Results 51 to 60 of about 2,222,500 (385)
Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]
, 2013 Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter +2 more
core +2 more sources
Química Nova, 2008 The discussion among teachers, students, and technicians about the destination of residues from chemistry laboratories led to a research project whose results were incorporated into a course in its daily practices.
Regina Felisberto +6 more
doaj +1 more source
Unraveling the Differences of the Hydrolytic Activity of Trypanosoma cruzi trans-Sialidase and Trypanosoma rangeli Sialidase: A Quantum Mechanics–Molecular Mechanics Modeling Study [PDF]
, 2014 Chagas’ disease, also known as American trypanosomiasis, is a lethal, chronic disease that currently affects more than 10 million people in Central and South America. The trans-sialidase from Trypanosoma cruzi (T. cruzi, TcTS) is a crucial enzyme for the
Bueren Calabuig, Juan A. +2 more
core +1 more source
Peripherally-metallated porphyrins: meso-n1-porphyrinyl-platinum(II) complexes of 5,15-diaryl- and 5,10,15-triarylporphyrins [PDF]
, 2002 Attempted metathesis reactions of peripherally-metallated meso-η1-porphyrinylplatinum(II) complexes such as trans-[PtBr(NiDPP)(PPh3)2] (H2DPP = 5,15-diphenylporphyrin) with organolithium reagents fail due to competitive addition at the porphyrin ring ...
Arnold, Dennis +2 more
core +2 more sources
Molecules, 2013 A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines ...
Cheng-Ting Zi +7 more
doaj +1 more source
Small Structures, 2023 A novel recycling process of the conductive agent in spent lithium iron phosphate batteries is demonstrated. Wet chemistry is applied in recovering lithium and iron phosphate, and the filter residue is calcined with a small amount of recovered iron ...
Kun Luo +7 more
doaj +1 more source
Functional differences of iodinated obestatin peptides: in vitro metabolic stability profile [PDF]
, 2010 Peptides are small polymers of 50 amino acids, situated between organic molecules and proteins. Most peptides perform a biochemical-physical function and are therefore considered as potential drugs.
De Spiegeleer, Bart +2 more
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
EFFECT OF RESIDUAL EFFECTIVE ALKALI ON EUCALYPTUS KRAFT PULP YIELD AND CHEMISTRY [PDF]
CERNE, 2018 ABSTRACT The impact of residual effective alkali (REA) and pulp delignification degree on Eucalyptus kraft pulp yield and chemistry was investigated. In this study four types of eucalypt clones were evaluated. The eucalypt woods were cooked to kappa numbers of 14±1, 18±1, 22±1 and 26±1 using two different ranges of REA, namely: low-REA (1-2 g.L-1) and ...
Robisnéa Adriana Ribeiro +2 more
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source