IL-17A Enhances Retinal Neovascularization [PDF]
International Journal of Molecular Sciences, 2023 Retinal neovascularization occurs in proliferative diabetic retinopathy, neovascular glaucoma, and age-related macular degeneration. This type of retinal pathology normally occurs in the later stages of these ocular diseases and is a prevalent cause of vision loss.
Brooklyn E. Taylor +7 more
openaire +3 more sources
Vitamin D receptor expression is essential during retinal vascular development and attenuation of neovascularization by 1, 25(OH)2D3. [PDF]
PLoS ONE, 2017 Vitamin D provides a significant benefit to human health, and its deficiency has been linked to a variety of diseases including cancer. Vitamin D exhibits anticancer effects perhaps through inhibition of angiogenesis. We previously showed that the active
Nasim Jamali +4 more
doaj +2 more sources
A pilot optical coherence tomography angiography classification of retinal neovascularization in retinopathy of prematurity [PDF]
Scientific ReportsExtraretinal neovascularization is a hallmark of treatment-requiring retinopathy of prematurity (ROP). Optical coherence tomography angiography (OCTA) offers vascular flow and depth information not available from indirect ophthalmoscopy and structural ...
Xi Chen +10 more
doaj +2 more sources
CM082 suppresses hypoxia-induced retinal neovascularization in larval zebrafish [PDF]
Frontiers in PharmacologyRetinal neovascularization is a common feature of several ocular neovascular diseases, which are the leading cause of blindness in the world. Current treatments are administered through invasive intravitreal injections, leading to poor patient compliance,
Jun-long Zhang +4 more
doaj +2 more sources
Peripapillary retinal neovascularization and vitreous hemorrhage secondary to peripapillary pachychoroid syndrome [PDF]
American Journal of Ophthalmology Case ReportsPurpose: To report a case of peripapillary pachychoroid syndrome (PPS) complicated with peripapillary retinal neovascularization causing vitreous hemorrhage.
Imène Zhioua Braham +4 more
doaj +2 more sources
PLoS ONE, 2017 Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions.
Pilar Villacampa +8 more
doaj +2 more sources
Imatinib Ameliorated Retinal Neovascularization by Suppressing PDGFR-α and PDGFR-β
Cellular Physiology and Biochemistry, 2018 Background/Aims: Platelet-derived growth factors (PDGFs) have emerged as pivotal in pathological angiogenesis, which is a hallmark of various tumors and retinal diseases.
Lingli Zhou +10 more
doaj +2 more sources
Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration [PDF]
Frontiers in PharmacologyPurposeThis study aims to investigate the effects and mechanism of action of metformin on retinal neovascularization and fibrosis in a mouse model of neovascular age-related macular degeneration (nAMD).MethodsVery low-density lipoprotein receptor ...
Xin Wang +14 more
doaj +2 more sources
Risk of Retinal Neovascularization in Cases of Uveitis [PDF]
Ophthalmology, 2016 To evaluate the risk of and risk factors for retinal neovascularization (NV) in cases of uveitis.Retrospective cohort study.Patients with uveitis at 4 US academic ocular inflammation subspecialty practices.Data were ascertained by standardized chart review. Prevalence data analysis used logistic regression.
Douglas A. Jabs +18 more
openaire +4 more sources
A new role for cofilin in retinal neovascularization [PDF]
Journal of Cell Science, 2016 ABSTRACT Pak1 plays an important role in several cellular processes, including cell migration, but its role in pathological angiogenesis is not known. Here, we have determined its role in pathological retinal angiogenesis using an oxygen-induced retinopathy (OIR) model.
Nikhlesh K. Singh +3 more
openaire +4 more sources