Results 81 to 90 of about 2,474,096 (395)

Optimizing Fermentation Medium to Produce Cyclosporin a Using Response Surface Methodology [PDF]

, 2012
Response surface methodology (RSM) is a three factorial model which illustrates the relationship between one or more independent variables. RSM can be used to optimize the fermentation medium for the production of Cyclosporin A from the isolate ...
Sunaryanto, R. (Rofiq)
core   +4 more sources

Polynomial Regression and Response Surface Methodology: Theoretical Non-Linearity, Tutorial and Applications for Information Systems Research

Australasian Journal of Information Systems, 2019
Information systems (IS) studies regularly assume linearity of the variables and often disregard the potential non-linear theoretical interrelationships among the variables.
Darshana Sedera, Maura Atapattu
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Optimization of Electrochemiluminescence Experimental Conditions for Metoclopramide Determination Based on Response Surface Methodology

International Journal of Electrochemical Science, 2020
Based on the strongenhancement effect of metoclopramide on the electrochemiluminescencesignal of Ru(bpy)32+ on the platinum electrode, a novelmethod for the sensitive detection of metoclopramide was established.
Fuxiu Yang, Wenjuan Zhang, Baining Liu, Yizhi Ji, Youxi Zhao, Kaowen Zhou   +5 more
doaj   +1 more source

Application of response surface methodology to laser-induced breakdown spectroscopy : influences of hardware configuration [PDF]

, 2007
Response Surface Methodology (RSM) was employed to optimise LIBS analysis of single crystal silicon at atmospheric pressure and under vacuum conditions (pressure ~10-6mbar).
A.E. Hill, Bas, Belloto, Benyounis, Box, Choudhury, Chávez-Valencia, Forsberg, Garcia, Harilal, J.S. Astin, J.S. Cowpe, Kalathenos, Krajnik, Kwak, Lee, Liyana-Pathirana, Loh, Mathew, Noordin, Olabi, Onwubolu, Pan, R.D. Pilkington, Sattmann, Zurera-Cosano   +25 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Optimisation of Ultrasonic Conditions as an Advanced Extraction Technique for Recovery of Phenolic Compounds and Antioxidant Activity from Macadamia (Macadamia tetraphylla) Skin Waste

Technologies, 2015
Thousands of tons of macadamia skin waste are generated annually with very limited utilisation of this extensive by-product. The aim of this study was to develop optimal ultrasonic extraction conditions for maximized recovery of phenolic compounds and ...
Adriana Dailey, Quan V. Vuong
doaj   +1 more source

A Study on the Beech Wood Machining Parameters Optimization Using Response Surface Methodology [PDF]

, 2022
Sajjad Pakzad, Siamak Pedrammehr, Mahsa Hejazian   +2 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Optimization of the PDMS/biochar nanocomposite membranes using the response surface methodology

Science and Engineering of Composite Materials, 2018
To improve the separation performance of the polydimethylsiloxane (PDMS)/bark biochar (BB) nanocomposite membranes used for alcohol/water separation, the preparation conditions of these composite membranes were analyzed and optimized.
Lan Yongqiang, Yan Ning, Wang Weihong
doaj   +1 more source