Results 21 to 30 of about 409,301 (101)

sEEG‐guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode‐mediated neuromodulation

Epilepsia Open
Objectives Pivotal trials have established the effectiveness of the Responsive Neurostimulation System (RNS® System) in treating focal epilepsy. In clinical trials, depth leads were primarily used to treat mesial temporal seizure onsets while cortical ...
Sina Sadeghzadeh, David A. Purger, Priya Bhanot, Noriah Johnson, Daniel A. N. Barbosa, Yuhao Huang, Jay J. Park, Ethan Schonfeld, Matthew A. Abikenari, Bhav Jain, Joshua P. Aronson, Cornelia Drees, Tiffany L. Fisher, Jason Gerrard, Tyler E. Gray, Saadi Ghatan, Kevin Hines, Barbara C. Jobst, Ioannis Karakis, Steven G. Ojemann, Imran H. Quraishi, Ahmed M. Raslan, Michael D. Sather, Christopher T. Skidmore, Jon T. Willie, Chengyuan Wu, Ji Yeoun Yoo, Kevin D. Graber, Casey H. Halpern, Vivek P. Buch, Jonathon J. Parker   +30 more
doaj   +2 more sources

Responsive neurostimulation for treatment of pediatric refractory epilepsy: A pooled analysis of the literature

, 2023
Drug-resistant epilepsy (DRE) is a complex medical condition often requiring resective surgery and/or some form of neurostimulation. In recent years responsive neurostimulation (RNS) has shown promising results in adult DRE, however there is a paucity of
Marytery Fajardo, Bystrom, Lauren L., Levy, Adam S., Wang, Shelly, Lauren L. Bystrom, Fajardo, Marytery, Adam S. Levy, Erik C. Brown, Shelly Wang, Brown, Erik C., Wang, Kelly   +10 more
core   +1 more source

Brain‐responsive corticothalamic stimulation in the pulvinar nucleus for the treatment of regional neocortical epilepsy: A case series

Epilepsia Open, 2021
Drug‐resistant focal epilepsy with regional neocortical seizure onsets originating from the posterior quadrant can be particularly difficult to treat with resective surgery due to the overlap with eloquent cortex.
David Burdette, Emily A. Mirro, Michael Lawrence, Sanjay E. Patra   +3 more
doaj   +1 more source

Effects of anterior thalamic nuclei stimulation on hippocampal activity: Chronic recording in a patient with drug-resistant focal epilepsy

Epilepsy & Behavior Reports, 2021
Implanted neurostimulation devices are gaining traction as palliative treatment options for certain forms of drug-resistant epilepsy, but clinical utility of these devices is hindered by incomplete mechanistic understanding of their therapeutic effects ...
Alexander B. Silva, Ankit N. Khambhati, Benjamin A. Speidel, Edward F. Chang, Vikram R. Rao   +4 more
doaj   +1 more source

Brain-responsive neurostimulation for epilepsy (RNS® System)

Epilepsy Research, 2019
Controlled clinical trials in adults with medically intractable focal seizures treated with the RNS® System demonstrate that closed-loop responsive neurostimulation to the seizure focus reduces the frequency of disabling seizures, is well tolerated, and is acceptably safe.
Tara L. Skarpaas, Beata Jarosiewicz, Martha J. Morrell   +2 more
openaire   +2 more sources

Brain-responsive neurostimulation in adult-onset rasmussen's encephalitis

Epilepsy & Behavior Reports, 2021
Epilepsy associated with Rasmussen’s encephalitis (RE) is highly resistant to standard therapy and continues to present a therapeutic challenge. While epilepsy surgery remains the most effective management for patients with drug-resistant focal epilepsy ...
Anteneh M. Feyissa, Alaa S. Mohamed, William O. Tatum, Alana S. Campbell, A. Sebastian Lopez-Chiriboga   +4 more
doaj   +1 more source

Optimizing Responsive Neurostimulation in Drug-Resistant Epilepsy: A Systematic Review of Detection and Stimulation Parameters

This project outlines the protocol for a systematic review investigating the optimization of detection algorithms and stimulation parameters in Responsive Neurostimulation (RNS) for drug-resistant epilepsy.
Alaleh Alizadeh
core   +5 more sources

Centromedian thalamic neuromodulation for the treatment of idiopathic generalized epilepsy

Frontiers in Human Neuroscience, 2022
Idiopathic generalized epilepsy (IGE) is a common type of epilepsy and despite an increase in the number of available anti-seizure medications, approximately 20–30% of people with IGE continue to experience seizures despite adequate medication trials ...
Andrew J. Zillgitt, M. Ayman Haykal, Ahmad Chehab, Michael D. Staudt, Michael D. Staudt, Michael D. Staudt   +5 more
doaj   +1 more source

Stimulation better targets fast‐ripple generating networks in super responders to the responsive neurostimulator system

Epilepsia, 2022
Abstract How responsive neurostimulation (RNS) decreases seizure frequency is unclear. Stimulation may alter epileptic networks during inter‐ictal epochs. Definitions of the epileptic network vary but fast ripples (FRs) may be an important substrate.
Shennan Aibel Weiss, Daniel Rubinstein, John Stern, Dawn Eliashiv, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Jerome Engel, Richard Staba, Michael R. Sperling   +9 more
openaire   +2 more sources

Antiepileptic drug optimization using ambulatory electrocorticographic data from an implanted brain‐responsive neurostimulator

Clinical Case Reports, 2020
Effectiveness of antiepileptic drugs (AEDs) has been traditionally monitored by patient‐reported seizures. A 31‐year‐old male patient was treated with a responsive neurostimulation system (RNS).
Elysia Tjong, Yen‐Yi Peng
doaj   +1 more source