Results 1 to 10 of about 33,727 (99)

IL-17A Enhances Retinal Neovascularization. [PDF]

Int J Mol Sci, 2023
Retinal neovascularization occurs in proliferative diabetic retinopathy, neovascular glaucoma, and age-related macular degeneration. This type of retinal pathology normally occurs in the later stages of these ocular diseases and is a prevalent cause of vision loss.
Taylor BE, Lee CA, Zapadka TE, Zhou AY, Barber KG, Taylor ZRR, Howell SJ, Taylor PR.   +7 more
europepmc   +3 more sources

Ferrochelatase regulates retinal neovascularization [PDF]

The FASEB Journal, 2020
Abstract Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo. But FECH has not been explored in retinal neovascularization, which underlies diseases like proliferative diabetic ...
Sardar Pasha Sheik Pran Babu, Darcy White, Timothy W. Corson   +2 more
openaire   +3 more sources

Targeting Neuroinflammation in Neovascular Retinal Diseases [PDF]

Frontiers in Pharmacology, 2020
Retinal blood vessels provide the necessary energy, nutrients and oxygen in order to support visual function and remove harmful particles from blood, thus acting to protect neuronal cells. The homeostasis of the retinal vessels is important for the maintenance of retinal visual function.
Tianxi Wang, Demetrios I. Tsirukis, Ye Sun   +2 more
openaire   +3 more sources

ADAM9 Is Involved in Pathological Retinal Neovascularization [PDF]

Molecular and Cellular Biology, 2009
Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the ...
Victor, Guaiquil, Steven, Swendeman, Tsunehiko, Yoshida, Sai, Chavala, Peter A, Campochiaro, Carl P, Blobel   +5 more
openaire   +2 more sources

Response of Experimental Retinal Neovascularization to Thiazolidinediones [PDF]

Archives of Ophthalmology, 2001
To determine the effect of thiazolidinediones (TZDs) on experimental retinal neovascularization.The ability of the TZDs troglitazone and rosiglitazone maleate (1-20 micromol/L) to inhibit retinal endothelial cell (REC) proliferation, migration, tube formation, and signaling was determined in response to vascular endothelial growth factor (VEGF).
T, Murata, Y, Hata, T, Ishibashi, S, Kim, W A, Hsueh, R E, Law, D R, Hinton   +6 more
openaire   +2 more sources

Computer-aided quantification of retinal neovascularization [PDF]

Angiogenesis, 2009
Rodent models of retinal angiogenesis play a pivotal role in angiogenesis research. These models are a window to developmental angiogenesis, to pathological retinopathy, and are also in vivo tools for anti-angiogenic drug screening in cancer and ophthalmic research.
Stahl, Andreas, Connor, Kip M., Sapieha, Przemyslaw, Willett, Keirnan L., Krah, Nathan M., Dennison, Roberta J., Chen, Jing, Guerin, Karen I., Smith, Lois E. H.   +8 more
openaire   +3 more sources

Animal models of choroidal and retinal neovascularization [PDF]

Progress in Retinal and Eye Research, 2010
There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is important when evaluating and utilizing these models. Both CNV and RNV are dynamic processes. A break or defect in Bruchs' membrane is necessary for CNV to develop.
Hans E, Grossniklaus, Shin J, Kang, Lennart, Berglin   +2 more
openaire   +2 more sources

MicroRNA signature and function in retinal neovascularization

World Journal of Biological Chemistry, 2014
Ischemic retinopathies are clinically well-defined chronic microvascular complications characterized by gradually progressive alterations in the retinal microvasculature and a compensatory aberrant neovascularization of the eye. The subsequent metabolic deficiencies result in structural and functional alterations in the retina which is highly ...
Saloni, Agrawal, Brahim, Chaqour
openaire   +2 more sources

Calcitriol Is a Potent Inhibitor of Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2007
Vitamin D compounds inhibit the growth of a variety of tumors in preclinical and clinical studies. Among the mechanisms suggested for this inhibition is antiangiogenesis. Retinal angiogenesis is the basis for vision loss in several major blinding diseases.
Daniel M, Albert, Elizabeth A, Scheef, Shoujian, Wang, Farideh, Mehraein, Soesiawati R, Darjatmoko, Christine M, Sorenson, Nader, Sheibani   +6 more
openaire   +2 more sources

Natriuretic Peptides and the Regulation of Retinal Neovascularization [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
Burtenshaw, Denise, Cahill, Paul A.
openaire   +4 more sources