Results 31 to 40 of about 409,301 (101)

Thalamic responsive neurostimulation for the treatment of refractory epilepsy: an individual patient data meta-analysis

, 2023
OBJECTIVE In recent years, the treatment of drug-resistant epilepsy (DRE) has made greater use of surgery and expanded options for neurostimulation or neuromodulation.
Marytery Fajardo, Bystrom, Lauren L., Levy, Adam S., Wang, Shelly, Lauren L. Bystrom, Fajardo, Marytery, Adam S. Levy, Erik C. Brown, Shelly Wang, Brown, Erik C., Wang, Kelly   +10 more
core   +1 more source

Intracranial electroencephalographic biomarker predicts effective responsive neurostimulation for epilepsy prior to treatment [PDF]

, 2022
OBJECTIVE: Despite the overall success of responsive neurostimulation (RNS) therapy for drug-resistant focal epilepsy, clinical outcomes in individuals vary significantly and are hard to predict.
Ankit N. Khambhati, Edward F. Chang, Bernabei, John M, Bassett, Dani S., Lucas, Timothy, Davis, Kathryn A, Brian Litt, Jay Jeschke, Kathryn A. Davis, Bassett, Dani S, Mouchtaris, Sofia, Dani S. Bassett, Bernabei, John M., Scheid, Brittany H, Chang, Edward F., Friedman, Daniel, Scheid, Brittany H., Jeschke, Jay, Chang, Edward F, Litt, Brian, Davis, Kathryn A., Danielle Becker, Becker, Danielle, Doyle, Werner, Rao, Vikram R, Brittany H. Scheid, Vikram R. Rao, Khambhati, Ankit N, John M. Bernabei, Timothy Lucas, Khambhati, Ankit N., Rao, Vikram R., Sofia Mouchtaris, Daniel Friedman, Werner Doyle   +34 more
core   +1 more source

Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial [PDF]

Epilepsia, 2014
SummaryObjectiveTo demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partial onset seizures arising from one or two seizure foci.MethodsRandomized multicenter double‐blinded controlled trial of responsive focal ...
Heck, Christianne N, King‐Stephens, David, Massey, Andrew D, Nair, Dileep R, Jobst, Barbara C, Barkley, Gregory L, Salanova, Vicenta, Cole, Andrew J, Smith, Michael C, Gwinn, Ryder P, Skidmore, Christopher, Van Ness, Paul C, Bergey, Gregory K, Park, Yong D, Miller, Ian, Geller, Eric, Rutecki, Paul A, Zimmerman, Richard, Spencer, David C, Goldman, Alica, Edwards, Jonathan C, Leiphart, James W, Wharen, Robert E, Fessler, James, Fountain, Nathan B, Worrell, Gregory A, Gross, Robert E, Eisenschenk, Stephan, Duckrow, Robert B, Hirsch, Lawrence J, Bazil, Carl, O'Donovan, Cormac A, Sun, Felice T, Courtney, Tracy A, Seale, Cairn G, Morrell, Martha J   +35 more
openaire   +4 more sources

Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy

Annals of Clinical and Translational Neurology, 2019
Responsive neurostimulation (RNS) has emerged as an adjunctive treatment modality for patients with intractable focal epilepsy who are not surgical candidates or have more than one ictal onset focus.
Aline Herlopian, Sydney S. Cash, Emad M. Eskandar, Tara Jennings, Andrew J. Cole   +4 more
doaj   +1 more source

Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism

Annals of Clinical and Translational Neurology, 2020
The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug‐resistant epilepsy secondary to Lennox‐Gastaut Syndrome (LGS ...
Churl‐Su Kwon, Alexander J. Schupper, Madeline C. Fields, Lara V. Marcuse, Maite La Vega‐Talbott, Fedor Panov, Saadi Ghatan   +6 more
doaj   +1 more source

Case Report: Responsive Neurostimulation of the Centromedian Thalamic Nucleus for the Detection and Treatment of Seizures in Pediatric Primary Generalized Epilepsy

Frontiers in Neurology, 2021
Up to 20% of pediatric patients with primary generalized epilepsy (PGE) will not respond effectively to medication for seizure control. Responsive neurostimulation (RNS) is a promising therapy for pediatric patients with drug-resistant epilepsy and has ...
William P. Welch, Jasmine L. Hect, Taylor J. Abel, Taylor J. Abel   +3 more
doaj   +1 more source

Robotic Orthogonal Implantation of Responsive Neurostimulation (RNS) Depth Electrodes in the Mesial Temporal Lobe: Case Series

Operative Neurosurgery, 2019
Abstract BACKGROUND Responsive neurostimulation (RNS) is a closed-loop neurostimulation modality for treating intractable epilepsy in patients who are not candidates for resection. In the past, implantation of depth electrodes was done through a transoccipital approach that transverses the hippocampus. There have been
Alvin Y, Chan, Diem Kieu, Tran, Michelle R, Paff, Kamran, Urgun, Frank P K, Hsu, Sumeet, Vadera   +5 more
openaire   +2 more sources

Responsive Neurostimulation of the Thalamus for the Treatment of Refractory Epilepsy

Frontiers in Human Neuroscience, 2022
IntroductionOne-third of patients with epilepsy continue to have seizures despite antiepileptic medications. Some of these refractory patients may not be candidates for surgical resection primarily because the seizure onset zones (SOZs) involve both ...
Jorge A. Roa, Marina Abramova, Madeline Fields, Maite La Vega-Talbott, Jiyeoun Yoo, Lara Marcuse, Steven Wolf, Patricia McGoldrick, Saadi Ghatan, Fedor Panov   +9 more
doaj   +1 more source

Emerging Trends in Neuromodulation for Treatment of Drug-Resistant Epilepsy

Frontiers in Pain Research, 2022
Epilepsy is a neurological disorder that affects more than 70 million people globally. A considerable proportion of epilepsy is resistant to anti-epileptic drugs (AED).
Mohamed Abouelleil, Nachiket Deshpande, Rushna Ali   +2 more
doaj   +1 more source

Wirksamkeit der iktalen Neurostimulation

, 2023
HintergrundDie Neurostimulation ist ein etabliertes Verfahren zur Behandlung pharmakoresistenter Epilepsien, wobei Ergebnisse aus kontrollierten und unkontrollierten klinischen Studien auf eine durch Neuromodulation vermittelte mit der Therapiedauer ...
Hirsch, Martin, Schulze-Bonhage, Andreas
core   +1 more source