Results 21 to 30 of about 402,915 (338)

Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy

Frontiers in Molecular Neuroscience, 2023
Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-time and facilitate angiogenesis during retinal development. In certain retinal diseases, the activated microglia promote retinal angiogenesis in hypoxia stress
Xue-Yan Fu, Shuyu Feng, Huan Qin, Lin Yan, C. Zheng, Kai Yao   +5 more
semanticscholar   +1 more source

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration. [PDF]

Front Pharmacol
Wang X, Liang X, Huang S, Wei M, Xu Y, Chen X, Miao Y, Zong R, Lin X, Li S, Liu Z, Chen Q.   +11 more
europepmc   +3 more sources

Ferulic acid alleviates retinal neovascularization by modulating microglia/macrophage polarization through the ROS/NF-κB axis

Frontiers in Immunology, 2022
Inflammation plays a pivotal role in ischemia-induced retinal neovascularization. Targeting microglia/macrophage-based neuroinflammation presents a promising therapeutic strategy.
Xiaowei Sun, Lusheng Ma, Xiao Li, Jiao Wang, Yuanbin Li, Zijing Huang   +5 more
semanticscholar   +1 more source

Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy

Investigative Ophthalmology and Visual Science, 2022
Purpose Retinal neovascularization is a major cause of blindness. This study aimed to investigate the effects of IL-19 and the underlying mechanisms in a mouse model of oxygen-induced retinopathy (OIR). Methods C57BL/6J wild-type mice and IL-19 knockout (
Jingling Zou, Wei Tan, Bingyan Li, Zicong Wang, Yun Li, J. Zeng, B. Jiang, Shigeo Yoshida, Yedi Zhou   +8 more
semanticscholar   +1 more source

Intravitreal Aflibercept as a Rescue Therapy for Retinal Neovascularization and Macular Edema due to Eales Disease

Case Reports in Ophthalmological Medicine, 2021
We report the rescue effect of intravitreal aflibercept injections on retinal neovascularization and macular edema due to Eales disease. Case 1 was a 36-year-old female. Intravitreal aflibercept was administered as rescue therapy after persistent retinal
Ning-Yi Hsia, Chun-Ju Lin, Chun-Ting Lai, Henry Bair, Cheng-Hsien Chang, Jane-Ming Lin, Yi-Yu Tsai   +6 more
doaj   +1 more source

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.

Journal of Clinical Investigation, 2021
Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease.
Jing Zhang, Yaowu Qin, Mireya Martínez, Miguel Flores-Bellver, Murilo Rodrigues, Aumreetam Dinabandhu, Xuan Cao, M. Deshpande, Yu Qin, Silvia Aparicio-Domingo, Y. Rui, S. Tzeng, Shaima Salman, Jinxia Yuan, A. Scott, J. Green, M. V. Canto-Soler, G. Semenza, S. Montaner, Akrit Sodhi   +19 more
semanticscholar   +1 more source

Peripheral retinal neovascularization in a patient with obstructive sleep apnea

American Journal of Ophthalmology Case Reports, 2022
Purpose: To describe a case of peripheral retinal neovascularization and its possible etiological connection to comorbid obstructive sleep apnea. Observations: In this case report we describe a diabetic patient with obstructive sleep apnea who presented ...
Ravin Sajnani, Elena Karapetian, Abhinav Golla, Irena Tsui, David Sarraf   +4 more
doaj   +1 more source

The progress of prophylactic treatment in retinopathy of prematurity [PDF]

International Journal of Ophthalmology, 2018
Retinopathy of prematurity (ROP) is a retinal vascular disorder frequently found in premature infants. Different therapeutic strategies have been developed to treat ROP.
Hong-Bing Zhang, Xiao-Dong Wang, Kun Xu, Xiao-Gang Li   +3 more
doaj   +1 more source

Nattokinase Attenuates Retinal Neovascularization Via Modulation of Nrf2/HO-1 and Glial Activation

Investigative Ophthalmology and Visual Science, 2021
Purpose Nattokinase (NK), an active ingredient extracted from traditional food Natto, has been studied for prevention and treatment of cardiovascular diseases due to various vasoprotective effects, including fibrinolytic, antihypertensive, anti ...
Zijing Huang, T. Ng, Weiqi Chen, Xiaowei Sun, Ding-guo Huang, D. Zheng, Jingsheng Yi, Yanxuan Xu, Xi Zhuang, Shaolang Chen   +9 more
semanticscholar   +1 more source

An Endostatin-lentivirus (ES-LV)-EPC gene therapy agent for suppression of neovascularization in oxygen-induced retinopathy rat model

BMC Molecular and Cell Biology, 2020
Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun, Ke Yao   +4 more
doaj   +1 more source