Results 51 to 60 of about 90,229,355 (301)

Disfunción tiroidea y trastornos del ánimo: revisión del estado del arte

Revista Médica Clínica Las Condes, 2020
Resumen: La relación entre función tiroidea y trastornos del ánimo se ha observado desde hace más de 50 años. Las hormonas tiroideas, actúan en el cerebro modulando génicamente proteínas asociadas a la fisiopatología de los trastornos del ánimo y ...
Constanza Caneo, Igor Aedo, María José Riquelme, Carlos Fardella   +3 more
doaj   +1 more source

Age-related thyroid hormone resistance: A friend or foe

Endocrine and Metabolic Science, 2023
Clinical experience shows that older people with hyperthyroidism display fewer signs or symptoms compared to younger people with hyperthyroidism.
Arshag D. Mooradian
doaj   +1 more source

Syndrome of Resistance to Thyroid Hormone: Insights into Thyroid Hormone Action

Experimental Biology and Medicine, 1996
Thyroid hormones (T3, T4) exert multiple cellular effects through nuclear thyroid hormone receptors (TR alpha, TR beta). Thyroid hormone receptors are transcription factors that act by altering patterns of gene expression. Resistance to thyroid hormone (RTH) is a rare disorder caused by mutations in the TR beta gene.
P, Kopp, K, Kitajima, J L, Jameson
openaire   +2 more sources

A Rare Case of Partial Peripheral Thyroid Hormone Resistance Due to a Point Mutation in the Membrane Integrin Α(V)Β(3) and Concomitant Hashimoto`s Thyroiditis

, 2019
BACKGROUND: Peripheral resistance to thyroid hormones is a type of unresponsiveness of the peripheral cells or tissues to FT3 and/or FT4. Generalised resistance to thyroid hormones affects the pituitary gland and most of the peripheral tissues. Selective
Manevska, Nevena, Savovska, Martina, Stojanoski, Sinisa   +2 more
core   +1 more source

Thyroid hormones in diabetes, cancer, and aging [PDF]

, 2020
Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and human research have determined that thyroid hormones modulate cellular processes relevant for aging and for the majority of age ...
Gauthier, Benoit R., Martín-Montalvo, Alejandro, Sola-García, Alejandro, Cobo-Vuilleumier, Nadia, Cáliz-Molina, María Ángeles, Benoit R. Gauthier, Nadia Cobo‐Vuilleumier, Alejandro Sola‐García, Lorenzo, Petra Isabel, María Ángeles Cáliz‐Molina, Petra Isabel Lorenzo, Capilla-González, Vivian, Vivian Capilla‐González, Alejandro Martin‐Montalvo, Cáliz Molina, María Ángeles, Sola García, Alejandro, Cobo Vuilleumier, Nadia   +16 more
core   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

A Case of Resistance to Thyroid Hormone with Thyroid Cancer

Journal of Korean Medical Science, 2010
Resistance to thyroid hormone (RTH) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features. The magnitude of RTH is caused by mutations in the thyroid hormone receptor beta (TR beta) gene.
Kim, Hee Kyung, Kim, Doi, Yoo, Eun Hyung, Lee, Ji In, Jang, Hye Won, Tan, Alice Hyun Kyung, Hur, Kyu Yeon, Kim, Jae Hyeon, Kim, Kwang-Won, Chung, Jae Hoon, Kim, Sun Wook   +10 more
openaire   +2 more sources

DataSheet_1_Impaired Sensitivity to Thyroid Hormones Is Associated With Elevated Blood Glucose in Coronary Heart Disease.docx

, 2022
ContextThyroid hormones influence glucose homeostasis through central and peripheral regulation. To date, the association between thyroid hormone sensitivity and elevated blood glucose (EBG) in patients with coronary heart disease (CHD) remains unknown ...
Shan Gao (46743), Lu Yu (74016), Guangwei Pan (10984209), Tong Yang (103174), Lin Li (28817), Qiang Xu (71522), Yanchao Zheng (10839815), Mei Ma (2271595), Jinyu Su (12809764), Chunquan Yu (6569021), Rongrong Yang (477537), Yijia Liu (348194), Yang Wang (5921), Fanfan Liu (1518379), Qi Cheng (46307), Zhu Li (193162), Yuanyuan He (505528)   +16 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Association between sensitivity to thyroid hormone indices and osteoporosis in euthyroid patients with type 2 diabetes mellitus

Therapeutic Advances in Chronic Disease, 2023
Background: Thyroid hormones are known to regulate bone metabolism and may influence bone mineral density (BMD), as well as the risk of osteoporosis (OP) and fractures in patients with type 2 diabetes mellitus (T2DM).
Xuelun Wu, Furui Zhai, Ailing Chang, Jing Wei, Yanan Guo, Jincheng Zhang   +5 more
doaj   +1 more source