Results 121 to 130 of about 2,503,389 (311)
, 2021 Background: Multi-drug resistant tuberculosis impairing the effectiveness of standard treatments may contribute to increased mortality. High failure and relapse rates are recorded when standard regimens are used for multi-drug resistant ...
Karagoz, Turan +4 more
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FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Infection and Drug Resistance, 2020 Pei Li, Yang Yang, Li Ding, Xiaogang Xu, Dongfang Lin Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Dongfang Lin Tel/ Fax +86-21-52888193Email lindongfang@fudan.edu.cnPurpose: The ...
Li P, Yang Y, Ding L, Xu X, Lin D
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Drug-resistant Tuberculosis [PDF]
Type: BacteriaAlso known as: TB, multidrug-resistant TB (MDR TB), or extensively drug-resistant TB (XDR TB), Mycobacterium tuberculosis (M. tuberculosis)About: TB is caused by the bacteria M. tuberculosis, and is among the most common infectious diseases
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Resistant outlier rules and the non-Gaussian case [PDF]
The techniques of exploratory data analysis include a resistant rule, based on a linear combination of quartiles, for identification of outliers. This paper shows that the substitution of the quartiles with the median leads to a better performance in the
Carling, Kenneth
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Steel, Corrosion- and Heat-Resistant, Welding Wire, 12.5Cr (SAE 410)
<div class="section abstract"> <div class="htmlview paragraph">This specification covers a corrosion- and heat-resistant steel in the form of welding wire.</div></div>
null null +1 more
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source