Results 91 to 100 of about 371,429 (272)

Obesity Alters the Vascular Morphology and VEGF‐A Signaling in Adipose Tissue

FASEB BioAdvances, EarlyView.
Obesity alters cell geometry and vessel morphology in mice adipose tissue by increasing adipocyte size by 78% and reducing vessel density by 51%, while vessel size and capillary basement membrane thickness remain unchanged. Obesity also affects angiogenesis, which is mediated by vascular endothelial growth factor (VEGF) binding kinetics.
Yunjeong Lee, Keith Lionel Tukei, Yingye Fang, Shobhan Kuila, Xinming Liu, Princess I. Imoukhuede   +5 more
wiley   +1 more source

Foveal neovascularization in a patient with Type 2 diabetes mellitus

Oman Journal of Ophthalmology, 2017
Retinal neovascularization in Diabetes mellitus (DM) is commonly seen at the optic disc and mid-periphery. It is rare at the fovea as the fovea is an avascular zone and there are very few case reports of foveal neovascularization in Type 1 DM.
Anisha Seth, Basudeb Ghosh, Vishaal Bhambhwani, Anika Gupta, Usha K Raina   +4 more
doaj   +1 more source

Netrin‐4 Modulates Corneal Wound Healing by Enhancing Corneal Epithelium and Nerve Regeneration

FASEB BioAdvances, EarlyView.
Netrin‐4, an axon guidance protein, induces corneal wound healing by having a dual action on corneal epithelium and nerves. In vitro, Netrin‐4 enhances epithelium healing and neuronal growth in trigeminal ganglia neurons. In vivo, Netrin‐4 accelerated corneal epithelium regeneration in a model of corneal injury in mice. The effect of Netrin‐4 on nerves
Cissy Xiao, Daniel Lara‐Newman, Qiang Zhou, Mark I. Rosenblatt, Victor H. Guaiquil   +4 more
wiley   +1 more source

Calcitriol Is a Potent Inhibitor of Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2007
Vitamin D compounds inhibit the growth of a variety of tumors in preclinical and clinical studies. Among the mechanisms suggested for this inhibition is antiangiogenesis. Retinal angiogenesis is the basis for vision loss in several major blinding diseases.
Elizabeth A. Scheef, Nader Sheibani, Daniel M. Albert, Shoujian Wang, Christine M. Sorenson, Farideh Mehraein, Soesiawati R. Darjatmoko   +6 more
openaire   +2 more sources

Evaluating the Therapeutic Potential of Superoxide Dismutase in a Rat Model of Wet Age‐Related Macular Degeneration

FASEB BioAdvances, EarlyView.
Oral Superoxide Dismutase Therapy Mitigates Choroidal Neovascularization in a Laser‐Induced Rat Model of Wet Age‐Related Macular Degeneration. Oral Administration of GF103, a Superoxide Dismutase From Bacillus amyloliquefaciens, Reduces Choroidal Neovascularization (CNV) in a Laser‐Induced CNV Rat Model.
Hyun Chul Jeong, Chang Sik Cho, Jeong Hyun Kim, Inik Chang, Jeong Hun Kim   +4 more
wiley   +1 more source

circSIRT2/miR‐542‐3p/VASH1 axis regulates endothelial‐to‐mesenchymal transition (EndMT) in subretinal fibrosis in age‐related macular degeneration models

Aging Cell, Volume 24, Issue 4, April 2025.
circSIRT2 inhibited SRF by binding miR‐542‐3p, which stimulated the VASH1 expression and subsequently suppressed EndMT. The circSIRT2/miR‐542‐3p/VASH1 axis may serve as a promising therapeutic target for SRF in nAMD. Abstract Neovascular age‐related macular degeneration (nAMD), characterized by choroidal neovascularization (CNV), is one of the leading ...
Min Zhang, Jiali Wu, Yimin Wang, Yidong Wu, Xiaoling Wan, Mei Jiang, Qiyu Bo, Jieqiong Chen, Xiaodong Sun   +8 more
wiley   +1 more source

Spectrum of peripheral retinal ischemia in Wyburn-Mason syndrome

American Journal of Ophthalmology Case Reports, 2020
Purpose: We report two cases of Wyburn-Mason syndrome that illustrate the spectrum of peripheral retinal ischemia seen in this condition. Observations: A 12-year-old female presented with a retinal arteriovenous malformation and sclerotic vessels ...
Blake Fortes, MD, James Lin, MD, Supalert Prakhunhungsit, MD, Carlos Mendoza-Santiesteban, MD, Audina M. Berrocal, MD   +4 more
doaj  

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

Proceedings of the National Academy of Sciences of the United States of America, 1995
The majority of severe visual loss in the United States results from complications associated with retinal neovascularization in patients with ischemic ocular diseases such as diabetic retinopathy, retinal vein occlusion, and retinopathy of prematurity ...
L. P. Aiello, E. Pierce, E. D. Foley, H. Takagi, Helen Chen, L. Riddle, N. Ferrara, G. King, L. Smith   +8 more
semanticscholar   +1 more source

Influence of scleral thickness on photodynamic therapy outcomes in central serous chorioretinopathy

Acta Ophthalmologica, Volume 103, Issue 3, Page e165-e175, May 2025.
Abstract Purpose To test the prognostic role of anterior scleral substantia propria (ASSP) thickness in predicting the 3‐month response after half‐dose photodynamic therapy (PDT) in central serous chorioretinopathy (CSCR) and to assess its clinical relevance of ASSP in different CSCR phenotypes.
Paolo Forte, Jennifer Cattaneo, Felice Cardillo Piccolino, Alessandro Arrigo, Paolo Corazza, Donatella Musetti, Raffaella Rosa, Carlo Enrico Traverso, Vincenzo Fontana, Marco Lupidi, Chiara Maria Eandi, Massimo Nicolò   +11 more
wiley   +1 more source

Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis

EBioMedicine, 2016
Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related-macular-degeneration are major causes of blindness.
Yan Gong, Zhuo Shao, Zhongjie Fu, Matthew L. Edin, Ye Sun, Raffael G. Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Samuel B. Burnim, Steven S. Meng, Fred B. Lih, John Paul SanGiovanni, Darryl C. Zeldin, Ann Hellström, Lois E.H. Smith   +14 more
doaj   +1 more source