Results 81 to 90 of about 4,628,424 (310)

Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes

Neural Regeneration Research
Diabetic retinopathy is a prominent cause of blindness in adults, with early retinal ganglion cell loss contributing to visual dysfunction or blindness.
Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhong   +8 more
doaj   +1 more source

Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures

Journal of Pharmacological Sciences, 2004
We examined possible involvement of nitric oxide synthase (NOS) on ganglion cell death in explant cultures of neonatal rat retina. Survival of retinal ganglion cells was significantly prolonged by a broad-spectrum NOS inhibitor Nω-nitro-L-arginine ...
Hiroshi Katsuki, Rie Yamamoto, Daisuke Nakata, Toshiaki Kume, Akinori Akaike   +4 more
doaj   +1 more source

Retina‐Inspired Bi‐Based Terahertz Photonic Neuromorphic Devices

Advanced Science, EarlyView.
Combined with effective band alignment and substrate engineering, bismuth materials are introduced to form terahertz photonic bio‐inspired devices with picosecond short‐term plasticity to enable multi‐scene visual perception. Thus obtained hardware through the terahertz optical neural network (THz‐ONN) demonstrates high recognition accuracy, providing ...
Pujing Zhang, Donggang Xie, Longyu Shi, Mengyuan Wang, Huiwen Shi, Yu Wu, Menglei Li, Guangwei She, Peijie Wang, Wensheng Shi, Cunlin Zhang, Kuijuan Jin, Guozhen Yang, Qingli Zhou, Chen Ge   +14 more
wiley   +1 more source

Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition

Journal of Neuroinflammation, 2023
Background Optic nerve injury (ONI) is a key cause of irreversible blindness and triggers retinal ganglion cells (RGCs) change and synapse loss. Microglia is the resistant immune cell in brain and retina and has been demonstrated to be highly related ...
Ke Yao, Qianxue Mou, Xiaotong Lou, Meng Ye, Bowen Zhao, Yuanyuan Hu, Jing Luo, Hong Zhang, Xing Li, Yin Zhao   +9 more
doaj   +1 more source

Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]

, 2012
The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Kerstin N. Euler, Ueffing, Marius, Fröhlich, K.J.H., Stefanie Hauck, Marius Ueffing, Euler, K.N., Fröhlich, Kristina J. H., Kerstin Euler, Claudia Alge-priglinger, Stefanie M. Hauck, Deeg, Cornelia A., Hauck, Stefanie M., Kristina J. H. Fröhlich, Euler, Kerstin N., Cornelia A. Deeg, Christoph Szober, Szober, Christoph M., Hauck, S.M., Ueffing, M., Kristina Fröhlich, Cornelia Deeg, Christoph M. Szober, Szober, C.M., Alge-Priglinger, C.S., Alge-Priglinger, Claudia, Deeg, C.A.   +25 more
core   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Activated retinal glia mediated axon regeneration in experimental glaucoma

Neurobiology of Disease, 2012
Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina.
Barbara Lorber, Alessandra Guidi, James W. Fawcett, Keith R. Martin   +3 more
doaj   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

The regulatory role of mitochondrial quality control and post-translational modification in ganglion cell injury caused by retinal ischemia–reperfusion

European Journal of Medical Research
Retinal ganglion cell injury is an irreversible common pathological process caused by retinal ischemia–reperfusion resulting from various ocular diseases, which can lead to vision loss and blindness.
Yige Zhang, Yulin Guo, Mei Sun, Jing Xu, Mengjiao Zhang, Zhenzhen Gu, Like Xie, Xiaofeng Hao   +7 more
doaj   +1 more source

Cell based therapies for glaucoma

Advances in Clinical Neuroscience & Rehabilitation, 2016
Stem cells could be useful in the treatment of glaucoma by improving aqueous outflow to lower eye pressure, by protecting retinal ganglion cells directly against glaucoma damage or by facilitating optic nerve regeneration.
Craig Pearson, Keith Martin
doaj   +1 more source