VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy. [PDF]
Ann Med, 2022 Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes mellitus, representing a major cause of visual impairment in developed countries.
Arrigo A, Aragona E, Bandello F.
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MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A
Frontiers in Pharmacology, 2020 Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan +10 more
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Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization [PDF]
, 2001 Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, were measured and correlated with the ischemia-induced retinal neovascularization in rats.
Crosson, Craig +5 more
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Journal of Imaging, 2018 The pathological process of neovascularization of the retina plays a critical role in causing vision loss in several diseases, including diabetes, retinal vein occlusion, and sickle cell disease. Retinal neovascularization can lead to vitreous hemorrhage
Van Phuc Nguyen +5 more
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Peripheral retinal neovascularization in a patient with obstructive sleep apnea. [PDF]
Am J Ophthalmol Case Rep, 2022 Purpose: To describe a case of peripheral retinal neovascularization and its possible etiological connection to comorbid obstructive sleep apnea. Observations: In this case report we describe a diabetic patient with obstructive sleep apnea who presented ...
Sajnani R +4 more
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Biology, 2021 Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) and age-related macular degeneration (AMD) patients.
Li Huang +6 more
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Retinal neovascularization in the setting of CALR-mutation positive essential thrombocythemia. [PDF]
SAGE Open Med Case Rep, 2023 Patients with Calreticulin ( CALR ) mutation positive essential thrombocythemia are often thought of as having a “low-risk” of thrombotic complications.
Heydinger SP, Abdulaal MR, Wang AL.
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Sea-fan retinal neovascularization associated with rickettsial retinitis: a case report. [PDF]
BMC OphthalmolBackground Rickettsial disease has been commonly associated with retinitis, retinal vasculitis, and optic nerve involvement, but the development of retinal neovascularization has been very rarely reported.
Abroug N +6 more
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Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling [PDF]
EBioMedicine, 2015 Retinal neovascularization is the most common cause of moderate to severe vision loss in all age groups. Despite the use of anti-VEGFA therapies, this complication continues to cause blindness, suggesting a role for additional molecules in retinal ...
Nikhlesh K. Singh +3 more
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CM082 suppresses hypoxia-induced retinal neovascularization in larval zebrafish. [PDF]
Front PharmacolRetinal neovascularization is a common feature of several ocular neovascular diseases, which are the leading cause of blindness in the world. Current treatments are administered through invasive intravitreal injections, leading to poor patient compliance,
Zhang JL, Fan DG, Yin W, Hu B.
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