Results 151 to 160 of about 3,559,343 (361)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

TREATMENT OF RESISTANT AND ULTRA RESISTANT SCHIZOPHRENIA

Psychiatria Danubina, 2021
Schizophrenia is a psychiatric disease which affects one percent of population. It is most common in young adults. It is primarily treated with typical and atypical antipsychotics. Resistant schizophrenia is a condition diagnosed after no response is noticed to two different antipsychotics of which one is atypical.
Medić, Antonija, Herceg, Dora, Herceg, Miroslav   +2 more
openaire   +6 more sources

Prevalence of Methicillin-Resistant Staphylococcus Aureus in El Oro Province, Ecuador

, 2012
Color poster with text, images, tables, and graphs.Methicillin-resistant Staphylococcus aureus (MRSA) is an antibiotic-resistant strain of the bacterium Staphylococcus aureus.
Soderholm, Beatrice R., Monte, Christopher A.   +1 more
core  

Molecular Investigations of Linezolid Resistance in Enterococci OptrA Variants from a Hospital in Shanghai

Infection and Drug Resistance, 2020
Pei Li, Yang Yang, Li Ding, Xiaogang Xu, Dongfang Lin Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Dongfang Lin Tel/ Fax +86-21-52888193Email lindongfang@fudan.edu.cnPurpose: The ...
Li P, Yang Y, Ding L, Xu X, Lin D
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Lancet Respiratory Medicine Commission : 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis

, 2019
: The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was published in 2017, which comprehensively reviewed and provided recommendations on various aspects of the disease.
Dowdy, David, Nuermberger, Eric, Chang, Kwok Chiu, Migliori, G.B., Furin, Jennifer, Limberis, Jason, Menzies, Dick, McIlleron, Helen, Jindani, Amina, Jaramillo, Ernesto, McNerney, Ruth, Nardell, Edward A., Dooley, Kelly E., Schaaf, H. Simon, Barry, Clifton E., Van Rie, Annelies, Ndjeka, Norbert, Keshavjee, Salmaan, Rodrigues, Camilla, Low, Marcus, Lange, Christoph, Padayatchi, Nesri, Nahid, Payam, Nunn, Andrew, Sirgel, Frik A., Warren, Robin M., Udwadia, Zarir F., Lessem, Erica, Maartens, Gary, Horsburgh, C. Robert, Esmail, Aliasgar, Clark, Taane G., Murray, Megan, Seddon, James A., Pasipanodya, Jotam G., Gumbo, Tawanda, Niemann, Stefan, Dheda, Keertan, Churchyard, Gavin J., London, Leslie, Theron, Grant, Fourie, Bernard, Fennelly, Kevin P., Hesseling, Anneke C.   +43 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Molecular biological characterisation of amplified esterases from organophosphate resistant and susceptible 'Culex quinquefasciatus'. [PDF]

Culex mosquitoes, as well as being vectors of filariasis and Japanese encephalitis, are a world wide biting nuisance. Organophosphorus insecticides (OPs) have been widely used to control Culex populations.
Vaughan, Ashley Michael
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source