Results 91 to 100 of about 38,468 (270)

Squalamine improves retinal neovascularization.

Investigative ophthalmology & visual science, 2000
Modalities for inhibiting neovascularization may be one avenue to the development of effective therapies for retinopathy. The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model.OIR was induced in C57BL6 mice by a 5-day exposure to 75% oxygen from postnatal day (P)7 through P12 ...
R D, Higgins, R J, Sanders, Y, Yan, M, Zasloff, J I, Williams   +4 more
openaire   +1 more source

MCP-1 Deficiency Delays Regression of Pathologic Retinal Neovascularization in a Model of Ischemic Retinopathy [PDF]

, 2008
Michael H. Davies, Andrew J. Stempel, Michael R. Powers   +2 more
openalex   +1 more source

LIN28A blocks the EndMT process of high glucose‐induced HRMECs by stabilizing SIRT6 mRNA

Journal of Diabetes Investigation, EarlyView.
LIN28A promotes mRNA stability of SIRT6 to activate the AMPK signaling, thereby inhibiting the EndMT process induced by HG in HRMECs. ABSTRACT Background Diabetic retinopathy (DR) is a microvascular condition resulting from microangiopathy, causing gradual retinal damage and potential blindness.
Xueying Wang, Zixu Huang, Xiaohui Kuang, Yali Nan, Zhiwen Zhang, Zongming Song   +5 more
wiley   +1 more source

The Long-Noncoding RNA TUG1 Regulates Oxygen-Induced Retinal Neovascularization in Mice via MiR-299

, 2022
Yue Wang, Xue Wang, Yuexia Wang, Yuan Ma, Yu Di   +4 more
openalex   +1 more source

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling

Journal of Diabetes Investigation, EarlyView.
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Jiexin Yu, Xingyu Li, Yanli Liu
wiley   +1 more source

The roles of macrophage migration inhibitory factor in retinal diseases

Neural Regeneration Research
Macrophage migration inhibitory factor (MIF), a multifunctional cytokine, is secreted by various cells and participates in inflammatory reactions, including innate and adaptive immunity. There are some evidences that MIF is involved in many vitreoretinal
Hongbing Zhang, Xianjiao Zhang, Hongsong Li, Bing Wang, Pei Chen, Jiamin Meng   +5 more
doaj   +1 more source

Acute retinal necrosis and ocular neovascularization caused by cytomegalovirus following intravitreal dexamethasone implant (Ozurdex^®) in an immunocompetent patient [PDF]

, 2016
Alexander S. Thrane, Morten Hove, Bård Kjersem, Jørgen Krohn   +3 more
openalex   +1 more source

Association between continuous glucose monitoring metrics and diabetic retinopathy and albuminuria among Japanese individuals with type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction This study aimed to clarify the relationship between glucose metrics measured by continuous glucose monitoring (CGM) and diabetic retinopathy (DR) and albuminuria among Japanese individuals with type 1 diabetes mellitus. Materials and Methods The study included 294 individuals with type 1 diabetes (68.7% women) who underwent ...
Yuichiro Kondo, Ryo Kubota, Rika Suda, Yukiko Hasegawa, Junko Oya, Satoshi Takagi, Hiroko Takaike, Junnosuke Miura, Tomoko Nakagami   +8 more
wiley   +1 more source

Reconstruction of deep and perforating corneal defects in dogs—A review (Part I/III): Autogenous ocular tissues, donor tissues, and corneal clarity scoring

Veterinary Ophthalmology, Volume 28, Issue 2, Page 519-531, March 2025.
Abstract Corneal reconstruction is a key part of veterinary ophthalmic practice and numerous reconstructive techniques have been described for use in small animals in the peer‐reviewed veterinary literature written in English. Despite the evidence accrued over the last six decades in over 40 clinical articles and numerous other publications on ocular ...
Rick F. Sanchez, Eric C. Ledbetter, Marta Leiva   +2 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source