Results 11 to 20 of about 19,866 (162)

cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates [PDF]

Stem Cell Research & Therapy, 2021
Background Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following retinal photoreceptor precursors ...
Swathi Lingam, Zengping Liu, Binxia Yang, Wendy Wong, Bhav Harshad Parikh, Jun Yi Ong, Debbie Goh, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Gavin S. W. Tan, Graham E. Holder, Kakkad Regha, Veluchamy Amutha Barathi, Walter Hunziker, Gopal Lingam, Xianmin Zeng, Xinyi Su   +16 more
doaj   +3 more sources

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states [PDF]

Scientific Reports, 2021
Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
doaj   +4 more sources

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2. [PDF]

Free Radic Biol Med, 2019
Sigma 1 receptor (Sig1R), a putative molecular chaperone, has emerged as a novel therapeutic target for retinal degenerative disease. Earlier studies showed that activation of Sig1R via the high-affinity ligand (+)-pentazocine ((+)-PTZ) induced profound rescue of cone photoreceptor cells in the rd10 mouse model of retinitis pigmentosa; however the ...
Wang J, Zhao J, Cui X, Mysona BA, Navneet S, Saul A, Ahuja M, Lambert N, Gazaryan IG, Thomas B, Bollinger KE, Smith SB.   +11 more
europepmc   +4 more sources

Taurine deficiency damages retinal neurones: cone photoreceptors and retinal ganglion cells [PDF]

Amino Acids, 2012
In 1970s, taurine deficiency was reported to induce photoreceptor degeneration in cats and rats. Recently, we found that taurine deficiency contributes to the retinal toxicity of vigabatrin, an antiepileptic drug. However, in this toxicity, retinal ganglion cells were degenerating in parallel to cone photoreceptors.
Gaucher, David, Arnault, Emilie, Husson, Zoé, Froger, Nicolas, Dubus, Elisabeth, Gondouin, Pauline, Dherbecourt, Diane, Degardin, Julie, Simonutti, Manuel, Fouquet, Stéphane, Benahmed, M., Elbayed, K., Namer, Izzie-Jacques, Massin, Pascale, Sahel, José-Alain, Picaud, Serge   +15 more
openaire   +2 more sources

Necrotic cone photoreceptor cell death in retinitis pigmentosa [PDF]

Cell Death & Disease, 2015
Retinitis pigmentosa (RP) comprises a group of inherited retinal degenerations, resulting from rod and cone photoreceptor cell death. Genetic studies have identified mutations in more than 50 genes—most of which encode rod-related molecules—that are associated with RP.
Murakami, Y, Ikeda, Y, Nakatake, S, Miller, J W, Vavvas, D G, Sonoda, K H, Ishibashi, T   +6 more
openaire   +2 more sources

Effect of Direct Current Electric Fields on Cone Like Retinal Photoreceptor Cells

Frontiers in Bioscience-Landmark, 2022
Introduction: Studies show that electric fields are used as therapy during nerve and tissue injuries along with trans-retinal stimulation. However, cellular and molecular changes induced by such treatments remain largely unknown especially in retinal photoreceptor cells.
Cora Roehlecke, Sergio S. Mühlen, Richard H.W. Funk, Dimitra Alexopoulou, Daniela Calzia, Sharanya Bola, Juliana Guerra-Hühne   +6 more
openaire   +4 more sources

NRL −/− gene edited human embryonic stem cells generate rod-deficient retinal organoids enriched in S-cone-like photoreceptors [PDF]

Stem Cells, 2021
Abstract Organoid cultures represent a unique tool to investigate the developmental complexity of tissues like the human retina. NRL is a transcription factor required for the specification and homeostasis of mammalian rod photoreceptors.
Elisa Cuevas, Daniel L. Holder, Ashwak H. Alshehri, Julie Tréguier, Jörn Lakowski, Jane C. Sowden   +5 more
openaire   +5 more sources

Melanopsin Retinal Ganglion Cells Regulate Cone Photoreceptor Lamination in the Mouse Retina [PDF]

Cell Reports, 2018
Newborn neurons follow molecular cues to reach their final destination, but whether early life experience influences lamination remains largely unexplored. As light is among the first stimuli to reach the developing nervous system via intrinsically photosensitive retinal ganglion cells (ipRGCs), we asked whether ipRGCs could affect lamination in the ...
Adele R. Tufford, Jessica R. Onyak, Katelyn B. Sondereker, Jasmine A. Lucas, Aaron M. Earley, Pierre Mattar, Samer Hattar, Tiffany M. Schmidt, Jordan M. Renna, Michel Cayouette   +9 more
openaire   +3 more sources

Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light‐induced damage [PDF]

Journal of Neurochemistry, 2012
J. Neurochem. (2012) 121, 146–156.AbstractAll‐trans‐retinal and its condensation‐products can cause retinal degeneration in a light‐dependent manner and contribute to the pathogenesis of human macular diseases such as Stargardt’s disease and age‐related macular degeneration.
Kiichiro, Okano, Akiko, Maeda, Yu, Chen, Vishal, Chauhan, Johnny, Tang, Grazyna, Palczewska, Tsutomu, Sakai, Hiroshi, Tsuneoka, Krzysztof, Palczewski, Tadao, Maeda   +9 more
openaire   +2 more sources

Single-cell transcriptomic profiling in inherited retinal degeneration reveals distinct metabolic pathways in rod and cone photoreceptors

International Journal of Molecular Sciences, 2022
AbstractThe cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood. The aim of this study was to systematically map the transcriptional changes that occur in the degenerating mouse retina at the single cell level.
Yiyi Chen, Yujie Dong, Jie Yan, Lan Wang, Shirley Yu, Kangwei Jiao, François Paquet-Durand   +6 more
openaire   +2 more sources