Results 161 to 170 of about 138,223 (423)

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

open access: yesCytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah   +2 more
wiley   +1 more source

Bacterial cellulose as a support for the growth of retinal pigment epithelium.

open access: yesBiomacromolecules, 2015
The feasibility of bacterial cellulose (BC) as a novel substrate for retinal pigment epithelium (RPE) culture was evaluated. Thin (41.6 ± 2.2 μm of average thickness) and heat-dried BC substrates were surface-modified via acetylation and polysaccharide ...
S. Gonçalves   +8 more
semanticscholar   +1 more source

Deep Learning-Enhanced Robotic Subretinal Injection with Real-Time Retinal Motion Compensation [PDF]

open access: yesarXiv
Subretinal injection is a critical procedure for delivering therapeutic agents to treat retinal diseases such as age-related macular degeneration (AMD). However, retinal motion caused by physiological factors such as respiration and heartbeat significantly impacts precise needle positioning, increasing the risk of retinal pigment epithelium (RPE ...
arxiv  

Automatic Segmentation of Choroid Layer in EDI OCT Images Using Graph Theory in Neutrosophic Space [PDF]

open access: yesarXiv, 2018
The choroid is vascular tissue located underneath the retina and supplies oxygen to the outer retina; any damage to this tissue can be a precursor to retinal disease. Choroid is almost invisible in Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) images and it is hard for an ophthalmologist to detect this layer manually.
arxiv  

Sustainable Synthesis, Characterization, Cellular Effects of Gold Nanoparticles and Their Applications as Therapeutics in Cancer Therapy

open access: yesChemPlusChem, EarlyView.
Gold nanoparticles (AuNPs) are widely used in biomedicine, electronics, catalysis, and environmental science. Conventional synthesis relies on harsh chemicals, driving interest in eco‐friendly methods using plants, bacteria, fungi, and algae. Biomolecules like polyphenols, proteins, and fatty acids aid nanoparticle synthesis under mild conditions. This
Youfeng Yue   +3 more
wiley   +1 more source

Japanese quail (Coturnix japonica) as the model of human aging retinal processes. Report № 2. Comparative analysis of the composition of retinoids isolated from retinal pigment epithelium of human and Japanese quail eyes

open access: yesОфтальмохирургия, 2013
Purpose. To compare the composition of retinoids of lipofuscin granules (LG) isolated from retinal pigment epithelium (RPE) of human cadaver eyes and Japanese quail. Material and methods. The Japanese quail′s retina and retinal pigment epithelium
M.A. Yakovleva   +6 more
doaj  

Retinal pigment epithelium 65 kDa protein (RPE65): An update

open access: yesProgress in retinal and eye research, 2021
P. Kiser
semanticscholar   +1 more source

Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium

open access: yesJournal of Neuroinflammation, 2015
BackgroundMonocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here,
Matt Rutar   +4 more
semanticscholar   +1 more source

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