Results 81 to 90 of about 3,559,343 (361)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2:protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension [PDF]

, 2015
INTRODUCTION: Resistant hypertension is inadequately controlled blood pressure (BP) despite treatment with at least three BP-lowering drugs. A popular hypothesis is that resistant hypertension is due to excessive Na(+)-retention, and that 'further ...
Williams, B, Caulfield, M, MacDonald, TM, Cruickshank, JK, MacDonald, Thomas M, Ford, I, Morant, S, Sever, Peter, Webb, David J, Caulfield, Mark, Brown, MJ, McInnes, G, Salsbury, J, Cruickshank, J Kennedy, Williams, Bryan, MacDonald, Thomas M., McInnes, Gordon, Salsbury, Jackie, Morant, Steve, Ford, Ian, Webb, DJ, Brown, Morris J., Cruickshank, J. Kennedy, Webb, David J., Brown, Morris, Sever, P   +25 more
core   +1 more source

Effects of dietary cinnamaldehyde supplementation in the perinatal period on reproductive performance, milk composition, redox status and gut microbiota of sows

Animal Nutrition
Improving sow health during the perinatal period is crucial for reproductive performance. Cinnamaldehyde (CA), a naturally occurring compound, is known for its anti-inflammatory, antioxidant, and gut microbiota-modulating properties. This study evaluated
Junqi Jin, Shiya Liu, Xie Peng, Changqin Wang, Qiang Zhou, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Yong Zhuo, Hua Zhao, De Wu, Lianqiang Che   +12 more
doaj   +1 more source

In vitro and in vivo Antibacterial Activity of Linezolid Plus Fosfomycin Against Staphylococcus aureus with Resistance to One Drug

Infection and Drug Resistance, 2021
Na Xie,1 Lifang Jiang,1 Mingtao Chen,1 Guijun Zhang,1 Yanyan Liu,2 Jiabin Li,2 Xiaohui Huang1 1Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Department of ...
Xie N, Jiang L, Chen M, Zhang G, Liu Y, Li J, Huang X   +6 more
doaj  

Interactive Effects of Grafting Techniques and Scion-Rootstocks Combinations on Vegetative Growth, Yield and Quality of Cucumber (Cucumis sativus L.)

Agronomy, 2019
The density of herbaceous crops creates a suitable environment to produce pathogens in the soil that intensify the attack of pathogens traditionally controlled by disinfectant, which are mostly prohibited and unlisted because of their toxicity.
Rana Shahzad Noor, Zhi Wang, Muhammad Umair, Muhammad Yaseen, Muhammad Ameen, Shoaib-Ur Rehman, Muzammil Usman Khan, Muhammad Imran, Waqar Ahmed, Yong Sun   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effects of nicotinamide riboside supplementation during late gestation and lactation on sow performance, milk metabolome, and gut microbiome

Journal of Animal Science and Biotechnology
Background Nicotinamide riboside (NR) supplementation has been demonstrated efficacy in enhancing female reproductive outcomes, but its regulatory role in sow performance and gut microbiome remains undefined.
Long Huang, Xiaohan Yang, Chenglin Pan, Wei Zhang, Yingjie Li, Ruilan Zhang, Hua Li, Ying Li, Yong Zhuo, Xuemei Jiang, Lianqiang Che, Yan Lin, Shengyu Xu, Zhengfeng Fang, Bin Feng, De Wu, Lun Hua   +16 more
doaj   +1 more source

Antimicrobial Susceptibility of Udder Pathogens Isolated from Dairy Herds in the West Littoral Region of Uruguay

Acta Veterinaria Scandinavica, 2002
A total of 522 strains belonging to streptococci, enterococci and staphylococci isolated from sub-clinical and clinical cases of bovine mastitis from the west littoral region of Uruguay were analysed for their susceptibility to several antimicrobial ...
Franklin A, Concha C, Gianneechini RE
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Bedaquiline, pretomanid and linezolid for treatment of extensively drug resistant, intolerant or non-responsive multidrug resistant pulmonary tuberculosis

New England Journal of Medicine, 2020
Background Patients with extensively drug resistant tuberculosis (TB) have limited treatment options with historically poor outcomes. We investigated treatment with 3 oral drugs, bedaquiline (B), pretomanid (Pa) and linezolid (L), (B-Pa-L), with TB ...
F. Conradie, A. Diacon, N. Ngubane, P. Howell, D. Everitt, A. Crook, C. Mendel, E. Egizi, Joanna Moreira, J. Timm, T. McHugh, G. Wills, A. Bateson, R. Hunt, C. van Niekerk, Mengchun Li, M. Olugbosi, M. Spigelman   +17 more
semanticscholar   +1 more source