Results 101 to 110 of about 512,165 (310)

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Novel continuous experimental evolution methodology uncovers rapid resistance development and cross-resistance

npj Antimicrobials and Resistance
Antimicrobial resistance poses a significant global health threat. Experimental evolution studies are crucial in understanding resistance mechanisms and thereby informing strategies to preserve antibiotic efficacy.
Thaddäus Echelmeyer, Markus Ellmann, Stefan E. Heiden, Kaan Kocer, Michael Schwabe, Helmut Fickenscher, Gregor Maschkowitz, Sebastian Guenther, Dennis Nurjadi, Katharina Schaufler, Elias Eger   +10 more
doaj   +1 more source

Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain

Frontiers in Cellular and Infection Microbiology
BackgroundConvergence of Klebsiella pneumoniae (KP) pathotypes has been increasingly reported in recent years. These pathogens combine features of both multidrug-resistant and hypervirulent KP.
Justus U. Müller, Michael Schwabe, Lena-Sophie Swiatek, Stefan E. Heiden, Rabea Schlüter, Max Sittner, Jürgen A. Bohnert, Karsten Becker, Evgeny A. Idelevich, Evgeny A. Idelevich, Sebastian Guenther, Elias Eger, Katharina Schaufler, Katharina Schaufler   +13 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Exploiting evolution to treat drug resistance: Combination therapy and the double bind [PDF]

, 2011
Although many anti cancer therapies are successful in killing a large percentage of tumour cells when initially administered, the evolutionary dynamics underpinning tumour progression mean that often resistance is an inevitable outcome, allowing for new ...
Alexander R. A. Anderson, David Basanta, Robert Gatenby   +2 more
core   +2 more sources

Pattern Formation in Non‐Equilibrium Architected Materials

Advanced Materials Technologies, EarlyView.
This article demonstrates an artificial mechanical system ‐ a robotic metamaterial ‐ as an accessible and versatile platform within which to explore and prescribe the reaction‐diffusion driven pattern formation hitherto associated with comparatively less accessible and versatile non‐equilibrium biological and chemical systems.
Vinod Ramakrishnan, Michael J. Frazier
wiley   +1 more source

Forest Net Primary Production Resistance Across a Gradient of Moderate Disturbance [PDF]

, 2014
The global carbon (C) balance is vulnerable to disturbances that alter terrestrial C uptake and loss. Moderate disturbances that kill or defoliate only a subset of canopy trees such as insect defoliation, drought, and age-related senescence are ...
Goodrich-Stuart, Ellen
core   +1 more source

Anti‐Slip Material‐Based Strategies and Approaches

Advanced Materials Technologies, EarlyView.
This review highlights the principle mechanisms of slipping at the microscale, linking contact mechanics with a friction behavior model for surface interfaces. Main strategies to develop anti‐slip properties to the surfaces are discussed alongside standardized testing approaches.
Sogand Abbaspoor‐Zanjani, Carlo Antonini, Teresa Gatti, Mengjiao Wang   +3 more
wiley   +1 more source

Micropillar‐Engineered Hybrid Adhesive Patch for Surface‐Conformable and Directional Adhesion

Advanced Materials Technologies, EarlyView.
This work presents a surface‐conformable hybrid adhesive integrating height‐optimized hexagonal micropillars with open‐rectangular cuts. The micropillars enhance rough‐surface contact and microscale crack arrest, while the cuts guide and reverse interfacial cracks for strong and directional adhesion. The multiscale architecture achieves robust pull‐off
Seongjin Park, Dong Kwan Kang, Haejin Bae, Ho‐Sup Jung, Hoon Eui Jeong   +4 more
wiley   +1 more source

Multidrug-resistant high-risk clonal Escherichia coli lineages occur along an antibiotic residue gradient in the Baltic Sea

npj Clean Water
The global spread of multidrug-resistant Escherichia coli threatens human, animal, and environmental health. Despite the recognition of water bodies as potential reservoirs, research on antimicrobial resistance (AMR) and antibiotic residues in the Baltic
Phillip Lübcke, Stefan E. Heiden, Timo Homeier-Bachmann, Jürgen A. Bohnert, Christian Schulze, Elias Eger, Michael Schwabe, Sebastian Guenther, Katharina Schaufler   +8 more
doaj   +1 more source