Results 31 to 40 of about 103,275 (189)
Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma
Neural Regeneration Research, 2021 The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
doaj +1 more source
Advances in retinal ganglion cell imaging [PDF]
Eye, 2015 Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I Balendra +5 more
openaire +3 more sources
Simple RGC: ImageJ plugins for counting retinal ganglion cells and determining the transduction efficiency of viral vectors in retinal wholemounts [PDF]
Journal of Open Research Software, 9(1), 2021, p.15, 2020 Simple RGC consists of a collection of ImageJ plugins to assist researchers investigating retinal ganglion cell (RGC) injury models in addition to helping assess the effectiveness of treatments. The first plugin named RGC Counter accurately calculates the total number of RGCs from retinal wholemount images.
arxiv +1 more source
Assessing retinal ganglion cell damage [PDF]
Eye, 2017 Retinal ganglion cell (RGC) loss is the hallmark of optic neuropathies, including glaucoma, where damage to RGC axons occurs at the level of the optic nerve head. In experimental glaucoma, damage is assessed at the axon level (in the retinal nerve fibre layer and optic nerve head) or at the soma level (in the retina).
Corey A. Smith +2 more
openaire +3 more sources
Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies
Frontiers in Neuroscience, 2018 Sight is a major sense for human and visual impairment profoundly affects quality of life, especially retinal degenerative diseases which are the leading cause of irreversible blindness worldwide.
Oriane Rabesandratana +2 more
doaj +1 more source
Suppressed retinal degeneration in aged wild type and APPswe/PS1ΔE9 mice by bone marrow transplantation. [PDF]
PLoS ONE, 2013 Alzheimer's disease (AD) is an age-related condition characterized by accumulation of neurotoxic amyloid β peptides (Aβ) in brain and retina. Because bone marrow transplantation (BMT) results in decreased cerebral Aβ in experimental AD, we hypothesized ...
Yue Yang +6 more
doaj +1 more source
Do retinal ganglion cells project natural scenes to their principal subspace and whiten them? [PDF]
, 2016 Several theories of early sensory processing suggest that it whitens sensory stimuli. Here, we test three key predictions of the whitening theory using recordings from 152 ganglion cells in salamander retina responding to natural movies. We confirm the previous finding that firing rates of ganglion cells are less correlated compared to natural scenes ...
arxiv +1 more source
Retinal adaptation and invariance to changes in higher-order stimulus statistics [PDF]
PLOS One 9 (2014): e85841, 2012 Adaptation in the retina is thought to optimize the encoding of natural light signals into sequences of spikes sent to the brain. However, adaptation also entails computational costs: adaptive code is intrinsically ambiguous, because output symbols cannot be trivially mapped back to the stimuli without the knowledge of the adaptive state of the ...
arxiv +1 more source
Neuroprotection of Retinal Ganglion Cells [PDF]
, 2010 Therapeutic efforts for treatment of glaucoma have focused on reduction of intraocular pressure as the main objective. In clinical practice, intraocular pressure (IOP) control has been expected to slow or arrest the glaucoma progression. However, clinicians have been confronted with significant glaucoma progression even when achieving control of ...
Peter A. Netland +2 more
openaire +2 more sources
High accuracy decoding of dynamical motion from a large retinal population [PDF]
, 2014 Motion tracking is a challenge the visual system has to solve by reading out the retinal population. Here we recorded a large population of ganglion cells in a dense patch of salamander and guinea pig retinas while displaying a bar moving diffusively.
arxiv +1 more source