Results 61 to 70 of about 33,802 (359)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?

open access: yesJournal of Ophthalmology, 2015
Zeaxanthin and lutein are two carotenoid pigments that concentrated in the retina, especially in the macula. The effects of lutein and zeaxanthin on the prevention and treatment of various eye diseases, including age-related macular degeneration ...
Chunyan Xue   +3 more
doaj   +1 more source

Antifouling All‐Polymeric Microneedle Array for Long‐Term Wearable ECG Monitoring

open access: yesAdvanced Science, EarlyView.
A biocompatible, all‐polymeric MNEs designed for long‐term ECG monitoring is developed. Coated with PEDOT:Tos and zwitterionic SBMA, the MNEs offer ultra‐low impedance and antifouling properties. After 14 days of continuous use, the MNEs accurately detected PQRST complexes, highlighting its potential for long‐term, real‐time ECG monitoring in everyday ...
Ju Hyeon Kim   +4 more
wiley   +1 more source

Investigation of Ocular Alterations in Patients with Alopecia Areata and Its Correlation with the Severity of Disease

open access: yesپزشکی بالینی ابن سینا, 2014
Introduction & Objective: Alopecia areata is the most common skin disease that presents as areas without hair and may affect any hair bearing area of body. Different reports about ocular alterations in patients with alopecia areata are presented. The aim
Ameneh Yazdanfar   +5 more
doaj  

In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope

open access: yesThe Journal of Clinical Investigation, 2022
Background Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases.
Jakub Boguslawski   +15 more
doaj   +1 more source

The science of color and color vision [PDF]

open access: yes, 2021
A survey of color science and color ...
Byrne, Alex, Hilbert, David R.
core  

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

open access: yesAdvanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang   +8 more
wiley   +1 more source

Autofluorescence Imaging for Diagnosis and Follow-up of Cystoid Macular Edema

open access: yesJournal of Ophthalmic & Vision Research, 2012
Lipofuscin results from digestion of photoreceptor outer segments by the retinal pigment epithelium (RPE) and is the principal compound that causes RPE fluorescence during autofluorescence imaging.
Nazanin Ebrahimiadib   +1 more
doaj  

Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering

open access: yesFrontiers in Chemistry, 2022
The first member and eponym of the rhodopsin family was identified in the 1930s as the visual pigment of the rod photoreceptor cell in the animal retina.
Willem J. de Grip   +2 more
doaj   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

open access: yesAdvanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li   +11 more
wiley   +1 more source

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