Results 11 to 20 of about 110,459 (310)

Peripapillary Intravitreal Injection Improves AAV-Mediated Retinal Transduction

Molecular Therapy: Methods & Clinical Development, 2020
The intravitreal (IVT) injection method is a choice when targeting the inner retina for gene therapy. However, the transduction efficiency of adeno-associated virus (AAV) vectors administered by the IVT route is usually low and may be affected by several
Sanjar Batirovich Madrakhimov, Jin Young Yang, Dong Hyuck Ahn, Jung Woo Han, Tae Ho Ha, Tae Kwann Park   +5 more
doaj   +1 more source

The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage

Journal of Neuroinflammation, 2023
Background Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal domain (BET) proteins are epigenetic
Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li, Lili Gong   +13 more
doaj   +1 more source

Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium

Antioxidants, 2021
Erythropoietin (EPO) plays an important role in erythropoiesis by its action in blocking apoptosis of progenitor cells and protects both photoreceptors and retinal ganglion cells from induced or inherited degeneration.
Manas R. Biswal, Zhaoyao Wang, Ryan J. Paulson, Rukshana R. Uddin, Yao Tong, Ping Zhu, Hong Li, Alfred S. Lewin   +7 more
doaj   +1 more source

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

Scientific Reports, 2021
Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva, Noga Gershoni-Emek, Luana Naia, Philip Ly, Sandra Mota, Ana Cristina Rego, Michael R. Hayden, Leonard A. Levin   +7 more
doaj   +1 more source

Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration

Molecular Therapy: Methods & Clinical Development, 2019
Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the ...
Hongman Song, Ronald A. Bush, Yong Zeng, Haohua Qian, Zhijian Wu, Paul A. Sieving   +5 more
doaj   +1 more source

Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration

Journal of Neuroinflammation, 2023
Background Retinal degeneration is a disease affecting the eye, which is an immune-privileged site because of its anatomical and physiological properties.
Federica M. Conedera, Judith M. Runnels, Jens V. Stein, Clemens Alt, Volker Enzmann, Charles P. Lin   +5 more
doaj   +1 more source

HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration

Redox Biology, 2021
Oxidative stress-mediated retinal pigment epithelium (RPE) degeneration plays a vital role in retinal degeneration with irreversible visual impairment, most notably in age-related macular degeneration (AMD), but a key pathogenic factor and the targeted ...
Zhimin Tang, Yahan Ju, Xiaochan Dai, Ni Ni, Yan Liu, Dandan Zhang, Huiqin Gao, Hao Sun, Jing Zhang, Ping Gu   +9 more
doaj   +1 more source

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV

Cell Communication and Signaling, 2019
Background The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure.
Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park, Tae Kwann Park   +7 more
doaj   +1 more source

Targeting molecular pathways for the treatment of inherited retinal degeneration

Neural Regeneration Research, 2020
Inherited retinal degeneration is a major cause of incurable blindness characterized by loss of retinal photoreceptor cells. Inherited retinal degeneration is characterized by high genetic and phenotypic heterogeneity with several genes mutated in ...
Meltem Kutluer, Li Huang, Valeria Marigo
doaj   +1 more source

An Unusual Case of Extensive Lattice Degeneration and Retinal Detachment [PDF]

Journal of Clinical and Diagnostic Research, 2016
Lattice degeneration of the retina is not infrequently encountered on a dilated retinal examination and many of them do not need any intervention. We report a case of atypical lattice degeneration variant with peripheral retinal detachment.
David J. Mathew, Saurabh Kumar Sarma, Jennifer V. Basaiawmoit   +2 more
doaj   +1 more source