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Retinal Degeneration

Methods in Molecular Biology, 2020
OVERVIEW  ―Retinal‖ refers to the retina; the retina is the innermost lining layer (located on the back surface) of the eyeball; it contains the light-sensitive rods and cones and other cells that convert images into signals and send messages to the ...
B. Weber, T. Langmann
semanticscholar   +1 more source

The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage

Journal of Neuroinflammation, 2023
Background Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal domain (BET) proteins are epigenetic
Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li, Lili Gong   +13 more
doaj   +1 more source

Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium

Antioxidants, 2021
Erythropoietin (EPO) plays an important role in erythropoiesis by its action in blocking apoptosis of progenitor cells and protects both photoreceptors and retinal ganglion cells from induced or inherited degeneration.
Manas R. Biswal, Zhaoyao Wang, Ryan J. Paulson, Rukshana R. Uddin, Yao Tong, Ping Zhu, Hong Li, Alfred S. Lewin   +7 more
doaj   +1 more source

Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction.

Journal of Clinical Investigation, 2020
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism governing pericyte degeneration is poorly understood.
Qin Jiang, Chang Liu, Chaopeng Li, Shanshan Xu, Mudi Yao, Hui-min Ge, Yanan Sun, Xiu-Miao Li, Shu-jie Zhang, Kun Shan, Baihui Liu, Jin Yao, Chen Zhao, B. Yan   +13 more
semanticscholar   +1 more source

Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration

Journal of Neuroinflammation, 2023
Background Retinal degeneration is a disease affecting the eye, which is an immune-privileged site because of its anatomical and physiological properties.
Federica M. Conedera, Judith M. Runnels, Jens V. Stein, Clemens Alt, Volker Enzmann, Charles P. Lin   +5 more
doaj   +1 more source

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

Science Translational Medicine, 2019
A retinal pigment epithelial patch derived from mutation-free pluripotent stem cells shows therapeutic effects in rats and pigs. A pipeline for retinal stem cell therapy Autologous induced pluripotent stem cell (iPSC)–derived retinal pigment epithelium ...
Ruchi Sharma, V. Khristov, Aaron Rising, B. Jha, R. Dejene, Nathan A Hotaling, Yichao Li, Jonathan Stoddard, Casey Stankewicz, Qin Wan, Connie S. Zhang, M. Campos, K. Miyagishima, David M. McGaughey, R. Villasmil, M. Mattapallil, B. Stanzel, H. Qian, Wai T. Wong, L. Chase, S. Charles, T. Mcgill, Sheldon S Miller, A. Maminishkis, J. Amaral, K. Bharti   +25 more
semanticscholar   +1 more source

Associations of Variation in Retinal Thickness With Visual Acuity and Anatomic Outcomes in Eyes With Neovascular Age-Related Macular Degeneration Lesions Treated With Anti–Vascular Endothelial Growth Factor Agents

JAMA ophthalmology, 2020
Key Points Question Are fluctuations in retinal thickness associated with visual and anatomic outcomes in eyes with neovascular age-related macular degeneration treated with anti–vascular endothelial growth factor drugs?
R. Evans, B. Reeves, M. Maguire, Daniel F. Martin, A. Muldrew, T. Peto, C. Rogers, U. Chakravarthy   +7 more
semanticscholar   +1 more source

An Unusual Case of Extensive Lattice Degeneration and Retinal Detachment [PDF]

Journal of Clinical and Diagnostic Research, 2016
Lattice degeneration of the retina is not infrequently encountered on a dilated retinal examination and many of them do not need any intervention. We report a case of atypical lattice degeneration variant with peripheral retinal detachment.
David J. Mathew, Saurabh Kumar Sarma, Jennifer V. Basaiawmoit   +2 more
doaj   +1 more source

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

Scientific Reports, 2021
Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva, Noga Gershoni-Emek, Luana Naia, Philip Ly, Sandra Mota, Ana Cristina Rego, Michael R. Hayden, Leonard A. Levin   +7 more
doaj   +1 more source

Recent developments of neuroprotective agents for degenerative retinal disorders

Neural Regeneration Research, 2022
Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which are caused by a group of retinal diseases affecting various age groups, and increasingly prevalent in the ...
Kepeng Ou, Youjian Li, Ling Liu, Hua Li, Katherine Cox, Jiahui Wu, Jian Liu, Andrew D Dick   +7 more
doaj   +1 more source