Results 21 to 30 of about 110,459 (310)

Mechanism of action of platinum nanoparticles implying from antioxidant to metabolic programming in light-induced retinal degeneration model

Redox Biology, 2023
Photoreceptors (PRs) degeneration is central to visual impairment and loss in most blind retinal diseases, including age-related macular disease (AMD) and diabetic retinopathy (DR).
Lin Su, Xiaoqun Gong, Ruiyan Fan, Tianwen Ni, Fuhua Yang, Xiaomin Zhang, Xiaorong Li   +6 more
doaj   +1 more source

Recent developments of neuroprotective agents for degenerative retinal disorders

Neural Regeneration Research, 2022
Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which are caused by a group of retinal diseases affecting various age groups, and increasingly prevalent in the ...
Kepeng Ou, Youjian Li, Ling Liu, Hua Li, Katherine Cox, Jiahui Wu, Jian Liu, Andrew D Dick   +7 more
doaj   +1 more source

Microglia in Retinal Degeneration [PDF]

Frontiers in Immunology, 2019
The retina is a complex tissue with multiple cell layers that are highly ordered. Its sophisticated structure makes it especially sensitive to external or internal perturbations that exceed the homeostatic range. This necessitates the continuous surveillance of the retina for the detection of noxious stimuli.
Khalid Rashid, Isha Akhtar-Schaefer, Thomas Langmann, Thomas Langmann   +3 more
openaire   +3 more sources

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]

PLoS Genetics, 2005
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John   +6 more
doaj   +2 more sources

Neural Reprogramming in Retinal Degeneration [PDF]

Investigative Opthalmology & Visual Science, 2007
Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration.Excitation mapping with organic ...
Marc, Robert E, Jones, Bryan W, Anderson, James R, Kinard, Krista, Marshak, David W, Wilson, John H, Wensel, Theodore, Lucas, Robert J   +7 more
openaire   +2 more sources

Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration

Cell Reports, 2020
Summary: Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction.
Kelly Mulfaul, Ema Ozaki, Nilisha Fernando, Kiva Brennan, Kathleen R. Chirco, Emma Connolly, Chris Greene, Arvydas Maminishkis, Robert G. Salomon, Mikhail Linetsky, Riccardo Natoli, Robert F. Mullins, Matthew Campbell, Sarah L. Doyle   +13 more
doaj   +1 more source

Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors

Cells
Three-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines to allow in vitro studies on retinal progenitors and photoreceptors and their developmental dynamics
Oleksandr Zabiegalov, Adeline Berger, Dhryata Kamdar, Kabirou Adamou, Chuanxi Tian, Martial Mbefo, Mathieu Quinodoz, Florian Udry, Carlo Rivolta, Corinne Kostic, Yvan Arsenijevic   +10 more
doaj   +1 more source

Genetic and clinical characteristics of PROM1-related retinal degeneration in Korean

Scientific Reports, 2023
This scientific report aims to comprehensively describe the genetic and clinical characteristics of PROM1-related retinal degeneration in Korean patients.
Sungsoon Hwang, Se Woong Kang, Ja-Hyun Jang, Sang Jin Kim   +3 more
doaj   +1 more source

Retinal changes in an ATP-induced model of retinal degeneration

Frontiers in Neuroanatomy, 2016
In rodents and felines, intravitreal administration of adenosine triphosphate (ATP) has been shown to induce photoreceptor death providing a tractable model of retinal degeneration in these species.
Felix Peter Aplin, Kirstan Anne Vessey, Chi D Luu, Robyn H Guymer, Robert K Shepherd, Erica Lucy Fletcher   +5 more
doaj   +1 more source

Coexistence of Peripheral Retinal Diseases with Macular Hole

Türk Oftalmoloji Dergisi, 2019
Objectives:To investigate the frequency of retinal tear, retinal hole, and lattice degeneration in peripheral retinal examination of patients with macular hole.Materials and Methods:The files of patients who underwent pars plana vitrectomy surgery with a
Erdoğan Yaşar, Nazmiye Erol, Mustafa Değer Bilgeç, Ayşe İdil Çakmak   +3 more
doaj   +1 more source