Results 1 to 10 of about 103,275 (189)
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]
PLoS Genetics, 2005 In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby +6 more
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miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage
Cells, 2021 The purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension ...
Ben Mead +3 more
doaj +1 more source
On the Generation and Regeneration of Retinal Ganglion Cells [PDF]
Frontiers in Cell and Developmental Biology, 2020 Retinal development follows a conserved neurogenic program in vertebrates to orchestrate the generation of specific cell types from multipotent progenitors in sequential but overlapping waves. In this program, retinal ganglion cells (RGCs) are the first cell type generated.
Viviane M. Oliveira-Valença +4 more
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Intrinsically Photosensitive Retinal Ganglion Cells [PDF]
Science China Life Sciences, 2010 A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina. These intrinsically photosensitive retinal ganglion cells (ipRGCs) express a photopigment, melanopsin that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor input.
Pickard, Gary E., Sollars, Patricia J.
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Protecting retinal ganglion cells [PDF]
Eye, 2017 Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including ...
Keith R Martin, Tasneem Z Khatib
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Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma. [PDF]
PLoS ONE, 2013 Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss.
Pete A Williams +6 more
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Neurogenesis and Specification of Retinal Ganglion Cells [PDF]
International Journal of Molecular Sciences, 2020 Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated during development, followed by the other retinal cell types. How are retinal progenitor cells (RPCs) able to produce these cell types in a specific and timely order?
Nguyen-Ba-Charvet, Kim Tuyen +1 more
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Retinal ganglion cells in diabetes [PDF]
The Journal of Physiology, 2008 Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting
Alistair J. Barber, Timothy S. Kern
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Encoding surprise by retinal ganglion cells
PLOS Computational Biology, 2022 The efficient coding hypothesis posits that early sensory neurons transmit maximal information about sensory stimuli, given internal constraints. A central prediction of this theory is that neurons should preferentially encode stimuli that are most surprising.
Danica Despotović +3 more
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Acta Neuropathologica Communications, 2023 Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai +7 more
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