Results 171 to 180 of about 3,559,343 (361)

Evaluation of spa-typing of methicillin-resistant Staphylococcus aureus using high-resolution melting analysis

, 2015
OBJECTIVE: spa-typing of methicillin-resistant Staphylococcus aureus (MRSA) has been widely used in clinical diagnostics and epidemiological studies. We aimed to evaluate high-resolution melting (HRM) as a rapid and cost effective method, to replace DNA ...
Gunnar Sandstrom, Waleed Mazi, Vartul Sangal, Yu, J, Saeed, Amir, Sandstrom, Gunnar, Sangal, Vartul, Sangal, V, Sandstom, Gunnar, Amir Saeed, Mazi, W,, Jun Yu, Sandstrom, G, Saeed, A,, Mazi, Waleed, Yu, Jun   +15 more
core   +1 more source

Sipuleucel-T immunotherapy for castration-resistant prostate cancer.

New England Journal of Medicine, 2010
P. Kantoff, C. Higano, N. Shore, E. Berger, E. Small, D. Penson, C. Redfern, A. Ferrari, R. Dreicer, R. Sims, Yi Xu, M. Frohlich, P. Schellhammer   +12 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Trend-resistant design of experiments under budget constraints. [PDF]

When experiments are to be performed in a time sequence, the observed responses are affected by a time trend. The construction of trend-resistant run orders is extensively described in the literature.
Tack, Lieven, Vandebroek, Martina
core  

Comparative genomics of carbapenem-resistant Acinetobacter baumannii isolated from pediatric patients in a tertiary care hospital

Microbiology Spectrum
Acinetobacter baumannii is a short gram-negative bacillus, notable for its intrinsic multidrug resistance and genomic plasticity, which facilitates the acquisition of additional resistance genes via mobile genetic elements.
Dafne Guillén-Navarro, Sara A. Ochoa, Daniela De La Rosa-Zamboni, Silvia Giono-Cerezo, Juan Xicohtencatl-Cortes, Ariadnna Cruz-Córdova   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Combinations of β-lactam or aminoglycoside antibiotics with plectasin are synergistic against methicillin-sensitive and methicillin-resistant Staphylococcus aureus.

, 2015
Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance. In particular, methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) are prevalent and the ...
Coates Anthony, Alexander Liu (249396), Anthony Coates (362975), Kearns Angela, Yanmin Hu, Hu Yanmin, Vaudrey, J, Christiana Moigboi, Brigita Vaiciunaite, Angela Kearns (225395), Anthony Coates, James Vaudrey (693517), Christiana Moigboi (693519), Sharla M McTavish, Vaudrey James, Vaiciunaite Brigita, Sharla M. McTavish (693520), Liu Alexander, McTavish Sharla M., Vaiciunaite, B, McTavish, SM, Alexander Liu, Yanmin Hu (155376), Hu, Y, Moigboi, C, Moigboi Christiana, Kearns, A, Liu, A, Angela Kearns, James Vaudrey, Coates, A, Brigita Vaiciunaite (693518)   +31 more
core   +1 more source

Doxycycline treatment for drug-resistant Mycoplasma pneumoniae pneumonia and evaluation of key predictive factors for refractory disease

Frontiers in Medicine
ObjectiveMycoplasma pneumoniae pneumonia (MPP) in children is a common respiratory infection, with rising concerns over macrolide-resistant strains. The aim of this study is to establish an effective diagnostic prediction model for refractory MPP (RMPP ...
Ruijuan Ren, Yuping Xu, Xinyan Cui, Mengsheng Zhang, Xiangtao Wu, Tuanjie Wang, Xue Liu, Shujun Li   +7 more
doaj   +1 more source

Deep brain stimulation for treatment-resistant depression.

Neuron, 2005
H. Mayberg, A. Lozano, V. Voon, H. McNeely, D. Seminowicz, C. Hamani, J. Schwalb, S. Kennedy   +7 more
semanticscholar   +1 more source