Results 51 to 60 of about 3,686,228 (287)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Building voluntary partnerships for climate action: An exploratory study from Iceland

Cleaner and Responsible Consumption, 2021
The Paris Agreement called for voluntary cooperation between firms, NGOs, and the state, to meet global climate goals. This study examines the development of voluntary carbon projects (VCPs) in Iceland – a country aiming to be carbon neutral by 2040 ...
William Nikolakis, Gunnlaugur Guðjónsson   +1 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analysis of barriers of sustainable supply chain management in electronics industry: An interpretive structural modelling approach

Cleaner and Responsible Consumption, 2021
In the past, industries were concentrating only on the economic aspects of a business. Many organizations are now addressing the social and environment impact of their supply chain for which they are adopting sustainability in their supply chain.
Rakesh R. Menon, V. Ravi
doaj   +1 more source

ViveChachapoyas.Com: Encouragement of Sustainable and Responsible Consumption of Community Rural Tourism Through Digital Transformation

, 2022
(a) Situation faced: The Community Rural Tourism (CRT) in Chachapoyas, Peru, will not entirely take advantage until developing a viable business model, supported by the information technologies (IT) as facilitators to introduce local operators and the ...
Nestor U. Salcedo, Salcedo Zuta, Nestor Ulaf, Fátima Castillo Botetano, Castillo Botetano, Fátima   +3 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Assessment of sustainable third party reverse logistic provider using the single-valued neutrosophic Combined Compromise Solution framework

Cleaner and Responsible Consumption, 2021
Customers’ pressure, social responsibility and government regulations have motivated the enterprises to consider the Reverse Logistics (RL) in their operations.
Arunodaya Raj Mishra, Pratibha Rani
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source