Results 161 to 170 of about 1,137,892 (286)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Using nucleolytic toxins as restriction enzymes enables new RNA applications. [PDF]

Nucleic Acids Res
Rothweiler U, Gundesø SE, Mikalsen EW, Svenning S, Singh M, Combes F, Pettersson FJ, Mangold A, Piotrowski Y, Schwab F, Lanes O, Striberny BK.   +11 more
europepmc   +1 more source

Restriction Enzymes as a Target for DNA-Based Sensing and Structural Rearrangement. [PDF]

ACS Omega, 2018
Buckhout-White S, Person C, Medintz IL, Goldman ER.   +3 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

An enterococcal phage protein inhibits type IV restriction enzymes involved in antiphage defense. [PDF]

Nat Commun
Bullen NP, Johnson CN, Andersen SE, Arya G, Marotta SR, Lee YJ, Weigele PR, Whitney JC, Duerkop BA.   +8 more
europepmc   +1 more source

Determining if DNA Stained with a Cyanine Dye Can Be Digested with Restriction Enzymes. [PDF]

J Vis Exp, 2018
Maschmann A, Masters C, Davison M, Lallman J, Thompson D, Kounovsky-Shafer KL.   +5 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

A New Escherichia coli Entry Vector Series (pIIS18) for Seamless Gene Cloning Using Type IIS Restriction Enzymes. [PDF]

Microbiol Resour Announc, 2019
Altaib H, Ozaki Y, Kozakai T, Badr Y, Nomura I, Suzuki T.   +5 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Typing of Campylobacter jejuni isolated from poultry on the basis of flaA-RFLP by various restriction enzymes. [PDF]

Vet Anim Sci, 2018
Yadav R, Yadav J, Maherchandani S, Kashyap SK.   +3 more
europepmc   +1 more source