Results 31 to 40 of about 16,243 (160)
Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems
Small, EarlyView.Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic +4 more
wiley +1 more source
Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective
World Medical &Health Policy, EarlyView.ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To determine if routine administration of antenatal corticosteroids affects the risk of infant lower respiratory tract infection and/or childhood asthma. Design Linked population‐based cohort analysed using a regression discontinuity design, which better controls for confounding than standard observational studies.
Jennifer A. Hutcheon +8 more
wiley +1 more source
The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Aging Cell, EarlyView.Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond
Muthu Saravanan Manoharan +176 more
wiley +1 more source
Aging Cell, EarlyView.Aging of the lymph node stromal cells limits their ability to support the survival and maintenance of peripheral naive T cells. The lymph node stromal cells are critical for providing the survival and trophic signals to peripheral naïve T cells, and after the early‐life thymic involution, these secondary lymphoid organ stromal microniches are decisive ...
Sandip Ashok Sonar +6 more
wiley +1 more source
Allergy, EarlyView.A pivotal Phase III DBPC adaptive trial was conducted with PQ Grass 27600 SU. The primary endpoint EAACI‐CSMS0–6 demonstrated a highly significant, clinically meaningful improvement for PQ Grass of −0.27 points (95% CI: −0.42 to −0.12), corresponding to a relative difference of −20.3% (p = 0.0005) over placebo. Highly consistent secondary endpoints and
Stefan Zielen +100 more
wiley +1 more source
Gastrointestinal Barrier Disruption in Post‐COVID Syndrome Fatigue Patients
Allergy, EarlyView.Gastrointestinal (GI) barrier disruption in the context of SARS‐CoV‐2 infection is associated with the development of Post‐COVID Syndrome (PCS) Fatigue. Pre‐existing GI complaints may predispose to fatigue development. Monitoring GI symptoms and markers before, during, and after SARS‐CoV‐2 infection is crucial for identifying predictive clinical ...
Johanna Rohrhofer +8 more
wiley +1 more source
Patterns of Respiratory Symptoms and Asthma Diagnosis in School‐Age Children: Three Birth Cohorts
Allergy, EarlyView.We performed guided multi‐domain clustering of symptoms and triggers in school‐age children across three birth cohorts. Using 15 variables, five clusters were identified. Two clusters showed a high prevalence of asthma with persistent symptoms.
Alex Cucco +15 more
wiley +1 more source
Respiratory Syncytial Virus Vaccination Is Associated With Increased Odds of Preterm Birth
Acta Paediatrica, EarlyView.ABSTRACT Aim To analyse whether respiratory syncytial virus (RSV) vaccination during pregnancy increases the odds of preterm birth. Methods A rapid review and meta‐analysis was performed. The main outcome was the risk of preterm (gestational week less than 37) birth.
Ilari Kuitunen, Marjut Haapanen
wiley +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim The prevalence of meningitis and encephalitis of unknown aetiology in Spanish children has not been specifically documented before. The aim of this study is to describe the epidemiology and trends of these clinical conditions between 2016 and 2020.
Marina Pons‐Espinal +5 more
wiley +1 more source