Results 121 to 130 of about 24,696 (239)
mTORC1 accelerates retinal development via the immunoproteasome
Nature Communications, 2018 One of the determinants of the neuronal subtype produced from retinal progenitor cells is their proliferative potential. Here the authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina ...
Ji-Heon Choi +11 more
doaj +1 more source
Differentiation of Mesenchymal Stem Cells into Retinal Progenitor Cells [PDF]
Ophthalmic Research, 2014 Gustavo Sevlever +2 more
openaire +2 more sources
Techniques for subretinal injections in animals
Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
Characterisation of immortalised human foetal retinal progenitor cell lines [PDF]
, 2008 Inherited retinal dystrophies and age-related macular degeneration (AMD) are leading causes of blindness. Current treatments only slow disease progression in a minority of patients, therefore it is important to develop new treatments that can regenerate ...
Hasan, S.M.
core
Glia, Volume 74, Issue 7, July 2026.Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat +3 more
wiley +1 more source
Mechanisms of Pericyte‐Mediated Cancer Metastasis
Advanced Science, Volume 13, Issue 33, 15 June 2026.Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley +1 more source
Protection & regeneration of [beta]-cells: studies using the nod mouse
, 2009 PhDDiabetes is a chronic disease affecting approximately 250 million people. To date, transplantation-based therapy is the therapy of choice; however, its success is hampered by the scarcity of transplantable human material.
Khoo, Cheen Peen
core
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, Volume 13, Issue 33, 15 June 2026.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
CellsThree-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines to allow in vitro studies on retinal progenitors and photoreceptors and their developmental dynamics
Oleksandr Zabiegalov +10 more
doaj +1 more source