Results 71 to 80 of about 1,662,191 (275)

Exploring Preferences for a Digital Single‐Session Intervention for Adolescent Siblings of Youth With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro, Sarah Silver, Prishi Patel, Meredith K. Reffner Collins, Kimberly S. Canter, Stephanie Fooks‐Parker, Michael Amylon, Shawna V. Hudson, Jessica L. Schleider, Melissa A. Alderfer, Katie A. Devine   +10 more
wiley   +1 more source

Nasal mucus-derived KLK13 restricts SARS-CoV-2 infection via proteolytic cleavage of spike

mBio
The epithelial cilia are the first line of defense against respiratory pathogens. For the first time, we found that Kallikrein-related peptidase 13 (KLK13), a serine protease expressed in airway ciliated epithelial cells with cell type specificity, was ...
Wenying Cao, Ningze Zheng, Hehe Cao, Ran Chen, Jianheng Chen, Xueyi Deng, Hui Zhang, Shuofeng Yuan, Guigen Zhang   +8 more
doaj   +1 more source

APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1

mBio, 2020
Humans encode proteins, called restriction factors, that inhibit replication of viruses such as HIV-1. The members of one family of antiviral proteins, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; shortened here to A3), act
Mollie M. McDonnell, Kate H. D. Crawford, Adam S. Dingens, Jesse D. Bloom, Michael Emerman   +4 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Auctions with Severely Bounded Communication

, 2011
We study auctions with severe bounds on the communication allowed: each bidder may only transmit t bits of information to the auctioneer. We consider both welfare- and profit-maximizing auctions under this communication restriction. For both measures, we
Blumrosen, L., Nisan, N., Segal, I.
core   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction

Journal of Virology
SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its ...
Pak-Hin Hinson Cheung, Hua Yang, Li Wu
doaj   +1 more source

Effect of minimal length uncertainty on the mass-radius relation of white dwarfs

, 2017
Generalized uncertainty relation that carries the imprint of quantum gravity introduces a minimal length scale into the description of space-time. It effectively changes the invariant measure of the phase space through a factor $(1+\beta \mathbf{p}^2 ...
Mathew, Arun, Nandy, Malay K.
core   +1 more source

Medical oncology patients' preferences with regard to health care: development of a patient-driven questionnaire [PDF]

, 2009
BACKGROUND: To improve quality of care for cancer patients, it is important to have an insight on the patient's view on health care and on their specific wishes, needs and preferences, without restriction and without influence of researchers and health ...
Avis, Bredart, Clark, Committee on Quality of Health Care in America IoM, Crawford, de Kok, Department of Health, Gesell, Gilmore, Glaser, Gourdji, Groenewegen, Kitzinger, Kleeberg, Morgan, Nunnally, Polit, Richards, Richardson, Sandoval, Sandoval, Sixma, Skarstein, Tamburini, Tamburini, The Advisory Board Company, Oncology Roundtable, Turhal, van Campen, Wiggers   +28 more
core   +3 more sources

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source