H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury. [PDF]
Adv Sci (Weinh)Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Hong C +13 more
europepmc +2 more sources
Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans [PDF]
, 2014 To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Martínez-Torres, R.J. +8 more
core +1 more source
Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype. [PDF]
, 1996 It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome.
Rendl, J. +15 more
core +1 more source
DNA topoisomerases participate in fragility of the oncogene RET [PDF]
, 2013 Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Yuh-Hwa Wang (457429) +25 more
core +2 more sources
The receptor tyrosine kinase RET is a Hsp90 client protein and is degraded upon exposure to 17-AAG. [PDF]
, 2009 Molecular alterations of the receptor tyrosin kinase RET are involved in the pathogenesis of thyroid cancer. Germline point mutations in the extracellular and intracellular domains of the receptor are responsible of a group of inherited cancer diseases ...
Alfano, Luigi
core +2 more sources
Current status of the prognostic molecular markers in medullary thyroid carcinoma
Endocrine Connections, 2020 Medullary thyroid cancer (MTC) is a rare thyroid malignancy, which arises from parafollicular C-cells. It occurs in the hereditary or sporadic form. Hereditary type is a consequence of activation of the RET proto-oncogene by germline mutations, whereas ...
Malgorzata Oczko-Wojciechowska +4 more
doaj +1 more source
Non-small-cell lung cancer: how to manage RET-positive disease
Drugs in Context, 2022 Targeted therapy has dramatically changed the history and outcomes of oncogene-addicted non-small-cell lung cancer (NSCLC). RET rearrangements are typically observed in about 1–2% of NSCLC, resulting in constitutive activation of downstream signalling ...
Elisa Andrini +6 more
doaj +1 more source
Germline genetic variants in pheochromocytoma/paraganglioma: single-center experience
Endocrine Oncology, 2023 Pheochromocytoma and paragangliomas (PPGLs) are rare neuroendocrine tumors carrying 25–40% pathogenic germline gene variants (PGVs). We evaluated clinical, laboratory, and germline molecular profile of 115 patients with pathologic (14 patients were ...
José V Lima Jr +6 more
doaj +1 more source
COMMAND AND CONTROL IN MODERN MILITARY OPERATIONS [PDF]
Annals: Series on Military Sciences, 2009 "A strong collective defense of our populations, territory and forces is the core purpose of the Alliance and remains our most important security task". A memorable sentence from the Final Declaration of the Kohl/Strasbourg Summit, in April 2009, which,
Eugen BADALAN, Florian PINTA
doaj
Passage - Tidsskrift for litteratur og kritik, 2009 Henrik Skov Nielsen: At give ret, ret at ...
openaire +4 more sources