Results 131 to 140 of about 3,559,343 (361)

Impact of target site distribution for Type I restriction enzymes on the evolution of methicillin-resistant Staphylococcus aureus (MRSA) populations. [PDF]

, 2013
A limited number of Methicillin-resistant Staphylococcus aureus (MRSA) clones are responsible for MRSA infections worldwide, and those of different lineages carry unique Type I restriction-modification (RM) variants.
Dryden, David T. F., White, John H., Stephanou, AS, Cooper, Laurie P., Cooper, LP, Houston, PJ, Lindsay, JA, Chen, K, Dryden, DT, Roberts, Gareth A., Lindsay, Jodi A., Chen, Kai, Roberts, GA, White, JH, Stephanou, Augoustinos S., Houston, Patrick J.   +15 more
core   +1 more source

Resistant Hypertension: Detection, Evaluation, and Management

HYPERTENSION, 2018
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin ...
R. Carey, D. Calhoun, G. Bakris, R. Brook, S. Daugherty, C. Dennison-Himmelfarb, B. Egan, J. Flack, S. Gidding, E. Judd, D. Lackland, Cheryl L. Laffer, C. Newton‐Cheh, Steven M. Smith, S. Taler, S. Textor, T. Turan, W. White   +17 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats: a case-control study. [PDF]

, 2010
Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats were investigated in an unmatched case-control study. A total of 197 animals from 150 veterinary practices across the United Kingdom was enrolled, including ...
Pfeiffer, Dirk Udo, Mick Rich, Soares Magalhães, RJ, Soares Magalhaes, Ricardo Jorge, Lindsay, Jodi, Lindsay, J, Lloyd, David Hugh, Larry Roberts, Loeffler, A, St George's, Lindsay, J A, Rich, M, Queensland, Australia, Pfeiffer, D U, Loeffler, Anette, Smith, H, Teringie SA, Australia, Smith, Heather, Soares-Magalhaes, R J, Lloyd, D H, Lloyd, DH, Roberts, Larry, Ricardo Jorge Soares Magalhães, Heather Smith, Rich, Mick, Anette Loeffler, Jodi Lindsay, David Hugh Lloyd, Dirk Udo Pfeiffer, Pfeiffer, DU, IDEXX Labs, Roberts, L   +31 more
core   +1 more source

Efeito do herbicida chlorimuron-ethyl em biótipos resistente e suscetível de Euphorbia heterophylla Effect of chlorimuron-ethyl on resistant and susceptible Euphorbia heterophylla Biotypes

Planta Daninha, 2008
O objetivo deste estudo foi verificar os efeitos do chlorimuron-ethyl, inibidor da enzima acetolactato sintase (ALS), no crescimento foliar (largura e comprimento) e em altura de plantas de Euphorbia heterophylla suscetíveis e resistentes aos herbicidas ...
J.R. Aarestrup, D. Karam, G.W. Fernandes, E.J.A. Corrêa   +3 more
doaj   +1 more source

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

Cancer Cell, 2018
SUMMARY We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone receptor-positive tumors, with detailed clinical information and treatment outcomes.
P. Razavi, Matthew T. Chang, Guotai Xu, C. Bandlamudi, D. Ross, N. Vasan, Yanyan Cai, C. Bielski, M. Donoghue, P. Jonsson, A. Penson, R. Shen, F. Pareja, R. Kundra, S. Middha, M. Cheng, A. Zehir, Cyriac Kandoth, Ruchi Patel, K. Huberman, L. Smyth, K. Jhaveri, S. Modi, T. Traina, C. Dang, Wen Zhang, B. Weigelt, Bob T. Li, M. Ladanyi, D. Hyman, N. Schultz, M. Robson, C. Hudis, E. Brogi, A. Viale, L. Norton, M. Dickler, M. Berger, C. Iacobuzio-Donahue, S. Chandarlapaty, M. Scaltriti, J. Reis-Filho, D. Solit, B. Taylor, J. Baselga   +44 more
semanticscholar   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Universal screening for meticillin-resistant Staphylococcus aureus : interim results from the NHS Scotland pathfinder project

, 2009
Following recommendations from a Health Technology Assessment (HTA), a prospective cohort study of meticillin-resistant Staphylococcus aureus (MRSA) screening of all admissions (N = 29 690) to six acute hospitals in three regions in Scotland indicated ...
Masterton, R., Allardice, G., , Scottish Government Health Directorate (Funder), Reilly, Jacqui; id_orcid, Williams, C., Gould, I. M., Smith, A., Stewart, S., Gould, I.M., Christie, P., Scottish Government Health Directorate (Funder), Reilly, J.S.   +11 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source