Results 21 to 30 of about 501,662 (286)
RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies [PDF]
Journal of Thoracic Oncology, 2020 Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) have shown unprecedented efficacy in tumors positive for RET fusions or mutations, notably RET fusion-positive NSCLC and RET-mutated medullary thyroid cancer (MTC).
Solomon, BJ +30 more
openaire +3 more sources
Predicting signatures of anisotropic resonance energy transfer in dye-functionalized nanoparticles
, 2016 Resonance energy transfer (RET) is an inherently anisotropic process. Even the simplest, well-known F\"orster theory, based on the transition dipole-dipole coupling, implicitly incorporates the anisotropic character of RET.
Bertoni, Andrea +4 more
core +1 more source
Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia [PDF]
, 2017 Expression of the Ret receptor tyrosine kinase is a defining feature of enteric neurons. Its importance is underscored by the effects of its mutation in Hirschsprung disease, leading to absence of gut innervation and severe gastrointestinal symptoms.
Burns, Alan J. +15 more
core +2 more sources
COMMAND AND CONTROL IN MODERN MILITARY OPERATIONS [PDF]
Annals: Series on Military Sciences, 2009 "A strong collective defense of our populations, territory and forces is the core purpose of the Alliance and remains our most important security task". A memorable sentence from the Final Declaration of the Kohl/Strasbourg Summit, in April 2009, which,
Eugen BADALAN, Florian PINTA
doaj
Endocrine Connections, 2020 Objective: Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases.
Louise Vølund Larsen +34 more
doaj +1 more source
Is there any justice in being other than 'white' in Britain? [PDF]
, 2015 Over the past five years numerous headlines have deconstructed racism as a political event. There is no escape from the politics of these events in the media; for example, Racism on the Rise in Britain’ (Guardian, 2014); Immigrants make UK racist (The ...
Flint, K, Peart, S
core +1 more source
RET kinase inhibitors for RET-altered thyroid cancers
Therapeutic Advances in Medical Oncology, 2022 Precision oncology has opened a new era in cancer treatment focused on targeting specific cellular pathways directly involved in tumorigenesis. The REarrangement during Transfection ( RET) proto-oncogene is involved in the pathogenesis of various thyroid cancer subtypes.
Danica M. Vodopivec, Mimi I. Hu
openaire +3 more sources
The Mouse That Roared: The Democratic Movement in Hong Kong [PDF]
Contemporary Chinese Political Economy and Strategic Relations: An International Journal, 2016 The popular uprising in recent years in Hong Kong – “Occupy Central” a.k.a. Umbrella Movement – has again brought to the fore the question of the Special Administrative Region’s relationship with Mainland China post-1997 “handover” of the territory by ...
Arif Dirlik
doaj
Non-small-cell lung cancer: how to manage RET-positive disease
Drugs in Context, 2022 Targeted therapy has dramatically changed the history and outcomes of oncogene-addicted non-small-cell lung cancer (NSCLC). RET rearrangements are typically observed in about 1–2% of NSCLC, resulting in constitutive activation of downstream signalling ...
Elisa Andrini +6 more
doaj +1 more source
BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer [PDF]
, 2009 Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, RET and neurotrophic tyrosine kinase receptor type I (NTRK1)
Baumgartner, Adolf +6 more
core +2 more sources