Results 41 to 50 of about 197,248 (310)

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis

Neural Regeneration Research, 2015
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore
Yue He, Jie Chen, Shu-guang Zhang, Yuan-sheng Yuan, Yan Li, Hong-bin Lv, Jin-hua Gan   +6 more
doaj   +1 more source

Retinal Processing: Insights from Mathematical Modelling

Journal of Imaging, 2022
The retina is the entrance of the visual system. Although based on common biophysical principles, the dynamics of retinal neurons are quite different from their cortical counterparts, raising interesting problems for modellers.
Bruno Cessac
doaj   +1 more source

Damage and repair in retinal degenerative diseases: Molecular basis through clinical translation

Neural Regeneration Research
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative ...
Ziting Zhang, Junfeng Ma, Wahid Shah, Xin Quan, Tao Ding, Yuan Gao   +5 more
doaj   +1 more source

Spatial distribution of excitatory synapses on the dendrites of ganglion cells in the mouse retina. [PDF]

PLoS ONE, 2014
Excitatory glutamatergic inputs from bipolar cells affect the physiological properties of ganglion cells in the mammalian retina. The spatial distribution of these excitatory synapses on the dendrites of retinal ganglion cells thus may shape their ...
Yin-Peng Chen, Chuan-Chin Chiao
doaj   +1 more source

Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush

Neural Regeneration Research, 2023
The retinal ganglion cells of the optic nerve have a limited capacity for self-repair after injury. Valproate is a histone deacetylase inhibitor and multitarget drug, which has been demonstrated to protect retinal neurons.
Feng Pan, Dan Hu, Li-Juan Sun, Qian Bai, Yu-Sheng Wang, Xu Hou   +5 more
doaj   +1 more source

Single-cell RNA sequencing analysis of the retina under acute high intraocular pressure

Neural Regeneration Research
High intraocular pressure causes retinal ganglion cell injury in primary and secondary glaucoma diseases, yet the molecular landscape characteristics of retinal cells under high intraocular pressure remain unknown. Rat models of acute hypertension ocular
Shaojun Wang, Siti Tong, Xin Jin, Na Li, Pingxiu Dang, Yang Sui, Ying Liu, Dajiang Wang   +7 more
doaj   +1 more source

Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells

Scientific Reports, 2018
Retinal organoids are three-dimensional structures derived from human pluripotent stem cells (hPSCs) which recapitulate the spatial and temporal differentiation of the retina, serving as effective in vitro models of retinal development.
Clarisse M. Fligor, Kirstin B. Langer, Akshayalakshmi Sridhar, Yuan Ren, P. K. Shields, Michael C. Edler, Sarah K. Ohlemacher, Valentin M. Sluch, D. Zack, Chi Zhang, D. Suter, Jason S. Meyer   +11 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

Frontiers in Neurology, 2017
There is increasing awareness on the role played by circadian rhythm abnormalities in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).
C. La Morgia, F. Ross-Cisneros, A. Sadun, V. Carelli   +3 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source