Results 61 to 70 of about 228,839 (261)

Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior

eLife
Millions of Americans suffering from Opioid Use Disorders face a high risk of fatal overdose due to opioid-induced respiratory depression (OIRD). Fentanyl, a powerful synthetic opioid, is a major contributor to the rising rates of overdose deaths ...
Brian C Ruyle, Sarah Masud, Rohith Kesaraju, Mubariz Tahirkheli, Juhi Modh, Caroline G Roth, Sofia Angulo-Lopera, Tania Lintz, Jessica A Higginbotham, Nicolas Massaly, Jose A Morón   +10 more
doaj   +1 more source

Anesthetic complications including two cases of postoperative respiratory depression in living liver donor surgery

Journal of Anaesthesiology Clinical Pharmacology, 2011
Background: Living liver donation is becoming a more common means to treat patients with liver failure because of a shortage of cadaveric organs and tissues.
David Beebe, Harpreet Singh, John Jochman, Paul Luikart, Ranier Gruessner, Angelica Gruessner, Kumar Belani   +6 more
doaj   +1 more source

Respiratory depression in women receiving propofol/esketamine versus propofol/fentanyl for abortion surgery or curettage: a randomized clinical trial

Annals of Medicine
Background A combination of opioids with propofol is a popular approach to non-intubated general anaesthesia; however, this method usually results in higher incidence of respiratory depression.
Cuiwen Zhang, Jiaxin Luo, Yeqing Liao, Huiyu Cao, Xiaoshan Wu, Xiaofang Huang, Hongmeng Lan, Yuliu Lin, Huihe Chen, Xuehai Guan   +9 more
doaj   +1 more source

Revisiting paravertebral muscles in European rabbits (Oryctolagus cuniculus) and European brown hares (Lepus europaeus) (Leporidae; Lagomorpha)

The Anatomical Record, EarlyView.
Abstract Domesticated European rabbits (Oryctolagus cuniculus) have long been chosen as laboratory model organisms. Despite this, there has been no definitive study of the vertebral musculature of wild rabbits. Relevant descriptions of well‐studied veterinary model mammals (such as dogs) are generally applicable, but not appropriate for a species ...
Nuttakorn Taewcharoen, Emma Sherratt, Philip Stott, Rachel Norris   +3 more
wiley   +1 more source

Antagonism of morphine-induced central respiratory depression by donepezil in the anesthetized rabbit

Biological Research, 2007
Morphine is often used in cancer pain and postoperative analgesic management but induces respiratory depression. Therefore, there is an ongoing search for drug candidates that can antagonize morphine-induced respiratory depression but have no effect on ...
MIKI TSUJITA, SHIGEKI SAKURABA, JUNYA KURIBAYASHI, YUKI HOSOKAWA, EIKI HATORI, YASUMASA OKADA, MASANORI KASHIWAGI, JUNZO TAKEDA, SHUN-ICHI KUWANA   +8 more
doaj  

Acute toxicity and sex-dependent lethality of isotonitazene in fischer 344 rats

Frontiers in Toxicology
Isotonitazene is a highly potent benzimidazole-derived synthetic opioid increasingly implicated in fatal intoxications. Despite growing forensic detection, controlled in vivo toxicity data remain limited.
Yesenia Lopez Hernandez, Horatiu Vinerean, Saurabh Aggarwal, Saurabh Aggarwal   +3 more
doaj   +1 more source

Nasal soft‐tissue anatomy of Triceratops and other horned dinosaurs

The Anatomical Record, EarlyView.
Abstract Although ceratopsid dinosaurs possess a characteristically hypertrophied narial region, soft‐tissue anatomy associated with such a skeletal structure and their biological significance remain poorly understood. The present study provides the first comprehensive hypothesis on the soft‐tissue anatomy in the ceratopsid rostrum based on the Extant ...
Seishiro Tada, Takanobu Tsuihiji, Hiroki Ishikawa, Noriyuki Wakimizu, Soichiro Kawabe, Kodai Sakane   +5 more
wiley   +1 more source

Effects of oropharyngeal neuromuscular stimulation on the volumetric enlarged and reduced tongue base in minipigs

The Anatomical Record, EarlyView.
Abstract Hypoglossal nerve or tongue protruding muscle stimulation is a current treatment option for obstructive sleep apnea. Thus, the present study analyzed 3D deformations of the volumetric enlarged and reduced tongue base upon oropharyngeal neuromuscular stimulation.
Sydney Chen, Doris Haydee Rosero Salazar, Zi‐Jun Liu   +2 more
wiley   +1 more source

Research progress on biased μ-opioid receptor agonists

徐州医科大学学报
Opioid analgesics, which primarily exert their effects through μ-opioid receptors, have long been valuable choices in pain management. However, opioid analgesics often cause various adverse reactions that are common to traditional opioids, especially ...
LI Ning, LIU Cunming
doaj   +1 more source

Different shape but the same topographical complexity—The lingual gross anatomy of the Saimaa (Pusa saimensis) and Baltic ringed seals (Pusa hispida botnica)

The Anatomical Record, EarlyView.
Abstract Despite the distinctly different shapes of their tongues, the tongue gross anatomy of Saimaa ringed seal closely resembled that of Baltic ringed seal. There were no differences in the extrinsic and intrinsic tongue muscles or their associated vascularization and innervation between Saimaa and Baltic ringed seals.
Juha Laakkonen, Heini Nihtilä
wiley   +1 more source