Results 101 to 110 of about 2,503,389 (311)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Molecular epidemiology of antimicrobial-resistant commensal Escherichia coli strains in a cohort of newborn calves [PDF]

, 2005
Pulsed-field gel electrophoresis (PFGE) was used to investigate the dissemination and diversity of ampicillin-resistant (Amp(r)) and nalidixic acid-resistant (Nal(r)) commensal Escherichia coli strains in a cohort of 48 newborn calves.
Gunn, GJ, Woolhouse, Mark E J; id_orcid, Turner, EJ, Low, J Chris, Low, JC, Yates, CM, Amyes, Sebastian, Davies, Sarah E, Woolhouse, MEJ, Davies, SE, Hoyle, Deborah, Hoyle, DV, Chase-Topping, Margo E, Amyes, SGB, Yates, Catherine M, Chase-Topping, M, Turner, Esther J, Gunn, George J.   +17 more
core  

A clinical study of ligamentoaxis using an external fixator, modified frame in the management of a neglected, relapsed, resistant older congenital Talipes Equino varus child

Medical Journal of Dr. D.Y. Patil University, 2013
Background: In an older, relapsed, recurrent, resistant Congenital Talipes Equino Varus (CTEV) child with previous surgical scar, soft tissue release alone is often not sufficient for full correction, particularly at above 2 years of age. Here controlled,
Ajit Shinde, Suhas Kamble, Smit Shah, Raviraj Shinde   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Screening strategies in surveillance and control of methicillin-resistant Staphylococcus aureus (MRSA) [PDF]

, 2006
With reports of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) continuing to increase and therapeutic options decrease, infection control methods are of increasing importance.
Jenkins, D. R., Robotham, Julie, Medley, Graham   +2 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2:protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension [PDF]

, 2015
INTRODUCTION: Resistant hypertension is inadequately controlled blood pressure (BP) despite treatment with at least three BP-lowering drugs. A popular hypothesis is that resistant hypertension is due to excessive Na(+)-retention, and that 'further ...
Williams, B, Caulfield, M, MacDonald, TM, Cruickshank, JK, MacDonald, Thomas M, Ford, I, Morant, S, Sever, Peter, Webb, David J, Caulfield, Mark, Brown, MJ, McInnes, G, Salsbury, J, Cruickshank, J Kennedy, Williams, Bryan, MacDonald, Thomas M., McInnes, Gordon, Salsbury, Jackie, Morant, Steve, Ford, Ian, Webb, DJ, Brown, Morris J., Cruickshank, J. Kennedy, Webb, David J., Brown, Morris, Sever, P   +25 more
core   +2 more sources

Efeito do herbicida chlorimuron-ethyl em biótipos resistente e suscetível de Euphorbia heterophylla Effect of chlorimuron-ethyl on resistant and susceptible Euphorbia heterophylla Biotypes

Planta Daninha, 2008
O objetivo deste estudo foi verificar os efeitos do chlorimuron-ethyl, inibidor da enzima acetolactato sintase (ALS), no crescimento foliar (largura e comprimento) e em altura de plantas de Euphorbia heterophylla suscetíveis e resistentes aos herbicidas ...
J.R. Aarestrup, D. Karam, G.W. Fernandes, E.J.A. Corrêa   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Resistance in the environment [PDF]

Journal of Antimicrobial Chemotherapy, 2004
Antibiotics, disinfectants and bacteria resistant to them have been detected in environmental compartments such as waste water, surface water, ground water, sediments and soils. Antibiotics are released into the environment after their use in medicine, veterinary medicine and their employment as growth promoters in animal husbandry, fish farming and ...
openaire   +2 more sources