Results 91 to 100 of about 3,559,343 (361)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda. [PDF]

, 2007
BACKGROUND: Resistance to anti-tuberculosis drugs is a serious public health problem. Multi-drug resistant tuberculosis (MDR-TB), defined as resistance to at least rifampicin and isoniazid, has been reported in all regions of the world.
Traore, Hamidou, Hamidou Traore, Jones-Lopez, Edward C, McNerney, Ruth, Eisenach Kathleen D, Joloba, Moses L, Jones-Lopez Edward C, Roy D Mugerwa, Smith, Peter G, Mugerwa, Roy D, Ogwang Sam, Smith Peter G, Moses L Joloba, Mallard, Kim, Kathleen D Eisenach, Jerrold J Ellner, Ellner, Jerrold J, Eisenach, Kathleen D, Ogwang, Sam, Mugerwa Roy D, Kayes, Susan, McNerney Ruth, Edward C Jones-Lopez, Kalpana Narayan, Ruth McNerney, Peter G Smith, Sam Ogwang, Susan Kayes, Joloba Moses L, Narayan, Kalpana, Francis Mumbowa, Narayan Kalpana, Ellner Jerrold J, Mumbowa, Francis, Kayes Susan, Kim Mallard, Traore Hamidou, Mumbowa Francis, Mallard Kim   +38 more
core   +1 more source

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria.

Cell Host and Microbe, 2019
Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in Western medicine. This stems from the rise in frequency of multi-drug-resistant bacterial infections in humans.
K. Kortright, B. Chan, J. Koff, P. Turner   +3 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stab resistant body armour [PDF]

, 2000
There is now a widely accepted need for stab resistant body armour for the police in the UK. However, very little research has been done on knife resistant systems and the penetration mechanics of sharp projectiles are poorly understood.
Horsfall, Ian
core  

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H   +55 more
core   +1 more source

Darolutamide in Nonmetastatic, Castration‐Resistant Prostate Cancer

New England Journal of Medicine, 2019
BACKGROUND Darolutamide is a structurally unique androgen‐receptor antagonist that is under development for the treatment of prostate cancer. We evaluated the efficacy of darolutamide for delaying metastasis and death in men with nonmetastatic ...
K. Fizazi, N. Shore, T. Tammela, A. Ulys, E. Vjaters, S. Polyakov, M. Jievaltas, M. Luz, B. Alekseev, I. Kuss, C. Kappeler, A. Snapir, T. Sarapohja, Matthew R. Smith   +13 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Resistant Hypertension or Resistant Prescribing? [PDF]

Hypertension, 2011
See related article, pp 1008–1013 The term “resistant hypertension” (RH) evokes a myriad of clinical descriptions, nearly all of which implicitly ascribe origins of the problem to characteristics inherent within the patient or maleficent qualities of the disease itself.
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source