Results 21 to 30 of about 371,429 (272)
Journal of Clinical Investigation, 2021 Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease.
Jing Zhang +19 more
semanticscholar +1 more source
Nattokinase Attenuates Retinal Neovascularization Via Modulation of Nrf2/HO-1 and Glial Activation
Investigative Ophthalmology and Visual Science, 2021 Purpose Nattokinase (NK), an active ingredient extracted from traditional food Natto, has been studied for prevention and treatment of cardiovascular diseases due to various vasoprotective effects, including fibrinolytic, antihypertensive, anti ...
Zijing Huang +9 more
semanticscholar +1 more source
Case Reports in Ophthalmological Medicine, 2021 We report the rescue effect of intravitreal aflibercept injections on retinal neovascularization and macular edema due to Eales disease. Case 1 was a 36-year-old female. Intravitreal aflibercept was administered as rescue therapy after persistent retinal
Ning-Yi Hsia +6 more
doaj +1 more source
The progress of prophylactic treatment in retinopathy of prematurity [PDF]
International Journal of Ophthalmology, 2018 Retinopathy of prematurity (ROP) is a retinal vascular disorder frequently found in premature infants. Different therapeutic strategies have been developed to treat ROP.
Hong-Bing Zhang +3 more
doaj +1 more source
BMC Molecular and Cell Biology, 2020 Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai +4 more
doaj +1 more source
CM082 suppresses hypoxia-induced retinal neovascularization in larval zebrafish. [PDF]
Front PharmacolRetinal neovascularization is a common feature of several ocular neovascular diseases, which are the leading cause of blindness in the world. Current treatments are administered through invasive intravitreal injections, leading to poor patient compliance,
Zhang JL, Fan DG, Yin W, Hu B.
europepmc +2 more sources
Genome Biology, 2023 Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear.
Xiaotang Wang +10 more
doaj +1 more source
Scientific Reports, 2023 Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen +5 more
doaj +1 more source
An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Retinal ischemia causes hypoxia-induced neovascularization that stimulates production of proangiogenic cytokines such as VEGF by the hypoxia-inducible transcription factors HIF-1 and HIF-2.
Ayumi Usui‐Ouchi +7 more
semanticscholar +1 more source
Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization. [PDF]
PLoS ONE, 2013 The development and maintenance of retinal vasculature require a precise balance between pro-angiogenic and anti-angiogenic factors. However, mechanisms underlying normal homeostasis of retinal vasculature and pathological changes of disrupted retinal ...
Chun-hong Xia +3 more
doaj +1 more source