Results 1 to 10 of about 119,076 (326)
Lack of the Sodium-Driven Chloride Bicarbonate Exchanger NCBE Impairs Visual Function in the Mouse Retina [PDF]
, 2012 Regulation of ion and pH homeostasis is essential for normal neuronal function. The sodium-driven chloride bicarbonate exchanger NCBE (Slc4a10), a member of the SLC4 family of bicarbonate transporters, uses the transmembrane gradient of sodium to drive ...
Dedek, Karin +12 more
core +13 more sources
Intrinsically Photosensitive Retinal Ganglion Cells [PDF]
Science China Life Sciences, 2010 A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina. These intrinsically photosensitive retinal ganglion cells (ipRGCs) express a photopigment, melanopsin that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor input.
Pickard, Gary E., Sollars, Patricia J.
openaire +6 more sources
miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage
Cells, 2021 The purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension ...
Ben Mead +3 more
doaj +1 more source
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]
PLoS Genetics, 2005 In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby +6 more
doaj +2 more sources
Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma. [PDF]
PLoS ONE, 2013 Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss.
Pete A Williams +6 more
doaj +1 more source
Protecting retinal ganglion cells [PDF]
Eye, 2017 Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including ...
T Z, Khatib, K R, Martin
openaire +2 more sources
Acta Neuropathologica Communications, 2023 Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai +7 more
doaj +1 more source
Neural Regeneration Research, 2023 [INLINE:1] Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.
Zhe Liu +12 more
doaj +1 more source
Retinal ganglion cells in diabetes [PDF]
The Journal of Physiology, 2008 Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting
Timothy S, Kern, Alistair J, Barber
openaire +2 more sources
Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth
Neural Regeneration Research, 2021 Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or injury. However, the effects and mechanisms of macrophage activation on neuronal survival remain unclear. In the present
Jia-Jian Liang +6 more
doaj +1 more source