Results 41 to 50 of about 86,799,447 (290)

Thyroid Hormone Plays an Important Role in Cardiac Function: From Bench to Bedside

Frontiers in Physiology, 2021
Thyroid hormones (THs) are synthesized in the thyroid gland, and they circulate in the blood to regulate cells, tissues, and organs in the body. In particular, they exert several effects on the cardiovascular system.
Hiroyuki Yamakawa, Hiroyuki Yamakawa, Tomoko S. Kato, Jaeduk Yoshimura Noh, Shinsuke Yuasa, Akio Kawamura, Keiichi Fukuda, Yoshiyasu Aizawa   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Associations between the levels of thyroid hormones and abdominal obesity in euthyroid post-menopausal women

Endokrynologia Polska, 2020
INTRODUCTION: The aim of this study was to explore the association between thyroid hormones and abdominal fat quantities in euthyroid post-menopausal women.
Qiu Yang, Yan Hai Wan, Sheng De Hu, Yi Hong Cao   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]

, 2015
The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Farjo, Nilofer, Haslam, Iain S., Hardman, Jonathan A., Paus, Ralf, Farjo, Bessam   +4 more
core   +5 more sources

THE INFLUENCE OF CARBIMAZOLE ON SERUM LEPTIN HORMONE AND INSULIN RESISTANCE IN PATIENTS WITH HYPERTHYROIDISM

Zanco Journal of Pure and Applied Sciences, 2019
Carbimazole is one of the common antithyroid drugs for the treatment of hyperthyroidism. It interferes with the synthesis of thyroid hormones and results in the reducing of thyroid hormones level.
Bnar S Shexane, Muslih A. Ibrahim
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Relationship of thyroid hormones and metabolic parameters in euthyroid women

Turkish Journal of Family Practice
Objective: Thyroid hormones play a role in metabolic regulation, yet their associations with obesity and insulin resistance in euthyroid individuals remain unclear. This study aimed to evaluate the relationship between thyroid-stimulating hormone (TSH),
Fatma Nur Yürekten Sıcakyüz, Furkan Alp Eren, Kağan Güngör, Hacer Hicran Mutlu   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

miR-191 downregulation plays a role in thyroid follicular tumors through CDK6 targeting [PDF]

, 2010
miR-191 expression is frequently altered in several neoplasias, being upregulated in some, such as pancreatic, colon, lung and prostate carinomas, and downregulated in others, such as severe medulloblastomas and melanomas.
Colamaio, Marianna
core   +1 more source