Results 81 to 90 of about 268,348 (303)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Bioinformatic Analysis Strategy in Restriction Enzyme Selection for Indonesian Panulirus homarus Identification by PCR-RFLP

Journal of Mathematical and Fundamental Sciences
The spiny lobster (Panulirus homarus) is a valuable fishery commodity in Indonesia, particularly in its juvenile life form. However, identifying the early life forms of the spiny lobster can be challenging, as it exhibits similar morphological features ...
Indriatmoko Indriatmoko, Adi Pancoro
doaj   +1 more source

Base-excision restriction enzymes: expanding the world of epigenetic immune systems. [PDF]

DNA Res, 2023
Kojima KK, Kobayashi I.
europepmc   +1 more source

DNA translocation blockage, a general mechanism of cleavage site selection by type I restriction enzymes [PDF]

, 1999
Pavel Janščák, Maria P. MacWilliams, Ursula Sandmeier, Valakunja Nagaraja, Thomas A. Bickle   +4 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Optimización del método SCAR (Sequence Characterized Amplified Region) que favorece el aislamiento de loci polimórficos para estudios filogenéticos en taxa cercanamente relacionados Optimization to the SCAR (Sequence Characterized Amplified Region) favors the isolation of polymorphic loci for phylogenetic studies in closely related taxa

Revista Mexicana de Biodiversidad, 2010
Las secuencias génicas han contribuido enormemente a los estudios filogenéticos en plantas. Sin embargo, una desventaja importante en las secuencias de varios loci es su baja resolución filogenética para resolver las relaciones de taxa cercanamente ...
Dolores González
doaj  

Identification of blood meal sources of Lutzomyia longipalpis using polymerase chain reaction-restriction fragment length polymorphism analysis of the cytochrome B gene

Memorias do Instituto Oswaldo Cruz, 2014
An analysis of the dietary content of haematophagous insects can provide important information about the transmission networks of certain zoonoses.
Vítor Yamashiro Rocha Soares, Jailthon Carlos da Silva, Kleverton Ribeiro da Silva, Maria do Socorro Pires e Cruz, Marcos Pérsio Dantas Santos, Paulo Eduardo Martins Ribolla, Diego Peres Alonso, Luiz Felipe Leomil Coelho, Dorcas Lamounier Costa, Carlos Henrique Nery Costa   +9 more
doaj   +1 more source

DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA. [PDF]

Sci Adv, 2023
Viswanathan R, Cheruba E, Wong PM, Yi Y, Ngang S, Chong DQ, Loh YH, Tan IB, Cheow LF.   +8 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Quantification of protein copy number in yeast: the NAD+ metabolome.

PLoS ONE, 2014
Saccharomyces cerevisiae is calorie-restricted by lowering glucose from 2% to 0.5%. Under low glucose conditions, replicative lifespan is extended in a manner that depends on the NAD+-dependent protein lysine deacetylase Sir2 and NAD+ salvage enzymes ...
Szu-Chieh Mei, Charles Brenner
doaj   +1 more source