Results 171 to 180 of about 34,005 (206)

Transplantation of Retinal Pigment Epithelial Cells

2001
Transplantations of retinal pigment epithelial (RPE) cells into the subretinal space in animal models of age-related macular degeneration (ARMD) have demonstrated that degenerative processes can be prevented, and much hope is pinned on this therapeutic approach. During the past 2 decades, intra- or subretinal transplantation of retinal cells or tissues
Monika Valtink, Judith Weichel, Gisbert Richard, Katrin Engelmann   +3 more
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Functional expression of B7H1 on retinal pigment epithelial cells

Experimental Eye Research, 2008
The interaction of programmed death-1 (PD-1) expressed on T cells with its ligands B7H1 (PDL1) and B7DC (PDL2) is known to be a mechanism of T cell inhibition. In the present study, we examined whether human or murine retinal pigment epithelial (RPE) cells express B7H1 and B7DC, and if so, whether these molecules expressed on RPE cells play an ...
Yoshihiko, Usui, Yoko, Okunuki, Takaaki, Hattori, Takeshi, Kezuka, Hiroshi, Keino, Nobuyuki, Ebihara, Sunao, Sugita, Masahiko, Usui, Hiroshi, Goto, Masaru, Takeuchi   +9 more
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Thrombin is a stimulator of retinal pigment epithelial cell proliferation

Experimental Eye Research, 1991
Two preparations of bovine thrombin were found to stimulate DNA synthesis in cultured human retinal pigment epithelial cells. DNA synthesis was assessed by both [3H]thymidine incorporation into TCA precipitable material and nuclear labeling with [3H]thymidine.
S F, Hackett, J H, Singer, K H, Leschey, P A, Campochiaro   +3 more
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Aldose Reductase in Human Retinal Pigment Epithelial Cells

Experimental Eye Research, 1993
Sugar alcohols have been reported to accumulate in retinal pigment epithelium (RPE) of diabetic animals. This finding has raised interest in the role of RPE in diabetes-associated retinal changes such as cystoid macular edema. To confirm the presence of aldose reductase in this tissue, the NADPH-dependent enzyme was purified to an apparent homogeneity ...
S, Sato, L R, Lin, V N, Reddy, P F, Kador   +3 more
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Retinal Pigment Epithelial Cells Release an Inhibitor of Neovascularization

Archives of Ophthalmology, 1985
Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro.
B M, Glaser, P A, Campochiaro, J L, Davis, M, Sato   +3 more
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Transplantation of Retinal Pigment Epithelial Cells

Archives of Ophthalmology, 1988
A recent article in theNew York Times(Sept 25, 1988, p 13) highlighted findings on the transplantation of retinal pigment epithelial (RPE) cells as a means of "treating" retinal degeneration in the Royal College of Surgeons (RCS) rat. The article stated that this procedure not only was successful in treating retinal degeneration in this animal model ...
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Retinal Pigment Epithelial Cells Release a Chemoattractant for Astrocytes

Archives of Ophthalmology, 1985
Astrocyte migration was studied using a modified Boyden chamber. Astrocytes migrated in response to a concentration gradient (chemotaxis) of retinal pigment epithelial cell-conditioned medium. In contrast, smooth muscle cell- and corneal fibroblast-conditioned media stimulated random migration (chemokinesis) of astrocytes but not chemotaxis ...
S L, Rowen, B M, Glaser
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Repigmentation of human retinal pigment epithelial cells in vitro

Experimental Eye Research, 1985
Cultured human retinal pigment epithelial (RPE) cells readily ingested both melanin and lipofuscin isolated from human RPE cells. Up to 7 days post-challenge ingested granules demonstrated no evidence of lysis or aggregation within secondary lysosomes.
M, Boulton, J, Marshall
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Investigations on Contractile Properties of Retinal Pigment Epithelial Cells

Ophthalmologica, 2010
We have investigated the contractile properties of human and bovine retinal pigment epithelial (RPE) cells in culture. In collagen gels, RPE cells sent out processes which were able to retract the gels. In a glycerinated model of contraction, RPE cells contracted and aggregated into clusters in response to the addition of ATP to the media.
R, Yamakawa, N, Sorgente, S J, Ryan
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Retinal pigment epithelial cell culture

New Cell
Objective: Retinal pigment epithelial cells (RPEs), as the main cellular component of the preretinal membrane, whose excessive proliferation can lead to the development of proliferative vitreoretinopathy as interaction with other cellular components and intercellular substance.
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