuyama +5 more
doaj +1 more source
Metabolic reprogramming and cancer progression
Science, 2020 Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al.
B. Faubert +2 more
semanticscholar +1 more source
The cancer metabolic reprogramming and immune response
Molecular Cancer, 2021 The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining ...
Longzheng Xia +18 more
semanticscholar +1 more source