Results 21 to 30 of about 60,412 (260)

THE SIGNIFICANCE OF NATO'S STRATEGIC CGNCEPT FOR DEFENCE AND SECURITY, ADOPTED IN LISBON IN NOVEMBER 2010 [PDF]

Annals: Series on Military Sciences, 2011
The Heads of State and Government of the NATO nations decided to fulfill the Alliance's mission in ensuring "their common defense and security”. When NATO has put into practice this Strategic Concept, the Alliance will be more "effective in a changing ...
Eugen BĂDĂLAN, Eugen SITEANU
doaj  

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

THE NUCLEAR TECHNOLOGY IMPACT ON SUSTAINABLE DEVELOPMENT AND SECURITY [PDF]

Annals: Series on Military Sciences, 2013
On one hand, the nuclear technologies have a positive impact on sustainable development and security, but, on the other hand, they produce insecurity and bad prejudices on the sustainable development through the risks, threats and dangers which are ...
Eugen SITEANU, Benone ANDRONIC
doaj  

2012 European Thyroid Association Guidelines for Metastatic Medullary Thyroid Cancer

Эндокринная хирургия, 2013
Distant metastases are the main cause of death in patients with medullary thyroid cancer (MTC). These 21 recommendations focus on MTC patients with distant metastases and a detailed followup protocol of patients with biochemical or imaging evidence of ...
V V Voskoboynikov, D G Bel'tsevich, V E Vanushko   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

ROMANIAS DEFENCE INFRASTRUCTURE DEVELOPMENT [PDF]

Annals: Series on Military Sciences, 2011
It is obvious that the infrastructure for defense represents a vital necessity for every nation in the context of the present day processes of European and international integration. Provision of current security, both at the European and national levels,
Eugen BĂDĂLAN, Eugen SITEANU
doaj  

RET mutated C-cells proliferate more rapidly than non-mutated neoplastic cells

Endocrine Connections, 2021
A statistically significant higher prevalence of the RET p.Met918Thr somatic mutation, identified by direct sequencing, was previously reported in MTC > 2 cm than in smaller tumors. Aim of this study was to correlate the full RET and RAS mutation profile,
Cristina Romei, Teresa Ramone, Chiara Mulè, Alessandro Prete, Virginia Cappagli, Loredana Lorusso, Liborio Torregrossa, Fulvio Basolo, Raffaele Ciampi, Rossella Elisei   +9 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

THE TOPICALITY OF RULER NEAGOE BASARAB'S MILITARY THINKING ON WAR AND ARMY [PDF]

Annals: Series on Military Sciences, 2010
Our great poet Vasile Alecsandri, making reference to the brilliant minds and epochal achievements of waivodes, rulers and past famous men of culture of the Romanian people, who served and protected in an exemplary manner our Country, Origin and ...
FIorian TUCĂ, Eugen SITEANU
doaj