Results 81 to 90 of about 6,979 (181)

Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review

Frontiers in Immunology
Sepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death.
Shujun Sun, Shujun Sun, Shujun Sun, Shujun Sun, Dong Yang, Dong Yang, Dong Yang, Jing Lv, Jing Lv, Jing Lv, Haifa Xia, Haifa Xia, Haifa Xia, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao   +22 more
doaj   +1 more source

Efficacy of a Novel Pleiotropic MMP-Inhibitor, CMC2.24, in a Long-Term Diabetes Rat Model with Severe Hyperglycemia-Induced Oral Bone Loss

Journal of Inflammation Research, 2023
Heta Dinesh Bhatt,1 Lorne M Golub,1 Hsi-Ming Lee,1 Jihwan Kim,2 Thomas Zimmerman,3 Jie Deng,4 Houlin Hong,5 Francis Johnson,6 Ying Gu7 1Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA ...
Bhatt HD, Golub LM, Lee HM, Kim J, Zimmerman T, Deng J, Hong H, Johnson F, Gu Y   +8 more
doaj  

Inflammation and pro-resolution inflammation after hepatobiliary surgery

World Journal of Surgical Oncology, 2017
Background The magnitude of the perioperative inflammatory response plays a role in surgical outcomes. However, few studies have explored the mechanisms of the resolution of inflammation in the context of surgery. Here, we described the temporal kinetics
Juan P. Cata, Jose F. Velasquez, Maria F. Ramirez, Jean-Nicolas Vauthey, Vijaya Gottumukkala, Claudius Conrad, Bradford J. Kim, Thomas Aloia   +7 more
doaj   +1 more source

Expression data on liver metabolic pathway genes and proteins

Data in Brief, 2016
Here, we present the expression data on various metabolic pathways of liver with special emphasize on lipid and carbohydrate metabolism and long chain polyunsaturated fatty acid (PUFA) synthesis, both at gene and protein levels. The data were obtained to
Mooli Raja Gopal Reddy, Chodisetti Pavan Kumar, Malleswarapu Mahesh, Manchiryala Sravan Kumar, Shanmugam M. Jeyakumar   +4 more
doaj   +1 more source

Resolvin D1 protects periodontal ligament

American Journal of Physiology-Cell Physiology, 2013
Resolution agonists are endogenous mediators that drive inflammation to homeostasis. We earlier demonstrated in vivo activity of resolvins and lipoxins on regenerative periodontal wound healing. The goal of this study was to determine the impact of resolvin D1 (RvD1) on the function of human periodontal ligament (PDL) fibroblasts, which are critical ...
Manal, Mustafa, Ahmed, Zarrough, Anne Isine, Bolstad, Henning, Lygre, Kamal, Mustafa, Hatice, Hasturk, Charles, Serhan, Alpdogan, Kantarci, Thomas E, Van Dyke   +8 more
openaire   +3 more sources

The potential of exogenous specialized pro-resolving mediators in protecting against sepsis-associated lung injury: a review

Frontiers in Pharmacology
Sepsis-associated lung injury (SALI) is a critical condition with high mortality. Current therapies are limited, necessitating novel approaches. This review highlights the potential of exogenous Specialized Pro-resolving Mediators (SPMs), including ...
Jiwei Shen, Jiwei Shen, Jiwei Shen, Huiqin Shen, Huiqin Shen, Huiqin Shen, Shujun Sun, Shujun Sun, Shujun Sun, Shiwen Fan, Shiwen Fan, Shiwen Fan, Tianhao Zhang, Tianhao Zhang, Tianhao Zhang, Guobin Song, Guobin Song, Guobin Song, Ning An, Ning An, Ning An, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao   +26 more
doaj   +1 more source

Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints

Journal of Nutrition and Metabolism, 2016
Aims. In this study a streptozotocin induced type 1 diabetes mouse model was used to assess the effectiveness of salsalate, menhaden oil, the combination of salsalate and menhaden oil, or resolvin D1 on neuropathic endpoints.
Matthew S. Yorek, Lawrence J. Coppey, Hanna Shevalye, Alexander Obrosov, Randy H. Kardon, Mark A. Yorek   +5 more
doaj   +1 more source

Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin

Beilstein Journal of Organic Chemistry, 2013
The total synthesis of the endogenous inflammation resolving eicosanoid resolvin D2 (1) is described. The key steps involved a Wittig reaction between aldehyde 5 and the ylide derived from phosphonium salt 6 to give enyne 17 and condensation of the same ...
John Li, May May Leong, Alastair Stewart, Mark A. Rizzacasa   +3 more
doaj   +1 more source

Novel Biphasic Role of Resolvin D1 on Expression of Cyclooxygenase-2 in Lipopolysaccharide-Stimulated Lung Fibroblasts Is Partly through PI3K/AKT and ERK2 Pathways

Mediators of Inflammation, 2013
Fibroblasts, far frombeing merely bystander cells, are known to play a specific role in inflammation resolution after an acute injury. As the endogenous “braking signal,” resolvins possess potent anti-inflammatory and proresolution actions.
Derong Wu, Shengxing Zheng, Wenjuan Li, Li Yang, Yongjian Liu, Xia Zheng, Yi Yang, Liangmin Yang, Qian Wang, Fang Gao Smith, Shengwei Jin   +10 more
doaj   +1 more source

Advances in the Chemistry and Biology of Specialised Pro-Resolving Mediators (SPMs)

Molecules
This review article assembles key recent advances in the synthetic chemistry and biology of specialised pro-resolving mediators (SPMs). The major medicinal chemistry developments in the design, synthesis and biological evaluation of synthetic SPM ...
Lucy Byrne, Patrick J. Guiry
doaj   +1 more source