Results 71 to 80 of about 138,851 (338)

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Protein Database, Human Retinal Pigment Epithelium [PDF]

Molecular & Cellular Proteomics, 2003
The retinal pigment epithelium (RPE) is a single cell layer adjacent to the rod and cone photoreceptors that plays key roles in retinal physiology and the biochemistry of vision. RPE cells were isolated from normal adult human donor eyes, subcellular fractions were prepared, and proteins were fractionated by electrophoresis.
Karen A, West, Lin, Yan, Karen, Shadrach, Jian, Sun, Azeem, Hasan, Masaru, Miyagi, John S, Crabb, Joe G, Hollyfield, Alan D, Marmorstein, John W, Crabb   +9 more
openaire   +2 more sources

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. [PDF]

PLoS ONE, 2013
In order to facilitate understanding of pigment cell biology, we developed a method to concomitantly purify melanocytes, iridophores, and retinal pigmented epithelium from zebrafish, and analyzed their transcriptomes. Comparing expression data from these
Charles W Higdon, Robi D Mitra, Stephen L Johnson   +2 more
doaj   +1 more source

Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]

, 2018
The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao, Tang, Ronald, Yang, Xian-Jie, Zhang, Xiang-Mei   +3 more
core   +1 more source

Directional optical coherence tomography reveals melanin concentration-dependent scattering properties of retinal pigment epithelium

Journal of Biomedical Optics, 2019
. Optical coherence tomography (OCT) is a powerful tool in ophthalmology that provides in vivo morphology of the retinal layers and their light scattering properties.
R. Meleppat, Pengfei Zhang, M. Ju, Suman K. Manna, Y. Jian, E. Pugh, R. Zawadzki   +6 more
semanticscholar   +1 more source

Photothermal Transport for Guiding Nanoparticles Through the Vitreous Humor

Advanced Science, EarlyView.
Nanosecond laser irradiation of the clinically approved dye indocyanine green (ICG) enables light‐guided nanoparticle transport within the vitreous humor. The combined use of ICG and pulsed laser illumination induces localized convection and thermophoresis, directing particles toward illuminated regions.
Léa Guerassimoff, Yera Ussembayev, Louise De Clerck, Deep Punj, Martijn van den Broek, Filip Beunis, Katrien Remaut, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage   +9 more
wiley   +1 more source

The bisretinoids of retinal pigment epithelium [PDF]

Progress in Retinal and Eye Research, 2012
The retina exhibits an inherent autofluorescence that is imaged ophthalmoscopically as fundus autofluorescence. In clinical settings, fundus autofluorescence examination aids in the diagnosis and follow-up of many retinal disorders. Fundus autofluorescence originates from the complex mixture of bisretinoid fluorophores that are amassed by retinal ...
Janet R, Sparrow, Emily, Gregory-Roberts, Kazunori, Yamamoto, Anna, Blonska, Shanti Kaligotla, Ghosh, Keiko, Ueda, Jilin, Zhou   +6 more
openaire   +2 more sources

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

JAPANESE QUAIL (COTURNIX JAPONICA) AS A MODEL OF ACCELERATED AGING OF HUMAN RETINAL PROCESSES. REPORT 1. ASSESSMENT OF THE AGE RPE LIPOFUSCIN ACCUMULATION DEPENDING ON THE RETINAL AMOUNT OF OXYCAROTENOIDS

Офтальмохирургия, 2015
Purpose. Using the eyes of quails C. japonic as a model system to evaluate age-related accumulation of lipofuscin granules in the cells of the retinal pigment epithelium depending on the level of oxycarotenoids content in the retina and in the retinal ...
P. P. Zak, A. V. Zykova, N. N. Trofimova, M. A. Ostrovsky   +3 more
doaj