Results 41 to 50 of about 286,988 (401)
Brazilian Journal of Medical and Biological Research, 2005 Exclusion of the transcription factor Max from the nucleus of retinal ganglion cells is an early, caspase-independent event of programmed cell death following damage to the optic axons.
H. Petrs-Silva +4 more
doaj +1 more source
Scientific Reports, 2021 Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva +7 more
doaj +1 more source
Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies
Frontiers in Neuroscience, 2018 Sight is a major sense for human and visual impairment profoundly affects quality of life, especially retinal degenerative diseases which are the leading cause of irreversible blindness worldwide.
Oriane Rabesandratana +2 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 cause glaucoma in ...
Lauren K. Wareham +8 more
doaj +1 more source
Dorsal lateral geniculate substructure in the Long-Evans rat: A cholera toxin B-subunit study [PDF]
Front. Neuroanat. 6:40 (2012), 2012 This study describes the substructure of the dorsal lateral geniculate nucleus of the thalamus of the pigmented rat (Rattus norvegicus) based on the eye-of-origin of its retinal ganglion cell inputs. We made monocular intra-ocular injections of the B-subunit of cholera toxin (CTB), a sensitive anterograde tracer, in three adult male Long-Evans rats. In
arxiv +1 more source
Simple RGC: ImageJ plugins for counting retinal ganglion cells and determining the transduction efficiency of viral vectors in retinal wholemounts [PDF]
Journal of Open Research Software, 9(1), 2021, p.15, 2020 Simple RGC consists of a collection of ImageJ plugins to assist researchers investigating retinal ganglion cell (RGC) injury models in addition to helping assess the effectiveness of treatments. The first plugin named RGC Counter accurately calculates the total number of RGCs from retinal wholemount images.
arxiv +1 more source
Molecular Therapy: Methods & Clinical Development, 2017 Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that ...
Kosuke Fujita +3 more
doaj +1 more source
Functional diversity of human intrinsically photosensitive retinal ganglion cells
Science, 2019 Sensing light without forming images In the rodent retina, intrinsically photosensitive retinal ganglion cells (ipRGCs) entrain circadian rhythms, modulate mood, and signal pupillary accommodation.
L. S. Mure +3 more
semanticscholar +1 more source
Organization of the dorsal lateral geniculate nucleus in the mouse [PDF]
, 2017 The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the principal conduit for visual information from retina to visual cortex. Viewed initially as a simple relay, recent studies in the mouse reveal far greater complexity in the way input from
Guido, William, Kerschensteiner, Daniel
core +2 more sources
Advances in retinal ganglion cell imaging [PDF]
Eye, 2015 Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I Balendra +5 more
openaire +3 more sources