Results 11 to 20 of about 399,940 (338)
Ferrochelatase regulates retinal neovascularization [PDF]
The FASEB Journal, 2020 AbstractFerrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo. But FECH has not been explored in retinal neovascularization, which underlies diseases like proliferative diabetic retinopathy and retinopathy of prematurity.
Sardar Pasha Sheik Pran Babu +2 more
openaire +5 more sources
MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A
Frontiers in Pharmacology, 2020 Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and age-related macular degeneration (AMD ...
Ji-Tian Guan +10 more
doaj +2 more sources
BMC Ophthalmology, 2020 Background To study the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSC) against retinal neovascularization and to compare with anti-vascular endothelial growth factor (VEGF) therapy.
Wei Xu +3 more
doaj +2 more sources
Biology, 2021 Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) and age-related macular degeneration (AMD) patients.
Li Huang +6 more
doaj +2 more sources
Journal of Imaging, 2018 The pathological process of neovascularization of the retina plays a critical role in causing vision loss in several diseases, including diabetes, retinal vein occlusion, and sickle cell disease. Retinal neovascularization can lead to vitreous hemorrhage
Van Phuc Nguyen +5 more
doaj +2 more sources
A new role for cofilin in retinal neovascularization [PDF]
Journal of Cell Science, 2016 ABSTRACT Pak1 plays an important role in several cellular processes, including cell migration, but its role in pathological angiogenesis is not known. Here, we have determined its role in pathological retinal angiogenesis using an oxygen-induced retinopathy (OIR) model.
Nikhlesh K. Singh +3 more
openaire +4 more sources
Risk of Retinal Neovascularization in Cases of Uveitis [PDF]
Ophthalmology, 2016 To evaluate the risk of and risk factors for retinal neovascularization (NV) in cases of uveitis.Retrospective cohort study.Patients with uveitis at 4 US academic ocular inflammation subspecialty practices.Data were ascertained by standardized chart review. Prevalence data analysis used logistic regression.
Douglas A. Jabs +18 more
openaire +4 more sources
PLoS ONE, 2017 Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions.
Pilar Villacampa +8 more
doaj +2 more sources
eLife, 2019 Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation.
Wenxin Ma +6 more
doaj +2 more sources
VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy. [PDF]
Ann Med, 2022 Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes mellitus, representing a major cause of visual impairment in developed countries.
Arrigo A, Aragona E, Bandello F.
europepmc +2 more sources