Results 81 to 90 of about 403,028 (282)
Metabolic Reprogramming in Glioma [PDF]
Frontiers in Cell and Developmental Biology, 2017 Many cancers have long been thought to primarily metabolize glucose for energy production-a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the early twentieth century. Yet cancer cells also utilize other substrates, such as amino acids and fatty acids, to produce raw materials for cellular maintenance and energetic
Elizabeth A. Stoll, Marie Strickland
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Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
Nature CommunicationsOverexpression of the transmembrane matrix metalloproteinase MT1-MMP/MMP14 promotes cancer cell invasion. Here we show that MT1-MMP-positive cancer cells turn MT1-MMP-negative cells invasive by transferring a soluble catalytic ectodomain of MT1-MMP ...
Eva Maria Wenzel +9 more
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Flexible Sensor Network Reprogramming for Logistics [PDF]
, 2007 Besides the currently realized applications, Wireless Sensor Networks can be put to use in logistics processes. However, doing so requires a level of flexibility and safety not provided by the current WSN software platforms.
Evers, L., Havinga, P.J.M., Kuper, J.
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Scientific Reports, 2015 Ribonucleic acid interference (RNAi) based on microRNA (miRNA) may provide efficient and safe therapeutic opportunities. However, natural microRNAs can not easily be regulated and usually cause few phenotypic changes.
Yonghao Zhan +11 more
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Partial Trajectory: The Story of the Altered Nuclear Transfer-Oocyte Assisted Reprogramming (ANT-OAR) Proposal [PDF]
, 2007 This essay aims to tell the story of the “altered nuclear transfer-oocyte assisted reprogramming,” or ANT-OAR, proposal—from its conception by Professor William Hurlbut of the President’s Council on Bioethics—to its adoption and promotion by a group of ...
Byrnes, W. Malcolm
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Pharmaceutics, 2022 The constant changes in cancer cell bioenergetics are widely known as metabolic reprogramming. Reprogramming is a process mediated by multiple factors, including oncogenes, growth factors, hypoxia-induced factors, and the loss of suppressor gene function,
Carla Navarro +8 more
semanticscholar +1 more source
Cold Spring Harbor Perspectives in Biology, 2014 Nuclear reprogramming technology was first established more than 50 years ago. It can rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new pluripotent order. The recent discovery reviewed here that induced pluripotency can be achieved by a small set of transcription factors has opened up unprecedented opportunities in ...
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The labyrinth of nuclear reprogramming [PDF]
Journal of Molecular Cell Biology, 2011 One of the current chief goals of regenerative medicine involves finding a way to overcome the lack of efficient treatments for thousands of diseases. Recently, increasing evidence indicates that genetic defects observed in patient somatic cells could be erased and/or alleviated by direct reprogramming toward pluripotency and recapitulated upon ...
Sancho-Martinez, Ignacio +2 more
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Myeloprotection by Cytidine Deaminase Gene Transfer in Antileukemic Therapy
Neoplasia: An International Journal for Oncology Research, 2013 Gene transfer of drug resistance (CTX-R) genes can be used to protect the hematopoietic system from the toxicity of anticancer chemotherapy and this concept recently has been proven by overexpression of a mutant O6-methylguaninemethyltransferase in the ...
Nico Lachmann +5 more
doaj +1 more source
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
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