Results 141 to 150 of about 3,559,343 (361)
Resistant outlier rules and the non-Gaussian case [PDF]
The techniques of exploratory data analysis include a resistant rule, based on a linear combination of quartiles, for identification of outliers. This paper shows that the substitution of the quartiles with the median leads to a better performance in the
Carling, Kenneth
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The Efficacy of the Crude Root Bark Extracts of Erythrina Abyssinica on Rifampicin Resistant Mycobacterium Tuberculosis. [PDF]
, 2011 Tuberculosis (TB) is one of the leading causes of morbidity and mortality with a global mortality rate at two million deaths per year while one third of the world's population is infected with the TB bacillus.
Orodho, J.A. +17 more
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Recalcitrant Pyoderma Gangrenosum: Clinical Burden and Unmet Needs
Clinical, Cosmetic and Investigational Dermatology, 2023 Sarah L Becker,1,* Rose Velasco,2,* Alex G Ortega-Loayza1 1Department of Dermatology, Oregon Health & Science University, Portland, OR, USA; 2University of Illinois College of Medicine, Chicago, IL, USA*These authors contributed equally to ...
Becker SL, Velasco R, Ortega-Loayza AG
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2003 Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and ...
Sonia H. Montenegro +22 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Structural analysis of resistant polymers in extant algae and ancient sediments
, 2000 Algaenans are non-hydrolysable insoluble aliphatic biopolymeric materials present in the cell walls of some green microalgae. In these cell walls it serves a protecting role against microbial attack and/or desiccation.
Organic geochemistry & molecular biogeology +5 more
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