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The Utilisation of Resolvins in Medicine and Tissue Engineering.

Acta Biomaterialia, 2021
Recent advances in the field of regenerative medicine and biomaterial science have highlighted the importance of controlling immune cell phenotypes at the biomaterial interface.
Fanny Blaudez   +3 more
semanticscholar   +1 more source

Stereocontrolled total synthesis of Resolvin D4 and 17(R)-Resolvin D4

Organic & Biomolecular Chemistry, 2023
We describe the stereocontrolled synthesis of Resolvin D4 and 17(R)-Resolvin D4. These molecules possess protective activities in resolving inflammation.
Robert Nshimiyimana   +3 more
openaire   +2 more sources

Fatty acids and their metabolites (resolvins) are altered in women with gestational diabetes mellitus (GDM).

Food & Function
The maternal fatty acid status plays a key role in influencing pregnancy outcomes. Omega-3 fatty acids are the precursors for E-series (RvE) and D-series resolvins (RvD) and possess anti-inflammatory properties.
Nikita Joshi   +9 more
semanticscholar   +1 more source

Total Synthesis of Resolvin D5

The Journal of Organic Chemistry, 2017
Resolvin D5 (RvD5) is a metabolite of docosahexanoic acid with anti-inflammatory activity that has not yet been thoroughly investigated because of its low biological availability. A synthetic route to optically active RvD5 was developed by assembling the C1-C10 aldehyde, C11-C13 phosphonium salt, and C14-C22 aldehyde building blocks.
Narihito Ogawa   +4 more
openaire   +2 more sources

Stereocontrolled synthesis of resolvin D1

Organic & Biomolecular Chemistry, 2019
Four pieces were assembled by the reactions indicated, and the dehydro precursor was semi-hydrogenated to give resolvin D1 (RvD1).
Masao Morita   +2 more
openaire   +2 more sources

Stereocontrolled Synthesis of Resolvin D4

The Journal of Organic Chemistry, 2018
The stereoselective synthesis of resolvin D4 (RvD4) was achieved using the Wittig reaction of the C1-C10 dienal with the known C11-C22 phosphonium salt. The ( S, E)-enantiomer ( S)-10, corresponding to the C1-C8 part, was synthesized in 95% ee by the asymmetric transfer hydrogenation reaction of the corresponding acetylenic ketone followed by Red-Al ...
Masao Morita, Yuichi Kobayashi
openaire   +2 more sources

Clinical influence of calcium hydroxide and N-acetylcysteine on the levels of resolvins E1 and D2 in apical periodontitis.

International Endodontic Journal, 2020
AIM To investigate the presence of resolvins E1 (RvE1) and D2 (RvD2) in teeth with primary endodontic infection and apical periodontitis, and to assess the influence of calcium hydroxide medication [Ca(OH)2 ], in association with 2% chlorhexidine gel (2%
B. Corazza   +7 more
semanticscholar   +1 more source

Immuno-Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega-3 Fatty Acids in Metabolic Syndrome.

Molecular Nutrition & Food Research, 2019
Omega-3 fatty acid consumption has been suggested to be beneficial for the prevention of type 2 diabetes mellitus (T2DM). Its effects have been attributed to anti-inflammatory activity, with the inhibition of arachidonic acid metabolism playing a central
Y. Kwon
semanticscholar   +1 more source

Resolvin’ inflammation

Science Translational Medicine, 2016
Plaque progression was halted by inducing inflammation resolution in the blood vessel walls of a mouse model of atherosclerosis with the preresolving lipid mediator RvD1.
openaire   +1 more source

Lipoxins, Resolvins, and the Resolution of Inflammation

2016
Resolution of acute inflammation is an active process, where endogenous specialized pro-resolving mediators (SPM), derived from polyunsaturated fatty acids via lipoxygenase (LO)-driven biochemical pathways, have pivotal roles in “turning off” pro-inflammatory signals, prompting timely resolution.
RECCHIUTI, ANTONIO   +3 more
openaire   +1 more source

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