Results 51 to 60 of about 86,799,447 (290)

Is there a connection between lithium induced hypothyroidism and lithium efficacy in bipolar disorder?

Dialogues in Clinical Neuroscience & Mental Health, 2018
Hypothyroidism, more commonly subclinical, appears a common abnormality, while the hypothalamic-pituitary-thyroid (HPT) axis abnormalities are quite common among patients with bipolar disorder.
Orestis Giotakos
doaj   +1 more source

Alopecia: Association with Resistance to Thyroid Hormones

Journal of Pediatric Endocrinology and Metabolism, 2009
Resistance to thyroid hormone (RTH) syndrome is caused by thyroid hormone beta receptor (TRbeta) mutations. Goiter, learning disabilities, psychological abnormalities, sinus tachycardia, hearing deficits, short stature, and growth delay are among the most common symptoms in patients with RTH.
Güran, Tülay, Bircan, Rifat, Turan, Serap, Bereket, Abdullah   +3 more
openaire   +5 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19F NMR of Fluoroproline Residues

Angewandte Chemie, EarlyView.
Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene, Mariam Sai, Alexis Jouin, Yves Nominé, Vladimir Torbeev, Bruno Kieffer   +5 more
wiley   +2 more sources

Disfunción tiroidea y trastornos del ánimo: revisión del estado del arte

Revista Médica Clínica Las Condes, 2020
Resumen: La relación entre función tiroidea y trastornos del ánimo se ha observado desde hace más de 50 años. Las hormonas tiroideas, actúan en el cerebro modulando génicamente proteínas asociadas a la fisiopatología de los trastornos del ánimo y ...
Constanza Caneo, Igor Aedo, María José Riquelme, Carlos Fardella   +3 more
doaj   +1 more source

Age-related thyroid hormone resistance: A friend or foe

Endocrine and Metabolic Science, 2023
Clinical experience shows that older people with hyperthyroidism display fewer signs or symptoms compared to younger people with hyperthyroidism.
Arshag D. Mooradian
doaj   +1 more source

Syndrome of Resistance to Thyroid Hormone: Insights into Thyroid Hormone Action

Experimental Biology and Medicine, 1996
Thyroid hormones (T3, T4) exert multiple cellular effects through nuclear thyroid hormone receptors (TR alpha, TR beta). Thyroid hormone receptors are transcription factors that act by altering patterns of gene expression. Resistance to thyroid hormone (RTH) is a rare disorder caused by mutations in the TR beta gene.
P, Kopp, K, Kitajima, J L, Jameson
openaire   +2 more sources

Electrochemical Pathways for Nitrate Conversion to Ammonia: From Environmental Challenges to Ammonia Economy

Advanced Functional Materials, EarlyView.
This perspective presents recent advances in electrocatalytic nitrate reduction, focusing on reaction mechanisms, catalyst design, and electrolyzer configurations. Key challenges in selectivity, stability, and practical wastewater treatment are highlighted, while future directions for advancing sustainable ammonia synthesis and nitrate remediation are ...
Xintong Li, Yunpeng Zuo, Xiaoran Zhang, Jieqiong Shan, Kenneth Mei Yee Leung, Bin Liu, Peter Strasser, Adrian Fisher, Zonglong Zhu, Xin Wang   +9 more
wiley   +1 more source

A Case of Resistance to Thyroid Hormone with Thyroid Cancer

Journal of Korean Medical Science, 2010
Resistance to thyroid hormone (RTH) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features. The magnitude of RTH is caused by mutations in the thyroid hormone receptor beta (TR beta) gene.
Kim, Hee Kyung, Kim, Doi, Yoo, Eun Hyung, Lee, Ji In, Jang, Hye Won, Tan, Alice Hyun Kyung, Hur, Kyu Yeon, Kim, Jae Hyeon, Kim, Kwang-Won, Chung, Jae Hoon, Kim, Sun Wook   +10 more
openaire   +2 more sources