Results 11 to 20 of about 402,915 (338)
eLife, 2019 Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation.
Wenxin Ma +6 more
doaj +3 more sources
MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A
Frontiers in Pharmacology, 2020 Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan +10 more
doaj +2 more sources
BMC Ophthalmology, 2020 Background To study the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSC) against retinal neovascularization and to compare with anti-vascular endothelial growth factor (VEGF) therapy.
Wei Xu +3 more
doaj +2 more sources
Biology, 2021 Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) and age-related macular degeneration (AMD) patients.
Li Huang +6 more
doaj +2 more sources
Journal of Imaging, 2018 The pathological process of neovascularization of the retina plays a critical role in causing vision loss in several diseases, including diabetes, retinal vein occlusion, and sickle cell disease. Retinal neovascularization can lead to vitreous hemorrhage
Van Phuc Nguyen +5 more
doaj +2 more sources
PLoS ONE, 2017 Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions.
Pilar Villacampa +8 more
doaj +2 more sources
Effects of nuclear factor κB expression on retinal neovascularization and apoptosis in a diabetic retinopathy rat model [PDF]
International Journal of Ophthalmology, 2015 AIM:To investigate the expression and role of nuclear factor κB (NF-κB) in diabetic retinopathy (DR) and its relationship with neovascularization and retinal cell apoptosis.METHODS: A total of 80 male Wistar rats were randomly assigned to control (4, 8 ...
Ning Jiang +3 more
doaj +2 more sources
Ocular Syphilis with Retinal and Disc Neovascularization Treated with Bevacizumab: A Case Report
Case Reports in Ophthalmology, 2023 We report the findings observed in a young woman with ocular syphilis complicated with retinal and disc neovascularization successfully treated with intravitreal bevacizumab.
Lucia Comastri +4 more
doaj +1 more source
VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy
Annals medicus, 2022 Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes mellitus, representing a major cause of visual impairment in developed countries.
A. Arrigo, Emanuela Aragona, F. Bandello
semanticscholar +1 more source
Science Advances, 2022 For patients with proliferative diabetic retinopathy (PDR) who do not respond adequately to pan-retinal laser photocoagulation (PRP) or anti–vascular endothelial growth factor (VEGF) therapies, we hypothesized that vascular cells within neovascular ...
Yaowu Qin +14 more
semanticscholar +1 more source