Results 41 to 50 of about 106,992 (298)

Hydrodynamic Investigation on a Land-Fixed OWC Wave Energy Device under Irregular Waves

Applied Sciences, 2022
The hydrodynamic response of a land-based oscillating water column (OWC) wave energy converter under various irregular wave conditions is investigated numerically. Based on the potential flow theory, a two-dimensional fully nonlinear numerical wave flume
Zhimin Zhou, Song Ke, Rongquan Wang, Robert Mayon, Dezhi Ning   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Gas Motion Study of Lya Emitters at z~2 Using UV and Optical Spectral Lines

, 2013
We present the results of Magellan/MMIRS and Keck/NIRSPEC spectroscopy for five Lya emitters (LAEs) at z=2.2 for which high-resolution FUV spectra from Magellan/MagE are available. We detect nebular emission lines including Ha on the individual basis and
Becker, Blanc, Bond, Bond, Brocklehurst, Calzetti, Cardamone, Cowie, Daddi, Dijkstra, Dunkley, Elvis, Erb, Erb, Finkelstein, Finkelstein, Finkelstein, Guaita, Harrington, Heckman, Kashikawa, Kashikawa, Kazuhiro Shimasaku, Kewley, Kimihiko Nakajima, Komatsu, Kornei, Kornei, Kunth, Larson, Luo, Martin, Masami Ouchi, Matsuda, McCracken, McLinden, Michael Rauch, Milvang-Jensen, Murray, Nakajima, Nakajima, Ono, Ono, Ota, Ouchi, Peng, Pentericci, Pettini, Rauch, Reddy, Sadanori Okamura, Schenker, Schinnerer, Shapley, Shapley, Sharma, Steidel, Steidel, Takuya Hashimoto, Tremonti, Yang, Yang, Yoshiaki Ono, Yuma   +63 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Modeling the Stiffening Behavior of Sand Subjected to Dynamic Loading

Geosciences
In geotechnical engineering, dynamic soil models are used to predict soil behavior under different loading conditions. This is crucial for many dynamic geotechnical problems related to earthquakes, train loading and machine foundation design. Researchers
Majd Ahmad, Richard Ray
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

ML-Driven Decision Support for Dynamic Modeling of Calcareous Sands

Machine Learning and Knowledge Extraction
Dynamic characterization of calcareous (carbonate) sands is essential for performance-based design of offshore foundations, coastal reclamation, and marine infrastructure in tropical and subtropical regions.
Abdalla Y. Almarzooqi, Mohamed G. Arab, Maher Omar, Emran Alotaibi   +3 more
doaj   +1 more source

Characterizing the Effect of Water Content on Small-Strain Shear Modulus of Qiantang Silt

Journal of Marine Science and Engineering, 2021
Due to the impact of natural and artificial influence, such as waves, tides, and artificial dewatering, the small-strain shear modulus of soils may vary with the water content of soil, causing deformation of excavations and other earth structures.
Lisha Zhang, Shimin Zhang, Xin Liu, Yinsuo Sun   +3 more
doaj   +1 more source

Absorption imaging of a quasi 2D gas: a multiple scattering analysis [PDF]

, 2011
Absorption imaging with quasi-resonant laser light is a commonly used technique to probe ultra-cold atomic gases in various geometries. Here we investigate some non-trivial aspects of this method when it is applied to in situ diagnosis of a quasi two ...
Cohen-Tannoudji C, Cohen-Tannoudji C, Goetschy A, J Dalibard, Jackson J D, Javanainen J, Ketterle W, L Chomaz, L Corman, Messiah A, Morice O, Müller C A, R Desbuquois, Skipetrov S E, T Yefsah   +14 more
core   +1 more source