Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans [PDF]
, 2014 To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Airaksinen +40 more
core +1 more source
Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype. [PDF]
, 1996 It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome.
Deckart, H. F. +15 more
core +1 more source
Resonance energy transfer: The unified theory revisited [PDF]
, 2003 Resonanceenergy transfer (RET) is the principal mechanism for the intermolecular or intramolecular redistribution of electronic energy following molecular excitation.
Adronov A. +7 more
core +1 more source
Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer [PDF]
, 2016 Medullary thyroid cancer (MTC) relies on the aberrant activation of RET proto-oncogene. Though targeted approaches (i.e., tyrosine kinase inhibitors) are available, the absence of complete responses and the onset of resistance mechanisms indicate the ...
Beretta, Giovanni L +11 more
core +1 more source
Current status of the prognostic molecular markers in medullary thyroid carcinoma
Endocrine Connections, 2020 Medullary thyroid cancer (MTC) is a rare thyroid malignancy, which arises from parafollicular C-cells. It occurs in the hereditary or sporadic form. Hereditary type is a consequence of activation of the RET proto-oncogene by germline mutations, whereas ...
Malgorzata Oczko-Wojciechowska +4 more
doaj +1 more source
Quantum electrodynamics of resonance energy transfer in nanowire systems [PDF]
, 2016 Nonradiative resonance energy transfer (RET) provides the ability to transfer excitation energy between contiguous nanowires (NWs) with high efficiency under certain conditions.
Andrews, David L. +2 more
core +1 more source
Precision therapy for RET-altered cancers with RET inhibitors [PDF]
Trends in Cancer, 2021 Rearranged during transfection (RET) is involved in the physiological development of some organ systems. Activating RET alterations via either gene fusions or point mutations are potent oncogenic drivers in non-small cell lung cancer, thyroid cancer, and in multiple diverse cancers. RET-altered cancers were initially treated with multikinase inhibitors
Kyaw Z. Thein +4 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
RET mutated C-cells proliferate more rapidly than non-mutated neoplastic cells
Endocrine Connections, 2021 A statistically significant higher prevalence of the RET p.Met918Thr somatic mutation, identified by direct sequencing, was previously reported in MTC > 2 cm than in smaller tumors. Aim of this study was to correlate the full RET and RAS mutation profile,
Cristina Romei +9 more
doaj +1 more source
Complete element abundances of nine stars in the r-process galaxy Reticulum II [PDF]
, 2016 We present chemical abundances derived from high-resolution Magellan/MIKE spectra of the nine brightest known red giant members of the ultra-faint dwarf galaxy Reticulum II.
Chiti, Anirudh +3 more
core +2 more sources