Results 151 to 160 of about 2,503,389 (311)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Nickel Alloy, Corrosion- and Heat-Resistant, Welding Wire, 72Ni - 3.0Mn - 20Cr - 2.5Cb(Nb) (Inconel® FM82)

<div class="section abstract"> <div class="htmlview paragraph">This specification covers a corrosion- and heat-resistant nickel alloy in the form of welding wire.</div></div>
null null, AMS F Corrosion and Heat Resistant Alloys Committee   +1 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Steel, Corrosion-Resistant, Investment Castings, 13Cr (Alloy 60416), Free Machining; Hardened and Tempered

<div class="section abstract"> <div class="htmlview paragraph">This specification covers a corrosion-resistant steel in the form of investment castings.</div></div>
null null, AMS F Corrosion and Heat Resistant Alloys Committee   +1 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Resisting resistance to cancer immunotherapy [PDF]

Thoracic Cancer, 2018
Lam, Walter Sze‐Tung, Wang, Louis Zizhao, Roudi, Raheleh, Yong, Wei‐Peng, Syn, Nicholas L., Sundar, Raghav   +5 more
openaire   +2 more sources

Steel, Corrosion- and Heat-Resistant, Seamless Tubing, 9.0Mn - 20Cr - 6.5Ni - 0.28N (21-6-9 LC), Solution Heat Treated

<div class="section abstract"> <div class="htmlview paragraph">This specification covers a corrosion- and heat-resistant steel in the form of seamless tubing.</div></div>
null null, AMS F Corrosion and Heat Resistant Alloys Committee   +1 more
core   +1 more source

Development and characterization of western corn rootworm (Diabrotica virgifera virgifera LeConte) resistant to non-Cry insecticidal proteins Mpp75Aa1.1 and Vpb4Da2. [PDF]

PLoS One
Moar W, Khajuria C, Miller K, Pleau M, Werner B, Price P, Fridley J, Yin Y, Willse A, Tyre AJ, Head G.   +10 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Trend-resistant design of experiments under budget constraints. [PDF]

When experiments are to be performed in a time sequence, the observed responses are affected by a time trend. The construction of trend-resistant run orders is extensively described in the literature.
Tack, Lieven, Vandebroek, Martina
core