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Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization

open access: goldeLife, 2019
Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation.
Wenxin Ma   +6 more
doaj   +3 more sources

IL-17A Enhances Retinal Neovascularization. [PDF]

open access: yesInt J Mol Sci, 2023
Retinal neovascularization occurs in proliferative diabetic retinopathy, neovascular glaucoma, and age-related macular degeneration. This type of retinal pathology normally occurs in the later stages of these ocular diseases and is a prevalent cause of ...
Taylor BE   +7 more
europepmc   +2 more sources

Ferrochelatase regulates retinal neovascularization [PDF]

open access: greenbioRxiv, 2020
Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo.
Sheik Pran Babu Sardar Pasha   +2 more
openalex   +2 more sources

VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy. [PDF]

open access: yesAnn Med, 2022
Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes mellitus, representing a major cause of visual impairment in developed countries.
Arrigo A, Aragona E, Bandello F.
europepmc   +2 more sources

MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A

open access: yesFrontiers in Pharmacology, 2020
Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan   +10 more
doaj   +2 more sources

Therapeutic effect against retinal neovascularization in a mouse model of oxygen-induced retinopathy: bone marrow-derived mesenchymal stem cells versus Conbercept

open access: yesBMC Ophthalmology, 2020
Background To study the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSC) against retinal neovascularization and to compare with anti-vascular endothelial growth factor (VEGF) therapy.
Wei Xu   +3 more
doaj   +2 more sources

Therapeutic Effects of Fenofibrate Nano-Emulsion Eye Drops on Retinal Vascular Leakage and Neovascularization

open access: yesBiology, 2021
Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) and age-related macular degeneration (AMD) patients.
Li Huang   +6 more
doaj   +2 more sources

Sea-fan retinal neovascularization associated with rickettsial retinitis: a case report [PDF]

open access: yesBMC Ophthalmology
Background Rickettsial disease has been commonly associated with retinitis, retinal vasculitis, and optic nerve involvement, but the development of retinal neovascularization has been very rarely reported.
Nesrine Abroug   +6 more
doaj   +2 more sources

In Vivo 3D Imaging of Retinal Neovascularization Using Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Imaging

open access: yesJournal of Imaging, 2018
The pathological process of neovascularization of the retina plays a critical role in causing vision loss in several diseases, including diabetes, retinal vein occlusion, and sickle cell disease. Retinal neovascularization can lead to vitreous hemorrhage
Van Phuc Nguyen   +5 more
doaj   +2 more sources

Retinal neovascularization in the setting of -mutation positive essential thrombocythemia [PDF]

open access: yesSAGE Open Medical Case Reports, 2023
Patients with Calreticulin ( CALR ) mutation positive essential thrombocythemia are often thought of as having a “low-risk” of thrombotic complications.
Stanton P Heydinger   +2 more
doaj   +2 more sources

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