Involvement of bradykinin B2 receptor in pathological vascularization in oxygen-induced retinopathy in mice and rabbit cornea [PDF]
, 2018 The identification of components of the kallikrein-kinin system in the vitreous from patients with microvascular retinal diseases suggests that bradykinin (BK) signaling may contribute to pathogenesis of retinal vascular complications. BK receptor 2 (B2R)
Donnini, Sandra +5 more
core +2 more sources
Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation. [PDF]
, 2019 Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine
Angelopoulos, CM +8 more
core +1 more source
A novel approach for glaucoma classification by wavelet neural networks using graph-based, statisitcal features of qualitatively improved images [PDF]
arXiv, 2022 In this paper, we have proposed a new glaucoma classification approach that employs a wavelet neural network (WNN) on optimally enhanced retinal images features. To avoid tedious and error prone manual analysis of retinal images by ophthalmologists, computer aided diagnosis (CAD) substantially aids in robust diagnosis.
arxiv
A new role for cofilin in retinal neovascularization
Journal of Cell Science, 2016 Pak1 plays an important role in several cellular processes, including cell migration, but its role in pathological angiogenesis is not known. Here, we have determined its role in pathological retinal angiogenesis using an oxygen-induced retinopathy (OIR)
Raj Kumar +3 more
semanticscholar +1 more source
FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice
Cell Reports, 2017 Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration.
Zhongjie Fu +12 more
doaj +1 more source
Evaluation of Transfer Learning for Classification of: (1) Diabetic Retinopathy by Digital Fundus Photography and (2) Diabetic Macular Edema, Choroidal Neovascularization and Drusen by Optical Coherence Tomography [PDF]
arXiv, 2019 Deep learning has been successfully applied to a variety of image classification tasks. There has been keen interest to apply deep learning in the medical domain, particularly specialties that heavily utilize imaging, such as ophthalmology. One issue that may hinder application of deep learning to the medical domain is the vast amount of data necessary
arxiv
Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? [PDF]
, 2014 Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell ...
Chuluyan, Hector Eduardo +3 more
core +1 more source
Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome. [PDF]
, 2018 PurposeTo evaluate the relationship between retinal vascular caliber and AMD in patients with AIDS.MethodsParticipants enrolled in the Longitudinal Study of the Ocular Complications of AIDS had retinal photographs taken at enrollment.
Danis, Ronald P +4 more
core +1 more source
Journal of Diabetes Research, 2015 NADPH oxidase 4 (Nox4) is a major isoform of NADPH oxidase in retinal endothelial cells. Our previous study suggests that upregulation of Nox4 in retinal endothelial cells contributes to retinal vascular leakage in diabetes.
Jingming Li, J. Wang, Sarah X. Zhang
semanticscholar +1 more source
Correlation between retinal function and microstructural foveal changes in intermediate age related macular degeneration [PDF]
, 2017 Purpose: To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD).
Carnevale, Carmela +3 more
core +2 more sources