Results 111 to 120 of about 3,559,343 (361)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Combined local and systemic bleomycin administration in electrochemotherapy to reduce the number of treatment sessions

Radiology and Oncology, 2016
Electrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold in the treated area with an objective response rate of around 80%. Despite its high response rate, there are still
Maglietti Felipe, Tellado Matias, Olaiz Nahuel, Michinski Sebastian, Marshall Guillermo   +4 more
doaj   +1 more source

The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer

Nature, 2012
Characterization of the prostate cancer transcriptome and genome has identified chromosomal rearrangements and copy number gains and losses, including ETS gene family fusions, PTEN loss and androgen receptor (AR) amplification, which drive prostate ...
C. Grasso, Yi-Mi Wu, D. Robinson, Xuhong Cao, S. Dhanasekaran, Amjad P. Khan, M. Quist, Xiaojun Jing, R. Lonigro, J. Brenner, I. Asangani, Bushra Ateeq, S. Chun, J. Siddiqui, L. Sam, Matt Anstett, R. Mehra, John R. Prensner, N. Palanisamy, Gregory A. Ryslik, Fabio Vandin, Benjamin J. Raphael, L. Kunju, D. Rhodes, K. Pienta, A. Chinnaiyan, S. Tomlins   +26 more
semanticscholar   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Resisting Bacterial Drug Resistance [PDF]

Chemistry & Biology, 2003
In this issue of Chemistry & Biology, Wright and colleagues report an elegant method for inhibiting enzymes critical for rendering bacteria drug resistant. By using cationic peptides as inhibitors, the authors have exploited two antibacterial mechanisms, making it doubly difficult for microbial retaliation.
openaire   +2 more sources

The transmission dynamics of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in hospital wards [PDF]

This thesis presents a study of the transmission dynamics of nosocomial pathogens in hospital wards, with particular reference to methicillinresistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).
Cooper, Ben
core  

Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy [PDF]

, 2009
Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer.
Pavlakis, Nick, Ross Davey, Davey, Ross, Nick Pavlakis, Britta Stordal, Stordal, Britta   +5 more
core   +1 more source

Effects of replacing soybean meal with enzymolysis-fermentation compound protein feed on growth performance, apparent digestibility of nutrients, carcass traits, and meat quality in growing-finishing pigs

Journal of Animal Science and Biotechnology
Background Addressing the shortage of high-quality protein resources, this study was conducted to investigate the effects of replacing soybean meal (SBM) with different levels of enzymolysis-fermentation compound protein feed (EFCP) in the diets of ...
Yu Cheng, Jun He, Ping Zheng, Jie Yu, Junning Pu, Zhiqing Huang, Xiangbing Mao, Yuheng Luo, Junqiu Luo, Hui Yan, Aimin Wu, Bing Yu, Daiwen Chen   +12 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Resistance and cross‐resistance to abacavir [PDF]

HIV Medicine, 2001
Background Abacavir (ABC) is a potent nucleoside reverse transcriptase inhibitor (NRTI) used in multi‐drug antiretroviral regimens and in combination with other NRTIs, protease and/or non‐nucleoside reverse transcriptase inhibitors (NNRTIs) in both treatment naive and treatment experienced patients.Patterns of resistance Resistance to ABC has been ...
openaire   +2 more sources