Results 81 to 90 of about 2,503,389 (311)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Resistance and cross‐resistance to abacavir [PDF]

HIV Medicine, 2001
Background Abacavir (ABC) is a potent nucleoside reverse transcriptase inhibitor (NRTI) used in multi‐drug antiretroviral regimens and in combination with other NRTIs, protease and/or non‐nucleoside reverse transcriptase inhibitors (NNRTIs) in both treatment naive and treatment experienced patients.Patterns of resistance Resistance to ABC has been ...
openaire   +2 more sources

The transmission dynamics of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in hospital wards [PDF]

This thesis presents a study of the transmission dynamics of nosocomial pathogens in hospital wards, with particular reference to methicillinresistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).
Cooper, Ben
core  

The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis. [PDF]

, 2019
The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was published in 2017, which comprehensively reviewed and provided recommendations on various aspects of the disease.
Dowdy, David, Nuermberger, Eric, Chang, Kwok Chiu, Migliori, G.B., Furin, Jennifer, Limberis, Jason, Menzies, Dick, McIlleron, Helen, Jindani, Amina, Jaramillo, Ernesto, McNerney, Ruth, Nardell, Edward A., Dooley, Kelly E., Schaaf, H. Simon, Barry, Clifton E., Van Rie, Annelies, Ndjeka, Norbert, Keshavjee, Salmaan, Rodrigues, Camilla, Low, Marcus, Lange, Christoph, Padayatchi, Nesri, Nahid, Payam, Nunn, Andrew, Sirgel, Frik A., Warren, Robin M., Udwadia, Zarir F., Lessem, Erica, Maartens, Gary, Horsburgh, C. Robert, Esmail, Aliasgar, Clark, Taane G., Murray, Megan, Seddon, James A., Pasipanodya, Jotam G., Gumbo, Tawanda, Niemann, Stefan, Dheda, Keertan, Churchyard, Gavin J., London, Leslie, Theron, Grant, Fourie, Bernard, Fennelly, Kevin P., Hesseling, Anneke C., Murray, M, Warren, RM, Furin, J, Dooley, KE, Dheda, K, Nardell, EA, Maartens, G, Gumbo, T, Lancet Respiratory Medicine drug-resistant tuberculosis Commissi   +52 more
core   +1 more source

Cyclone Resistant Housing Project information bulletin

, 1992
Project ...
Cyclone Resistant Housing (Caribbean) Project
core   +1 more source

Tailoring microstructure and wear resistance of Cr–Mo alloy steel: The synergistic effects of squeeze casting and melt degassing treatment

Journal of Materials Research and Technology
The medium-carbon low-alloy Cr–Mo steel liners with ultra-larger size of 768 mm × 466 mm × 140 mm were produced by squeeze casting (SC) and the traditional sand gravity casting (GC) process, and the effect of degassing treatment before squeeze casting ...
Sai Liu, Yongzhe Wang, Dahai Zeng, Huiting Zheng, Zongqing Bo, Wei Li   +5 more
doaj   +1 more source

Performance, Antimicrobial Effect and Carcass Parameters of Finisher Broilers Given Xylopia aethiopica Dried Fruits (Grains of Selim) as Additive

Agricultura Tropica et Subtropica, 2014
The effect of graded levels of grains of selim on the performance, gut microbial population and carcass characteristics of finisher broilers was investigated. Two hundred and four (204) 28 days old broiler chicks (Marshal breed) were randomly allotted to
Isikwenu Jonathan Ogagaoghene, Udeh Ifeanyi, Izuchukwu Oshai Bernard, Ogheneremu Kekeke Theresa   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source